High plasma homocyst(e)ine levels in elderly Japanese patients are associated with increased cardiovascular disease risk independently from markers of coagulation activation and endothelial cell damage

Atherosclerosis

Volumn 157, Issue 2, 2001, Pages 441-449

  Kario, Kazuomi ^a   Barton Duell, P ^b   Matsuo, Takefumi ^c   Sakata, Toshiyuki ^d   Kato, Hisao ^d   Shimada, Kazuyuki ^a   Miyata, Toshiyuki ^d  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c HYOGO PREFECTURAL AWAJI HOSPITAL   (Japan)

^d NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Cardiovascular disease; Elderly; Endothelial cell damage; Factor VII; Folate; Homocyst(e)ine; Japanese; Malnutrition; Myocardial infarction; Stroke

Indexed keywords

BIOLOGICAL MARKER; BLOOD CLOTTING FACTOR 7; CHOLESTEROL; CYANOCOBALAMIN; FIBRINOGEN; FOLIC ACID; HOMOCYSTEINE; THROMBOMODULIN;

AGED; AMINO ACID BLOOD LEVEL; ARTICLE; BLOOD CLOTTING; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE ASSOCIATION; ENDOTHELIUM LESION; FEMALE; HUMAN; JAPAN; MALE; NORMAL HUMAN; POPULATION; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR;

AGED; AGED, 80 AND OVER; AGING; ASIAN CONTINENTAL ANCESTRY GROUP; BIOLOGICAL MARKERS; BLOOD COAGULATION; CARDIOVASCULAR DISEASES; ENDOTHELIUM, VASCULAR; FACTOR VIIA; FEMALE; HOMOCYSTEINE; HUMANS; JAPAN; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PROTHROMBIN; RISK FACTORS;

EID: 0034905681     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(00)00738-3     Document Type: Article

References (37)

1. Prevalence of hyperhomocyst(e)inemia in patients with peripheral arterial occlusive disease
2. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida
3. Hyperhomocyst(e)inemia and low pyridoxal phosphate, common and independent reversible risk factors for coronary artery disease
4. Homocyst(e)ine and risk of atherosclerosis: A clinical approach to evaluation and management
5. Homocysteine as a risk factor for coronary artery disease
6. Plasma homocysteine concentrations and risk of coronary heart disease in UK Indian Asian and European men
7. Hyperhomocysteinaemia and premature coronary artery disease in the Chinese
8. Plasma sulfhydryl-containing amino acids in patients with cerebral infarction and in hypertensive subjects
9. Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis
10. Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia
11. Effects of age, lipoproteins and hemostatic parameters on the role of hyperhomocyst(e)inemia as a cardiovascular risk factor in men
12. Initiation and regulation of tissue factor-dependent blood coagulation
13. Haemostatic function and ischaemic heart disease: Principal results of the Northwick Park Heart Study
14. Fluorogenic assay of activated factor VII: Plasma factor VIIa levels in relation to arterial cardiovascular diseases in Japanese
15. Factor VII hyperactivity and ischaemic heart disease
16. Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocyst(e)ine
17. An atherogenic stimulus homocyst(e)ine inhibits cofactor activity of thrombomodulin and enhances thrombomodulin expression in human umbilical vein endothelial cells
18. Homocyst(e)ine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor
19. Homocyst(e)ine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells
20. Adverse vascular effects of homocyst(e)ine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen
21. Homocyst(e)ine-respondent genes in vascular endothelial cells identified by differential display analysis
22. Homocysteine-induced inhibition of endothelium-dependent relaxation in rabbit aorta: Role for superoxide anions
23. Acute methionine load-induced hyperhomocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats
24. Homocyst(e)ine inhibits von Willebrand factor processing and secretion by preventing transport from the endoplasmic reticulum
25. Homocyst(e)ine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells
26. Factor VII hyperactivity in the elderly
27. 'Silent' cerebral infarction is associated with hypercoagulability, endothelial cell damage, and high Lp(a) levels in elderly Japanese
28. Soluble thrombomodulin antigen in conditioned medium is increased by damage of endothelial cells
29. Urinary albumin excretion, cardiovascular disease, and endothelial dysfunction in non-insulin-dependent diabetes mellitus
30. The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and the methylenetetrahydrofolate reductase genotype
31. Role of blood pressure, uric acid, and hemorheological parameters on plasma homocyst(e)ine concentration
32. Vitamin status and intake as primary determinations of homocyst(e)inemia in an elderly population
33. Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary artery disease
34. Plasma levels of activated protein C in healthy subjects and patients with previous venous thromboembolism: Relationships with plasma homocysteine levels
35. Prospective study of hemostatic factors and incidence of coronary heart disease: The atherosclerosis risk in communities (ARIC) study
36. Soluble thrombomodulin and endothelial dysfunction in early atherosclerosis
37. Plasma soluble adhesion molecules and endothelium-dependent vascodilation in early human atherosclerosis