Geranylgeranylacetone promotes induction and secretion of thioredoxin in gastric mucosal cells and peripheral blood lymphocytes

Free Radical Research

Volumn 35, Issue 1, 2001, Pages 23-30

  Dekigai, Hiroshi ^a   Nakamura, Hajime ^a   Bai, Jie ^a   Tanito, Masaki ^a   Masutani, Hiroshi ^a   Hirota, Kiichi ^b   Matsui, Hirofumi ^c   Murakami, Motonobu ^a   Yodoi, Junji ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Ethanol; Gastric mucosal cell; Geranylgeranylacetone; Hydrogen peroxide; Lymphocyte; Thioredoxin

Indexed keywords

ALCOHOL; ANTIULCER AGENT; CHROMIUM 51; CYSTEINE; HYDROGEN PEROXIDE; OXIDOREDUCTASE; SERINE; TEPRENONE; THIOREDOXIN;

ANIMAL CELL; ARTICLE; CELL LYSATE; CELL PROTECTION; CELL TYPE; CHROMIUM 51 RELEASE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; LIVER CELL; MUCOSA CELL; MUTANT; NONHUMAN; OXIDATIVE STRESS; PERIPHERAL LYMPHOCYTE; RAT; STOMACH MUCOSA; SUPERNATANT; WESTERN BLOTTING;

EID: 0034899291     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715760100300561     Document Type: Article

References (28)

1. Antiulcer effect of geranylgeranylacetone, a new acyclic polyisoprenoid on experimentally induced gastric and duodenal ulcers in rats
2. Clinical evaluation of teprenone, a mucosal protective agent, in the treatment of patients with gastric ulcers: A nationwide, multicenter clinical study
3. Effects of geranylgeranylacetone on gastrointestinal secretion in rats
4. Healing-promoting action of teprenone, a new antiulcer agent on acetic acid ulcer in rats
5. Protective action of tetraprenylacetone against ethanol-induced damage in rat gastric mucosa
6. Gastric mucosal hexosamine content in various liver diseases
7. Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa
8. Protection against alcohol-induced gastric mucosal injury by geranylgeranylacetone: Effect of indomethacin
9. Thioredoxin
10. ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction
11. Adult T cell leukemia-derived factor/human thioredoxin protects endothelial F-2 cell injury caused by activated neutrophils or hydrogen peroxide
12. Redox regulation of cellular activation
13. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
14. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating
15. Thioredoxin negatively regulates p38 MAP kinase activation and IL-6
16. Protective activity of adult T cell leukemia-derived factor (ADF) against tumor necrosis factor-dependent cytotoxicity on U937 cells
17. Effect of recombinant human adult T cell leukemia-derived factor on rat lung reperfusion injury
18. Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage
19. Pancreatic beta cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes
20. Geranylgeranylacetone enhances expression of thioredoxin and suppresses ethanol-induced cytotoxicity in cultured hepatocytes
21. Reactive oxygen-reducing and protein-refolding activities of adult T cell leukemia-derived factor/human thioredoxin
22. Redox control of neuronal damage during brain ischemia after middle cerebral artery occlusion in the rat: Immunohistochemical and hybridization studies of thioredoxin
23. Oral administration of geranylgeranylacetone protects rat livers from warm ischemic injury
24. Thioredoxin and thioredoxin reductase show function-related changes in the gastric mucosa: Immunohistochemical evidence
25. Induction of human thioredoxin in cultured human retinal pigment epithelial cells through cyclic AMP-dependent pathway; involvement in the cytoprotective activity of prostaglandin E1
26. Role of thioredoxin family in the redox regulation of oxidative stress response and signalling
27. Release of thioredoxin via the mechanosensitive channel MscL during osmotic downshock of Escherichia coli cells
28. Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway