Irofulven (6-hydroxymethylacylfulvene, MGI 114) induces caspase 8 and 9-mediated apoptosis in human pancreatic adenocarcinoma cells

Anticancer Research

Volumn 21, Issue 3 B, 2001, Pages 1789-1794

  Wang, W ^a   Waters, S J ^a   MacDonald, J R ^a   Von Hoff, D D ^a   Strodel, W E ^a   Miller, A R ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Apoptosis; Caspase 8 and 9; Irofulven; Pancreatic cancer

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4',6 DIAMIDINO 2 PHENYLINDOLE; 6 HYDROXYMETHYLACYLFULVENE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; IROFULVEN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; ASSAY; CANCER CELL CULTURE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; WESTERN BLOTTING;

AMINO ACID CHLOROMETHYL KETONES; ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; BLOTTING, WESTERN; CASPASE 8; CASPASE 9; CASPASES; COLORING AGENTS; DNA FRAGMENTATION; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; IN SITU NICK-END LABELING; INDOLES; INHIBITORY CONCENTRATION 50; PANCREATIC NEOPLASMS; PROPIDIUM; SESQUITERPENES; TETRAZOLIUM SALTS; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 0034904658     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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