Cyclooxygenease-2 and hepatocellular carcinoma: Is it a target for prevention?

Clinical Cancer Research

Volumn 7, Issue 5, 2001, Pages 1110-1111

  DuBois, R N ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR;

COLORECTAL CANCER; EDITORIAL; ENZYME ACTIVITY; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; PRIORITY JOURNAL; TUMOR VOLUME;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARCINOMA, HEPATOCELLULAR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; ISOENZYMES; LIVER NEOPLASMS; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 0034906308     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (29)

1. Expression of cyclooxygenase-2 in hepatocellular carcinoma and growth inhibition of hepatoma cell lines by a cyclooxygenase-2 inhibitor, NS-398
2. Genomic response to growth factors
3. Early changes in gene expression during liver regeneration: What do they mean?
4. Colorectal cancer and nonsteroidal anti-inflammatory drugs
5. Up-regulation of cyclooxygenase-2 gene expression in human colorectal adenomas and adenocarcinomas
6. Localization of cyclooxygenase-2 in human sporadic colorectal adenoma
7. Characterization of prostaglandin G/H synthase-1 and -2 in rat, dog, monkey, and human gastrointestinal tracts
8. Expression of cyclooxygenase-1 and -2 in human colorectal cancer
9. The role of cyclooxygenases in inflammation, cancer, and development
10. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase-2
11. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential
12. δ716 knockout mice by inhibition of prostaglandin endoperoxide synthase-2 (COX-2)
13. Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas and selective toxicity against Apc mutant embryos
14. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2
15. Celecoxib prevents tumor growth in vivo without toxicity to normal gut: Lack of correlation between in vitro and in vivo models
16. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis
17. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
18. COX-2 expression is induced by UVB exposure in human skin: Implications for the development of skin cancer
19. Expression of cyclooxygenase-2 in human lung carcinoma
20. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer
21. NS398, a selective cyclooxygenase-2 inhibitor, induces apoptosis and down-regulates bcl-2 expression in LNCaP cells
22. Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder
23. Heightened expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-d in human endometrial adenocarcinoma
24. Coordinate regulation of cyclooxygenase-2 and TGF-β1 in hereditary nonpolyposis colorectal cancer and azoxymethane-induced rat colonic tumors
25. Expression of cyclooxygenase-2 in human hepatocellular carcinoma: Relevance to tumor dedifferentiation
26. Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma
27. Cyclooxygenase-2 expression in hepatocellular carcinoma
28. Par-4, a pro-apoptotic gene, is regulated by NSAIDs in human colon cancer cells
29. Apoptosis induced by NS-398, a selective cyclooxygenase-2 inhibitor, in human colorectal cancer cell lines