Pathophysiological roles of endogenous endothelin-1 in dogs with chronic heart failure produced by rapid right ventricular pacing

Journal of Pharmacology and Experimental Therapeutics

Volumn 298, Issue 2, 2001, Pages 729-736

  Tadano, Kiyoshi ^a   Suzuki, Jun ^a   Hanada, Kayoko ^a   Nakao, Mizuki ^a   Nakao, Rumi ^a   Uehara, Sayuri ^a   Ohta, Hisashi ^a   Miyauchi, Takashi ^b   Nishikibe, Masaru ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 BUTYL 7 [2 (2 CARBOXYPROPYL ) 4 METHOXYPHENYL] 5 (3,4 METHYLENEDIOXYPHENYL)CYCLOPENTENO[1,2 B]PYRIDINE 6 CARBOXYLIC ACID; ALDOSTERONE; ATRIAL NATRIURETIC FACTOR; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENALAPRILAT; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; NORADRENALIN; SARAFOTOXIN S6C; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG POTENTIATION; HEART FAILURE; HEART OUTPUT; HEART RATE; HEART RIGHT VENTRICLE; HEART VENTRICLE PACING; KIDNEY BLOOD FLOW; LUNG ARTERY PRESSURE; LUNG CAPILLARY PRESSURE; M MODE ECHOCARDIOGRAPHY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PATHOPHYSIOLOGY; PLASMA; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR DENSITY; VASCULAR RESISTANCE;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; CARDIAC PACING, ARTIFICIAL; CHRONIC DISEASE; DOGS; ECHOCARDIOGRAPHY; ENALAPRILAT; ENDOTHELIN-1; HEART FAILURE, CONGESTIVE; HEART VENTRICLES; HEMODYNAMIC PROCESSES; PYRIDINES; RECEPTORS, ENDOTHELIN; TISSUE DISTRIBUTION;

EID: 0034917489     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Endothelin converting-enzyme-1 mRNA expression in human cardiovascular disease
2. Characterization of canine renal endothelin receptor subtypes and their function
3. Endothelin in experimental congestive heart failure in the anesthetized dog
4. The role of endothelin in congestive heart failure
5. Reduced pulmonary metabolism of endothelin-1 in canine tachycardia-induced heart failure
6. Endothelin biphasic effect on fluid absorption in the proximal straight tubule and its inhibitory cascade
7. Endothelin, ETA and ETB receptors cause vasoconstriction of human resistance and capacitance vessels in vivo
8. Increased cardiac and pulmonary endothelin-1 mRNA expression in canine pacing-induced heart failure
9. Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure
10. Activation of cardiorenal and pulmonary tissue endothelin-1 in experimental heart failure
11. Increased endothelin in experimental heart failure
12. Effects of sarafotoxin S6c on renal hemodynamics and urine formation in anesthetized dogs
13. Plasma endothelin in chronic heart failure
14. Pharmacological properties of J-104132 (L-753,037), a potent, orally active, mixed ETA/ETB endothelin receptor antagonist
15. Comparison of the acute effects of a selective endothelin ETA and a mixed ETA/ETB receptor antagonist in heart failure
16. Endogenous endothelin-1 depresses left ventricular systolic and diastolic performance in congestive heart failure
17. Evidence for endothelin-induced renal vasoconstriction independent of ETA receptor activation
18. Increased plasma concentration of endothelin in congestive heart failure in humans
19. Inhibition of myocardial endothelin pathway improves long-term survival in heart failure
20. Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure
21. Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels
22. Short-term hemodynamic effects of endothelin receptor blockade in dogs with chronic heart failure
23. Endothelin induction of inositol phospholipid hydrolysis, sacromere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy
24. Cellular and molecular alterations in the β adrenergic system with cardiomyopathy induced by tachycardia
25. Short-term oral endothelin-receptor antagonist therapy in conventionally treated patients with symptomatic severe chronic heart failure
26. Acute effects of E-3174, a human active metabolite of losartan, on the cardiovascular system in tachycardia-induced canine heart failure
27. A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts
28. Potent vasoconstriction mediated by endothelin ETB receptors in canine coronary arteries
29. Different localization of two types of endothelin receptor mRNA in microdissected rat nephron segments using reverse transcription and polymerase chain reaction assay
30. Effects of endothelin on peptide-dependent cyclic adenosine monophosphate accumulation along the nephron segments of rat
31. Comparison of the effects of selective endothelin ETA and ETB receptor antagonists in congestive heart failure
32. Atrial and pulmonary endothelin mRNA is increased in a canine model of chronic low cardiac output
33. Hemodynamic determinations of the time-course of fall in canine left ventricular pressure
34. The endothelin system: A new target for therapeutic intervention