Immune consequences of intraocular administration of modified adenoviral vectors

Human Gene Therapy

Volumn 12, Issue 7, 2001, Pages 833-838

  Suber, M L ^a   Hurwitz, M Y ^a   Chevez Barrios P ^a   Hurwitz, R L ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; BETA GALACTOSIDASE; VIRUS VECTOR;

ADENOVIRUS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ESCHERICHIA COLI; EXTERNAL EAR; EYE INFLAMMATION; HYPERSENSITIVITY; IMMUNE RESPONSE; INFLAMMATORY CELL; INOCULATION; MOUSE; NONHUMAN; RETINA DEGENERATION;

ADENOVIRIDAE; ANIMALS; DNA, VIRAL; EAR; EYE; GENE THERAPY; GENETIC VECTORS; HYPERSENSITIVITY, DELAYED; INFLAMMATION; INJECTIONS; INJECTIONS, SUBCUTANEOUS; LAC OPERON; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RETINAL DEGENERATION;

EID: 0034922022     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303401750148801     Document Type: Article

References (21)

1. The use of DNA viruses as vectors for gene therapy
2. Human gene therapy
3. Photoreceptor cell rescue in retinal degeneration (rd) mice by in vitro gene therapy
4. Retinal degeneration in the rd mouse is caused by a defect in the β subunit of rod cGMP-phosphodiesterase
5. Muller and RPE cell response to photoreceptor cell degeneration in aging Fischer rats
6. Cell mediated immune response and stability of intraocular transgene expression after adenovirus-mediated delivery
7. Suicide gene therapy for treatment of retinoblastoma in a murine model
8. Immune privilege extended to allogeneic tumor cells in the vitreous cavity
9. Sub-retinal space and vitreous cavity as immunologically privileged sites for retinal allografts
10. Imposing deviant immunity on the presensitized state
11. Genetic targeting of adenoviral vectors
12. Deviant immune responses to allogeneic tumors injected intracamerally and subcutaneously in mice
13. A brief review of retinitis pigmentosa and the identified retinitis pigmentosa genes
14. Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase β-subunit gene of the rd mouse
15. Immune regulation and the eye: A dangerous compromise
16. Ocular immune privilege and the Faustian dilemma
17. Systemic immune unresponsiveness induced in adult mice by anterior chamber presentation of minor histocompatibility antigens
18. Loss of anterior chamber-associated immune deviation (ACAID) in aged retinal degeneration (rd) mice
19. Analysis of immune deviation elicited by antigens injected into the subretinal space
20. Adenoviruses as gene-delivery vehicles
21. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy