Tachykinins contribute to the acute airways response to allergen in sheep actively sensitized to Ascaris suum

Respirology

Volumn 2, Issue 3, 1997, Pages 193-200

  Reynolds, Paul N ^a   Rice, Anthony J ^a   Reynolds, Ann M ^a   Thornton, Andrew T ^a   Holmes, Mark D ^a   Scicchitano, Raffaele ^a  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

Airways; Allergen; Sheep; Tachykinins

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; ALLERGEN; CAPSAICIN; MEMBRANE METALLOENDOPEPTIDASE; NEUROKININ 1 RECEPTOR ANTAGONIST; PHOSPHORAMIDON; TACHYKININ;

AIRWAY RESISTANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASCARIS SUUM; ASTHMA; BRONCHOSPASM; CONTROLLED STUDY; FEMALE; LUNG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION; SHEEP;

EID: 0030725074     PISSN: 13237799     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1843.1997.tb00078.x     Document Type: Article

References (22)

1. Karlsson JA, Sant' Ambrogio G, Widdicombe J. Afferent neural pathways in cough and reflex bronchoconstriction. J. Appl. Physiol 1988; 65: 1007-23.
2. Lundberg JM, Hokfelt T, Martling CR, Saria A, Cuello C. Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man. Cell Tissue Res. 1984; 235: 251-61.
3. Lundberg JM. Tachykinins, sensory nerves, and asthma - an overview. Can. J. Physiol. Pharmacol. 1995; 73: 908-14.
4. Nadel JA. Regulation of neurogenic inflammation by neutral endopeptidase. Am. Rev. Respir. Dis. 1992; 145: S48-S52.
5. Karlsson JA. A role for capsaicin sensitive, tachykinin containing nerves in chronic coughing and sneezing but not in asthma: a hypothesis. Thorax 1993; 48: 396-400.
6. Cannon DC, Ulitzky I, Inkpen JA. Proteins. In: Henry RJ, Cannon DC, Winkleman JW, (eds) Clinical Chemistry Principles and Techniques, 2nd edn. Bioscience Laboratories, Harper and Row, New York, 1974; Chap. 16.
7. Abraham WM, Oliver W Jr, King MM, Yerger L, Wanner A. Effect of pharmacologic agents on antigen-induced decreases in specific lung conductance in sheep. Am. Rev. Respir. Dis. 1981; 124: 554-8.
8. Kleeberger SR, Wagner EM, Adams GK 3rd, Dannenberg AM Jr, Spannhake EW. Effect of repeated antigen exposure on antigen and mediator induced bronchospasm in sheep. J. Appl. Physiol. 1985; 59: 1866-73.
9. Mead J, Whittenberger, JL. Physical properties of human lungs measured during spontaneus respiration. J. Appl. Physiol. 1953; 5: 779-96.
10. Cook CD, Sutherland JM, Segal S et al. Studies of respiratory physiology in the newborn infant. III. Measurements of mechanics of respiration. J. Clin. Invest. 1957; 36: 440-8.
11. Constantine JW, Lebel WS, Woody HA. Inhibition of tachykinin induced hypotension in dogs by CP-96,345, a selective blocker of NK-1 receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 1991; 344: 471-7.
12. Rice A, Holmes M, Thornton A, Reynolds P, Scicchitano R. The effect of infused substance P in normal sheep. Am. J. Respir. Crit. Care Med. 1995; 151: A107 (abstract).
13. Abraham WM, Ahmed A, Cortes A, Delahunt JC. C-fibre desensitisation prevents hyperresponsiveness to cholinergic and antigenic stimuli after antigen challenge in allergic sheep. Am. Rev. Respir. Dis. 1993; 147: A478 (abstract).
14. Alving K, Matran R, Fornhem C, Lundberg JM. Late phase bronchial and vascular responses to allergen in actively-sensitised pigs. Acta Physiol. Scand. 1991; 143: 137-8.
15. Kawano O, Kohrogi H, Yamaguchi T, Araki S, Ando M. Neutral endopeptidase inhibitor potentiates allergic bronchoconstriction in guinea pigs in vivo. J. Appl. Physiol. 1993; 75: 185-90.
16. Nieber K, Baumgarten CR, Rathsack R, Furkert J, Oehme P, Kunkel G. Substance P and β endorphin-Like immunoreactivity in lavage fluids in subjects with and without allergic asthma. J. Allergy Clin. Immunol. 1992; 90: 646-52.
17. Cheung D, Timmers MC, Zwinderman AH, den Hartigh J, Dijkman JH, Sterk PJ. Neutral endopeptidase activity and airway hyperresponsiveness to neurokinin A in asthmatic subjects in vivo. Am. Rev. Respir. Dis. 1993; 148: 1467-73.
18. Abraham WM, Ahmed A, Cortes A et al. Airway effects of inhaled bradykinin, substance P, and neurokinin A in sheep. J. Allergy Clin. Immunol. 1991; 87: 557-64.
19. Crimi N, Polosa R, Pulvirenti G et al. Effect of an inhaled neutral endopeptidase inhibitor, phosphoramidon, on baseline airway calibre and bronchial responsiveness to bradykinin in asthma. Thorax 1995; 50: 505-10.
20. Solway J, Kao BM, Jordan JE et al. Tachykinin receptor antagonists inhibit hypernoea-induced bronchoconstriction in guinea pigs. J. Clin. Invest. 1993; 92: 315-23.
21. Corcoran BM, Haigh AL. The effect of tachykinins on sheep bronchomotor tone. Exp. Physiol. 1992; 77:471-9.
22. Crimi N, Palermo F, Oliveri R et al. Influence of antihistamine (astemizole) and anticholinergic drugs (ipratropium bromide) on bronchoconstriction induced by substance P. Ann. Allergy 1990; 65: 115-20.