Synthesis and pharmacological activity of metabolites of the 5-HT4 receptor antagonist SB-207266

Bioorganic and Medicinal Chemistry

Volumn 9, Issue 8, 2001, Pages 2119-2128

  Fedouloff, Michael ^a   Hossner, Frank ^a   Voyle, Martyn ^a   Ranson, Jennie ^a   Powles, Jenifer ^a   Riley, Graham ^a   Sanger, Gareth ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDRO N [1 (3 HYDROXYBUTYL) 4 PIPERIDINYLMETHYL] 2H [1,3]OXAZINO[3,2 A]INDOLE 10 CARBOXAMIDE; DRUG METABOLITE; N (1 BUTYL 4 PIPERIDINYLMETHYL) 3,4 DIHYDRO 4 HYDROXY 2H [1,3]OXAZINO[3,2 A]INDOLE 10 CARBOXAMIDE; N (1 BUTYL 4 PIPERIDINYLMETHYL) 3,4 DIHYDRO 7 HYDROXY 2H [1,3]OXAZINO[3,2 A]INDOLE 10 CARBOXAMIDE; PIBOSEROD; SEROTONIN 4 ANTAGONIST; SEROTONIN 4 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; DESCENDING COLON; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; RECEPTOR BLOCKING; STRUCTURE ANALYSIS;

ANIMALS; GUINEA PIGS; HUMANS; INDOLES; PIPERIDINES; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN ANTAGONISTS;

EID: 0034903671     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(01)00120-1     Document Type: Article

References (18)