Substance P endopeptidase-like activity is altered in various regions of the rat central nervous system during morphine tolerance and withdrawal

Neuropharmacology

Volumn 41, Issue 2, 2001, Pages 246-253

  Zhou, Qin ^a   Karlsson, Krister ^a   Liu, Zhurong ^a   Johansson, Pia ^a   Le Grevés, Madeleine ^a   Kiuru, Anne ^a   Nyberg, Fred ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Dependence; Morphine; Rat brain; Substance P; Substance P endopeptidase (SPE); Substance P N terminal fragment; Tolerance; Withdrawal

Indexed keywords

MORPHINE; NALOXONE; PROTEINASE; SODIUM CHLORIDE; SUBSTANCE P; SUBSTANCE P [1-7]; SUBSTANCE P ENDOPEPTIDASE; TISSUE EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORPUS STRIATUM; DRUG WITHDRAWAL; ENZYME ACTIVITY; MALE; MEASUREMENT; MODULATION; MORPHINE TOLERANCE; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; REGULATORY MECHANISM; SPINAL CORD; SUBSTANTIA NIGRA; VENTRAL TEGMENTUM;

ANIMALS; CENTRAL NERVOUS SYSTEM; DRUG TOLERANCE; MALE; METALLOENDOPEPTIDASES; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; NARCOTICS; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANCE P; SUBSTANCE WITHDRAWAL SYNDROME; VENTRAL TEGMENTAL AREA;

EID: 0034909028     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00055-7     Document Type: Article

References (36)

1. Morphine withdrawal syndrome: Differential participation of structures located within the amygdaloid complex and the striatum of the rat
2. Effect of nonpeptide NK-1 receptor antagonist CP-96,245 on the morphine withdrawal response of guinea pigs
3. Neurobiology of opiate abuse
4. Behavioural effects of tachykinins and related peptides
5. Reversed-phase high-performance liquid chromatography combined with tandem mass spectrometry in studies of a substance P-converting enzyme from human cerebrospinal fluid
6. The substance P fragment SP(1-7) stimulates motor behaviour and nigral dopamine release
7. The substance P(1-7) fragment is a potent modulator of substance P action in the brain
8. Genetic difference in morphine sensitivity, tolerance and withdrawal in rats
9. Neuropeptide converting enzyme activities in CSF of low back pain patients
10. Specific binding of substance P aminoterminal heptapeptide (SP(1-7) to mouse brain and spinal cord membranes
11. Neurokinin-1, -2 and -3 receptors are candidates for a role in the opiate withdrawal response in guinea-pigs
12. Neural systems for behavioural activation and reward
13. Purification and characterization of substance P endopeptidase activities in the rat spinal cord
14. Behavioural analysis of the effect of substance P injected into ventral mesencephalon on investigatory and spontanous motor behaviour in the rat
15. Drugs of abuse: Anatomy, pharmacology and function of reward pathways
16. Substance P(1-7), a substance P metabolite, inhibits withdrawal jumping in morphine-dependent mice
17. The substance P amino-terminal metabolite substance P(1-7), administered peripherally, prevents the development of acute morphine tolerance and attenuates the expression of withdrawal in mice
18. Drug dependence: Stress and dysregulation of brain reward pathways
19. DAMGO binding to mouse brain membranes: Influence of salts, guanine nucleotides, substance P, and substance P fragments
20. Neuropeptide-converting enzymes in cerebrospinal fluid: Activities are increased in pain from herniated lumbar disc, but not from coxarthrosis
21. Elevated cerebrospinal fluid level of substance P and decreased undecapeptidase activity at term pregnancy
22. RP 67580, a selective antagonist of neurokinin-1 receptors, modifies some of the naloxone-precipitated morphine withdrawal signs in rats
23. Rewarding effects of opiates are absent in mice lacking the receptor for substance P
24. Characterisation of substance P(1-7) and (1-8) generating enzyme in human cerebrospinal fluid
25. Pharmacological studies on lappaconitine: Antinociception and inhibition of the spinal action of substance P and somatostatin
26. Increased neuropeptide-converting enzyme activities in cerebrospinal fluid of opiate-tolerant rats
27. Decreased neuropeptide-converting enzyme activities in cerebrospinal fluid during acute but not chronic phases of collagen induced arthritis in rats
28. Neuropeptide converting and processing enzymes in the spinal cord and cerebrospinal fluid
29. Nociceptin-induced scratching, biting and licking in mice: Involvement of spinal NK1 receptors
30. Captopril and capsaicin modify opioid withdrawal in the morphine dependent rat
31. Neuropharmacology of brain-stimulation-evoked aggression
32. A fragment of substance P with specific central activity: SP (1-7)
33. Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal
34. Assessment of precipitated abstinence in morphine-dependent rats
35. Alteration in the brain level of the substance P (1-7) fragment during withdrawal in morphine-dependent rats
36. Intracerebroventricular injection of the N-terminal substance P fragment SP1-7 regulates the expression of the N-methyl-D-aspartate receptor NR1, NR2A and NR2B subunit mRNAs in the rat brain