Tachykinin-induced bronchoconstriction in sheep is NK-1 receptor mediated and exhibits tachyphylaxis

Respirology

Volumn 6, Issue 2, 2001, Pages 113-123

  Rice, Anthony J ^a,d   Reynolds, Paul N ^b   Reynolds, Ann M ^c   Holmes, Mark D ^c   Scicchitano, Raffaele ^c  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b University of Alabama at Birmingham   (United States)

^c ROYAL ADELAIDE HOSPITAL   (Australia)

^d AUSTRALIAN INSTITUTE OF SPORT   (Australia)

Author keywords

Lung resistance; Sheep; Substance P; Tachykinins; Tachyphylaxis

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; ATROPINE; CROMOGLYCATE DISODIUM; INDOMETACIN; MEPYRAMINE; NEUROKININ 1 RECEPTOR; NEUROKININ A; PHOSPHORAMIDON; SUBSTANCE P; TACHYKININ; TACHYKININ RECEPTOR ANTAGONIST;

ANIMAL MODEL; ARTICLE; BRONCHOSPASM; CONTROLLED STUDY; LUNG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; SHEEP; TACHYPHYLAXIS;

AIRWAY RESISTANCE; ANIMALS; ATROPINE; BLOOD PRESSURE; BRONCHOCONSTRICTION; BRONCHODILATOR AGENTS; HISTAMINE H1 ANTAGONISTS; INJECTIONS, INTRAVENOUS; LUNG; RECEPTORS, NEUROKININ-1; REPRODUCIBILITY OF RESULTS; SHEEP; SUBSTANCE P; TACHYPHYLAXIS;

EID: 0034922143     PISSN: 13237799     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1843.2001.00315.x     Document Type: Article

References (37)

1. Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man
2. Tachykinins, sensory nerves, and asthma: An overview
3. Neutral endopeptidase modulates neurogenic inflammation
4. A role for capsaicin sensitive, tachykinin containing nerves in chronic coughing and sneezing but not in asthma: A hypothesis
5. Tachykinin NK2 receptors predominantly mediate tachykinin-induced contractions in ovine trachea
6. Tachykinins contribute to the acute airways response to allergen in sheep actively sensitized to Ascaris suum
7. Physical properties of human lungs measured during spontaneous respiration
8. Studies of respiratory physiology in the newborn infant. III. Measurements of mechanics of respiration
9. Airway effects of inhaled bradykinin, substance P, and neurokinin A in sheep
10. Inhibition of tachykinin-induced hypotension in dogs by CP-96,345, a selective blocker of NK-1 receptors
11. The effect of tachykinins on sheep bronchomotor tone
12. Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation
13. Rapid desensitization of substance P- but not carbachol-induced increases in inositol trisphosphate and intracellular Ca++ in rat parotid acinar cells
14. Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors
15. Desensitization of the neurokinin 1 receptor is mediated by the receptor carboxy-terminal region, but is not caused by receptor internalization
16. Effect of substance P on cardiovascular and respiratory function in subjects
17. Comparison of neurokinin A and substance P on cardiovascular and airway function in man
18. Neutral endopeptidase activity and airway hyperresponsiveness to neurokinin A in asthmatic subjects in vivo
19. Modulation of neurogenic inflammation by neutral endopeptidase
20. Enhanced expression of neutral endopeptidase (NED in airway epithelium in biopsies from steroid- versus nonsteroid-treated patients with atopic asthma
21. Tachykinin receptor antagonists inhibit hyperpnea-induced bronchocon-striction in guinea pigs
22. Cardiovascular effects of CP-96,345, a non-peptide blocker of tachykinin NK1 receptors
23. Bronchial blood flow affects recovery from constriction in dog lung periphery
24. Facilitatory effects of selective agonists for tachykinin receptors on cholinergic neurotransmission: Evidence for species differences
25. Effect of vagotomy and vagal cooling on bronchoconstrictor response to substance P in sheep
26. Influence of antihistamine (astemizole) and anticholinergic drugs (ipratropium bromide) on bronchoconstriction induced by substance P
27. Substance P-induced airway hyperreactivity is mediated by neuronal M(2) receptor dysfunction
28. Activation of human neutrophils by tachykinins: Effect on formyl-methionyl-leucyl-phenylalanine- and platelet-activating factor-stimulated superoxide anion production and antibody-dependent cell-mediated cytotoxicity
29. Substance P (NK1) receptor immunoreactivity on endothelial cells of the rat tracheal mucosa
30. Induction of normal human eosinophil migration in vitro by substance P
31. In vivo immunomodulation by the neuropeptide substance P
32. Substance P induces histamine release from human pulmonary mast cells
33. Substance P-induced histamine release in tracheally perfused guinea pig lungs
34. Activation of an epithelial neurokinin NK-1 receptor induces relaxation of rat trachea through release of prostaglandin E2
35. Protection of nedocromil sodium on bronchoconstriction induced by inhaled neurokinin A (NKA) in asthmatic patients
36. Effects of nedocromil sodium on airway neurogenic mechanisms
37. Inhaled cromoglycate reduces airway neurogenic inflammation via tachykinin antagonism