Construction of SIV/HIV-1 chimeric viruses having the IL-5 gene and determination of their ability to replicate and produce IL-5

Archives of Virology

Volumn 146, Issue 6, 2001, Pages 1051-1062

  Kozyrev, I L ^a   Miura, T ^a   Haga, T ^a   Kuwata, T ^a   Hayami, M ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL LINE; CHIMERIC GENE; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE SYSTEM; INTERLEUKIN 5; MONONUCLEAR CELL; PATHOGENICITY; T LYMPHOCYTE; TRANSPOSABLE ELEMENT; VIRUS GENE; VIRUS INFECTION; VIRUS REPLICATION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANIMALS; BASE SEQUENCE; CELL LINE; CELLS, CULTURED; CHIMERA; DNA PRIMERS; GENES, NEF; GENES, VPR; HIV-1; HUMANS; INTERLEUKIN-5; MACACA MULATTA; SIMIAN IMMUNODEFICIENCY VIRUS; TH1 CELLS; TH2 CELLS; VIRULENCE; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SIMIAE; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0034921595     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007050170105     Document Type: Article

References (26)

1. Determinants of HIV-1 coreceptor function on CC chemokine receptor 3
2. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T-helper cells (Th1s) and Th2s
3. Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1α
4. Human immunodeficiency virus infection of monocytic and T-lymphocytic cells: Receptor modulation and differentiation induced by phorbol ester
5. A Th1-Th2 switch is a critical step in the etiology of HIV infection
6. Relationship between interleukin-5 production and variations in eosinophil count during HIV infection in West Africa: Influence of Mycobacterium tuberculosis infection
7. HIV-1: Fifteen proteins and an RNA
8. Construction and characterization of replication-competent simian immunodeficiency virus vectors that express gamma interferon
9. Construction, replication, and immunogenic properties of a simian immunodeficiency virus expressing interleukin-2
10. Construction of an SIV/HIV type 1 chimeric virus with the human interleukin 6 gene and its production of interleukin 6 in monkey and human cells
11. A new approach to AIDS research and prevention: The use of gene-mutated HIV1/SIV chimeric viruses for anti-HIV1 live-attenuated vaccines
12. Deficiency of IL-5 receptor alpha-chain selectively influences the development of the common mucosal immune system independent IgA-producing B-1 cell in mucosa-associated tissues
13. Interleukin-2 and human immunodeficiency virus infection: Pathogenic mechanisms and potential for immunologic enhancement
14. Demonstration of the Th1 to Th2 cytokine shift during the course of HIV-1 infection using cytoplasmic cytokine detection on single cell level by flow cytometry
15. Construction of human immunodeficiency virus1/simian immunodeficiency virus strain mac chimeric viruses having vpr and/or nef of different parental origins and their in vitro and in vivo replication
16. Role of T cell activation and expression of T4 antigen
17. Evidence for type 2 cytokine production and lymphocyte activation in the early phases of HIV-1 infection
18. Molecular cloning and expression of the human interleukin 5 receptor
19. JAK2 and JAK1 constitutively associate with an Interleukin-5 (IL-5) receptor α and βc subunit, respectively, and are activated upon IL-5 stimulation
20. Interleukin-5, eosinophils, and disease
21. Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes
22. Protection of macaques against a SHIV with a homologous HIV-1 env and a pathogenic SHIV-89.6P with a heterologous env by vaccination with multiple gene-deleted SHIVs
23. Regulation of allergic inflammation and eosinophil recruitment in mice lacking the transcription factor NFAT1: Role of interleukin-4 (IL-4) and IL-5
24. Selective inhibition of IL-5 receptor α-chain gene transcription by IL-5, IL-3, and granulocyte-macrophage colony-stimulating factor in human blood eosinophils
25. Diminished HIV-specific CTL activity is associated with lower type 1 and enhanced type 2 responses to HIV-specific peptides during perinatal HIV infection