The effects of benzodiazepines on human opioid receptor binding and function

Anesthesia and Analgesia

Volumn 93, Issue 2, 2001, Pages 354-358

  Cox, Richard F ^a   Collins, Mark A ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 HYDROXYBENZYL] N,N DIETHYLBENZAMIDE; BENZODIAZEPINE DERIVATIVE; CHLORDIAZEPOXIDE; DELTA OPIATE RECEPTOR; DIAZEPAM; DIPRENORPHINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; FLUMAZENIL; GI 103996A; GR 89696A; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GW 357476B; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR ANTAGONIST; MIDAZOLAM; MU OPIATE RECEPTOR; NALOXONE; NORBINALTORPHIMINE; OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; HUMAN; NONHUMAN; PRIORITY JOURNAL;

EID: 0034926010     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/00000539-200108000-00024     Document Type: Article

References (17)

1. Intrathecal midazolam in the rat: Evidence for spinally mediated analgesia
2. Differential effects of intrathecal midazolam on morphine-induced antinociception in the rat: Role of spinal opioid receptors
3. Effects of an intrathecally administered benzodiazepine receptor agonist, antagonist and inverse agonist on morphine-induced inhibition of a spinal nociceptive reflex
4. The post-operative analgesic action of midazolam following epidural administration
5. Midazolam for caudal analgesia in children: Comparison with caudal bupivacaine
6. Continuous epidural administration of midazolam and bupivacaine for postoperative analgesia
7. The effect of intrathecal midazolam on post-operative pain
8. The effects of intrathecal midazolam on sympathetic nervous system reflexes in man: A pilot study
9. Intrathecal midazolam for the treatment of chronic mechanical low back pain: A controlled comparison with epidural steroid in a pilot study
10. Actions of midazolam on GABAergic transmission in substantia gelatinosa neurons of adult rat spinal cord slices
11. Sodium ions modulate differentially the effect of a benzodiazepine agonist on rat spinal μ-, δ-, and κ-opioid receptors
12. Delta opioid modulation of the binding of guanosine-5′-O-(3-[35S]thio)triphosphate to NG108-15 cell membranes: Characterization of agonist and inverse agonist effects
13. Acute and chronic effects of opioids on δ and μ receptor activation of G proteins in NG108-15 and SK-N-SH cell membranes
14. 35S]GTPγS binding to membranes: Determination of potencies and efficacies of ligands
15. The spinal potentiating effects and the supraspinal inhibitory effect of midazolam on opioid-induced analgesia in rats
16. Antinociception by intrathecal midazolam involves endogenous neurotransmitters acting at spinal delta opioid receptors
17. Synthesis, biological evaluation, and quantitative receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodizepines as novel tifluadom-like ligands with high affinity and selectivity for κ-opioid receptors