Pilot study of albendazole in patients with advanced malignancy: Effect on serum tumor markers/high incidence of neutropenia

Oncology

Volumn 61, Issue 1, 2001, Pages 42-46

  Morris, David L ^a,b   Jourdan, Jean Luc ^a   Pourgholami, Mohammad H ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b ST GEORGE HOSPITAL   (Australia)

Author keywords

AFP; Albendazole; CEA; Colorectal cancer; Hepatocellular carcinoma

Indexed keywords

ALBENDAZOLE; ALPHA FETOPROTEIN; ANTIMITOTIC AGENT; CARCINOEMBRYONIC ANTIGEN;

ADULT; ADVANCED CANCER; AGED; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW; CLINICAL ARTICLE; CLINICAL TRIAL; COLORECTAL CANCER; DISEASE MARKER; DRUG TOLERABILITY; FEMALE; FOLLOW UP; HUMAN; LIVER CELL CARCINOMA; LIVER FUNCTION TEST; LIVER METASTASIS; MALE; MITOSIS INHIBITION; NEUTROPENIA; PRIORITY JOURNAL;

ADULT; AGED; ALBENDAZOLE; ANTINEOPLASTIC AGENTS; BLOOD CELL COUNT; CARCINOEMBRYONIC ANTIGEN; CARCINOMA, HEPATOCELLULAR; COLORECTAL NEOPLASMS; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PILOT PROJECTS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 0034903566     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000055351     Document Type: Article

References (18)

1. The efficacy of treatment with albendazole
2. The role of the cytoskeletal protein, tubulin, in the mode of action and mechanism of drug resistance to benzimidazoles
3. Activity of benzimidazole carbamates against L1210 mouse leukaemia cells: Correlation with in vitro tubulin polymerization assay
4. Study of the in vitro bioactivation of albendazole in human liver microsomes and hepatoma cell lines
5. Effects of 2-deoxyglucose on drug-sensitive human breast cancer cells: Toxicity and magnetic resonance spectroscopy studies of metabolism
6. Albendazole in hydatid disease
7. Albendazole: Objective evidence of response in human hydatid disease
8. In vitro and in vivo suppression of growth of hepatocellular carcinoma cells by albendazole
9. Assessment of serial CEA: Determinations to monitor the therapeutic progress and prognosis of metastatic liver disease treated by regional chemotherapy
10. CEA in the evaluation of therapy of primary and metastatic colorectal cancer
11. Ultrastructural changes in Ascaris suum intestine after mebendazole treatment in vivo
12. Mode of action of benzimidazoles
13. Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin
14. The interaction of benzimidazole carbamates with mammalian microtubule protein
15. The binding and subsequent inhibition of tubulin polymerization in Ascaris suum (in vitro) by benzimidazole anthelmintics
16. The effect of antimicrotubule agents on signal transduction pathways of apoptosis: A review
17. Recent progress in the development of tubulin inhibitors as antimitotic antitumor agents
18. Glucose metabolism by adult hepatocytes in primary culture and by cell lines from rat liver