Regulation of MUC1 expression in human mammary cell lines by the c-ErbB2 and Ras signaling pathways

DNA and Cell Biology

Volumn 20, Issue 5, 2001, Pages 265-274

  Scibetta, A G ^a,b   Albanese, I ^b   Morris, J ^a   Cooper, L ^a   Downward, J ^c   Rowe, P P ^d   Taylor Papadimitriou, J ^a  

^a GUY S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF PALERMO   (Italy)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIS ACTING ELEMENT; MESSENGER RNA; MUCIN; PHOSPHATIDYLINOSITOL 3 KINASE; RAF PROTEIN; RAS PROTEIN; WORTMANNIN;

ARTICLE; BREAST CELL; BREAST EPITHELIUM; CANCER CELL; CELL LEVEL; CONTROLLED STUDY; DNA VECTOR; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; ONCOGENE C ERB; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SIGNAL TRANSDUCTION;

EID: 0034922833     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/104454901750232463     Document Type: Article

References (50)

1. The transforming potential of the c-erbB-2 protein is regulated by its autophosphorylation at the carboxyl-terminal domain
2. Integrin-matrix interactions affect the form of the structures developing from human mammary epithelial cells in collagen or fibrin gels
3. Adhesion molecules in breast cancer: Role of α2β1 integrin
4. Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor
5. Morphogenetic and proliferative responses to heregulin of mammary epithelial cells in vitro are dependent on HER2 and HER3 and differ from the response to HER2 homodimerisation or hepatocyte growth factor
6. Activation of the alpha2beta1 integrin prevents c-erbB2-induced scattering and apoptosis of human mammary epithelial cells in collagen
7. Overexpression of the c-erbB-2 oncoprotein: Why does this occur more frequently in ductal carcinoma in situ than in invasive mammary carcinoma and is this of prognostic significance?
8. Efficient immortalization of luminal epithelial cells from human mammary gland by introduction of simian virus 40 large tumor antigen with a recombinant retrovirus
9. Morphological differentiation of hybrids of human mammary epithelial cell lines is dominant and correlates with the pattern of expression of intermediate filaments
10. Branching morphogenesis of human mammary epithelial cells in collagen gels
11. Integrin expression in relation to cell phenotype and malignant change in the human breast
12. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
13. Increasing complexity of Ras signaling
14. Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis
15. Genomic sequencing
16. Aberrant function of the Ras signal transduction pathway in human breast cancer
17. The neu-protein and breast cancer
18. Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin gene
19. Collagen induced morphogenesis and expression of the alpha 2-integrin subunit is inhibited in c-erbB2-transfected human mammary epithelial cells
20. Plasmid vectors with multiple cloning sites and CAT-reporter gene for promoter cloning and analysis in animal cells
21. Regulation of episialin/MUC1 expression in breast carcinoma: A complex interplay between stimulator and inhibitor factor
22. A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII 110 component of the Drosophila TFIID complex and mediates transcriptional activation
23. A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas
24. A new technique for the assay of infectivity of human adenovirus 5 DNA
25. P-regulation of MUC1 in mammary tumors generated in a double-transgenic mouse expressing human MUC1 cDNA under the control of 1.4-kb 5 MUC1 promoter sequence and the middle T oncogene expressed from the MMTV promoter
26. Overexpression of the c-erbB-2 protein in human breast tumor cell lines
27. Oncoprotein networks
28. Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS
29. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
30. Analysis of the tissue-specific promoter of the MUC1 gene
31. Two GC boxes (Sp1 sites) are involved in regulation of the activity of the epithelium-specific MUC1 promoter
32. bcl-2 overexpression inhibits cell death and promotes the morphogenesis, but not tumorigenesis, of human mammary epithelial cells
33. Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain
34. The Sp1 transcription factor regulates cell type specific transcription of MUC1
35. Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions
36. Activation of an inducible c-FosER fusion protein causes-loss of epithelial polarity and triggers pithelial-fibroblastoid cell conversion
37. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
38. Incidence of activating ras oncogene mutations associated with primary and metastatic human breast cancer
39. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1
40. H-ras gene amplification or mutation is not common in human primary breast cancer
41. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
42. A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells
43. Vimentin rather than keratin expression in some hormone-independent breast cancer cell lines and in oncogene-transformed mammary epithelial cells
44. MUC1 and cancer
45. Molecular aspects of mucins
46. Keratin expression in human mammary epithelial cells cultured from normal and malignant tissue: Relation to in vivo phenotypes and influence of medium
47. Increasing complexity of the Ras signaling pathway
48. Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor
49. Sp1 binding plays a critical role in Erb-B2- and v-ras-mediated downregulation of alpha2-integrin expression in human mammary epithelial cells
50. Monoclonal antibodies to epithelial sialomucins recognize epitopes at different cellular sites in adenolymphomas of the parotid gland