Glucocorticoids and the thymus: The view from the middle of the road

Trends in Immunology

Volumn 22, Issue 5, 2001, Pages 243-

  Godfrey, Dale I ^a   Purton, Jared F ^a,b   Boyd, Richard L ^a   Cole, Timothy J ^b  

^a MONASH UNIVERSITY   (Australia)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; COMPLEMENTARY RNA; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR;

APOPTOSIS; CELL MATURATION; CELL SELECTION; CELLULAR DISTRIBUTION; DIMERIZATION; LETTER; MUTANT; NONHUMAN; ORGAN CULTURE; ORGANOGENESIS; PROMOTER REGION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOCYTE; THYMUS; TRANSGENIC MOUSE;

EID: 0034921256     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(01)01916-0     Document Type: Letter

References (12)

1. Intrathymic T-cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling
2. Stress free T-cell development: Glucocorticoids are not obligatory
3. Do glucocorticoids participate in intrathymic T-cell development?
4. Reply to Ashwell, Vacchio and Galon
5. A role for glucocorticoids in the thymus?
6. Steroid production in the thymus: Implications for thymocyte selection
7. A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development
8. Thymus-derived glucocorticoids regulate antigen-specific positive selection
9. Thymus-derived glucocorticoids set the thresholds for thymocyte selection by inhibiting TCR-mediated thymocyte activation
10. Inhibition of I-Ad-, but not Db-restricted peptide-induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T-cell receptor transgenic mice
11. DNA binding of the glucocorticoid receptor is not essential for survival
12. Partial blockade of T-cell differentiation during ontogeny and marked alterations of the thymic microenvironment in transgenic mice with impaired glucocorticoid receptor function