Neuropeptide-converting enzymes in cerebrospinal fluid:Activities increased in pain from herniated lumbar disc, but not from coxarthrosis

Acta Orthopaedica

Volumn 67, Issue 2, 1996, Pages 189-192

  Lindh, Christer ^a   Thörnwall, Madeleine ^a   Hansen, Ann Cathrin ^a   Post, Claes ^a   Gordh, Torsten ^a   Ordeberg, Gunnar ^a   Nyberg, Fred ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; DYNORPHIN; NEUROPEPTIDE; PROTEINASE; SUBSTANCE P;

ADULT; AGED; ARTHROPLASTY; ARTICLE; BACKACHE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HIP OSTEOARTHRITIS; HUMAN; ISCHIALGIA; LUMBAR DISK HERNIA; MALE; PAIN ASSESSMENT;

ADULT; AGED; AGED, 80 AND OVER; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; FEMALE; HUMANS; INTERVERTEBRAL DISK DISPLACEMENT; MALE; MIDDLE AGED; OSTEOARTHRITIS, HIP; PAIN MEASUREMENT; PEPTIDYL-DIPEPTIDASE A;

EID: 0029920597     PISSN: 17453674     EISSN: 17453682     Source Type: Journal    
DOI: 10.3109/17453679608994670     Document Type: Article

References (18)

1. Almay B G L, Johansson F, von Knorring L, Sakurada T, Terenius L. Long-term high-frequency transcutaneous electrical nerve stimulation (hi-TENS) in chronic pain. Clinical response and effects on CSF. Endorphins, monoamine metabolites, substance P-like immunoreactivity (SPLI) and pain measures, J Psychosom Res 1985; 29: 247-57. (Pubitemid 15030346)
2. Arnér S. Differentiation of pain and treatment efficacy. Thesis, Karolinska Institute, Stockholm, Sweden 1991.
3. Fields H L, Basbaum A I. Endogenous pain control mechanisms. In: Textbook of Pain (Eds. Wall P D, Melzack R). Churchill Livingstone, Edinburgh London Melbourne New York 1989; 206-17.
4. Grond S. Prävalenz und Charakteristik neuropathischer Schmerzen bei malignen Erkrankungen. Der Schmerz 1992; 6: 99-104.
5. Hyyppä M T, Alaranta H, Lahtela K, Nykvist F, Hume M, Nyberg F, Le Greves P, Sakurada T, Terenius L. Neuropeptide- converting enzyme activities in CSF of lowback pain patients. Pain 1990; 43: 163-8. (Pubitemid 20385180)
6. ladordla M J, Brady L S, Draisci G, Dubner R. Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioural parameters and opioid binding. Pain 1988; 35: 313-26. (Pubitemid 19010487)
7. Lantz I, Thörnwall M, Kihlstrom J-E, Nyberg F. A comparison of human lung, brain, CSF and plasma angiotensinconverting enzyme with regard to neuropeptide metabolism. Biochem Int 1992; 26: 415-26.
8. Nyberg F. CSF opioids in pathophysiology. In: Handhook of Experimental Pharmacology (Eds. Herz A, Akil H, Simon E J). Springer-Verlag Berlin Heidelberg 1993; 104/11: 653-72.
9. Nyberg F, Wahlstrom A, Sjolund B, Terenius L. Characterization of electrophoretically separable endorphins in human CSF. Brain Res 1983; 259: 267-74. (Pubitemid 13176130)
10. Nyberg F, Le Grevés P, Sundqvist C, Terenius L. Characterization of substance P (1-7) and (1-8) generating enzyme in human cerebrospinal fluid. Biochem Biophys Res Commun 1984; 125: 244-50. (Pubitemid 15215872)
11. Nyberg F, Nordstrom K, Terenius L. Endopeptidase in human cerebrospinal fluid which cleaves proenkephalin B opioid peptides at consecutive basic amino acids. Biochern Biophys Res Commun 1985; 131: 1069-74. (Pubitemid 16234293)
12. Nyberg F, VaerØiy H, Terenius L. Opioid peptides and substance P in the cerebrospinal fluid. Regulation and significance to pain. In: Basic Mechanisms of Headache (Eds. Olesen J, Edvinsson L). Elsevier Science Publishers B.V. Amsterdam 1988; 241-58.
13. Persson S, Post C, Holmdahl R, Nyberg E Decreased neuropeptide- converting enzyme activities in cerebrospinal fluid during the acute but not the chronic phases of collagen- induced arthritis in rats. Brain Res 1992; 581: 273-82.
14. Silberring J, Sakurada T, Nyberg F. Dynorphin-converting enzyme in the rat spinal cord. Decreased activities during acute phase of adjuvant-induced arthritis. Life Sci 1992; 50: 839-47.
15. Spillantini M G, Panconesi A, Del Bianco P L, Sicuteri F. Enkephalinase and angiotensin-converting enzyme activities in human venous and arterial plasma. Neuropeptides 1986; 8 (2): 111-7. (Pubitemid 17185704)
16. Terenius L, Nyberg F. Peptidases and proteases in cerebrospinal fluid. Significance in volume transmission. In: Volume Transmission in the Brain. Novel Mechanisms for Neural Transmission (Eds. Fuxe K, Agndti F). Raven Press New York, 1991; 415-24.
17. Thörnwall M, Schwarzmayr S, Almay B, Post C, Vmøy H, Nyberg F. Dynorphin-converting enzyme in human cerebrospinal fluid. A negative correlation between activity and levels of prodynorphin-derived opioid peptides. Regul Peptides (Suppl 1) 1994; 155-6.
18. Yaksh T L, Aimone L D. The central pharmacology of pain transmission. In: Textbook of Pain (Eds. Wall P D, Melzack R). Churchill Livingstone, Edinburgh London Melbourne New York 1989; 181-205.