Evidence of a role for a non-matrix-type metalloproteinase activity in the shedding of syndecan-1 from human myeloma cells

British Journal of Haematology

Volumn 114, Issue 2, 2001, Pages 414-421

  Holen, Ingunn ^a   Drury, Noel L ^a   Hargreaves, Philip G ^a   Croucher, Peter I ^a,b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

ADAM; Metalloproteinase; Myeloma; Shedding; Syndecan 1

Indexed keywords

BATIMASTAT; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; METALLOPROTEINASE; PHORBOL 12 ACETATE 13 MYRISTATE; PROTEIN KINASE C ACTIVATOR; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; SYNDECAN; SYNDECAN 1; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MYELOMA; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANTIBODIES, MONOCLONAL; CELL MEMBRANE; FLOW CYTOMETRY; FLUORESCEIN; HUMANS; IMMUNOHISTOCHEMISTRY; ISOTHIOCYANATES; MEMBRANE GLYCOPROTEINS; METALLOENDOPEPTIDASES; MULTIPLE MYELOMA; PROTEIN KINASE C; PROTEOGLYCANS; STATISTICS, NONPARAMETRIC; STIMULATION, CHEMICAL; SYNDECAN-1; SYNDECANS; TETRADECANOYLPHORBOL ACETATE; TUMOR CELLS, CULTURED;

EID: 0034892903     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.02963.x     Document Type: Article

References (35)

1. Hydroxamate-based metalloproteinase inhibitor blocks shedding of L-selectin adhesion molecule from leukocytes. Functional consequences for neutrophil aggregation
2. Possible regulation of FGF activity by syndecan, an integral membrane heparan sulphate proteoglycan
3. A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
4. Lack of IL-1 secretion from human myeloma cells highly purified by immunomagnetic separation
5. Reed-Sternberg cells of classical Hodgkins disease react with the plasma cell-specific monoclonal antibody B-B4 and express human syndecan-1
6. Syndecans: Multifunctional cell surface co-receptors
7. A metalloproteinase inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes
8. Elevated levels of shed syndecan-1 correlate with tumour mass and decreased matrix metalloproteinase-9 activity in the serum of patients with multiple myeloma
9. Syndecan-1 is a multifunctional regulator of myeloma pathobiology: Control of tumor cell survival, growth and bone differentiation
10. Antigen-driven differentiation of naive Ig-transgenic B cells in vitro
11. Shedding of syndecan-1 and-4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase
12. Processing of tumour necrosis factor-α precursor by metalloproteinases
13. Human myeloma cells shed the interleukin-6 receptor: Inhibition by tissue inhibitor of metalloproteinase-3 and a hydroxamate-based metalloproteinase inhibitor
14. Membrane protein secretases
15. The cysteine-rich domain of Adam-12 supports cell adhesion and triggers signaling events that lead to β1 integrin-dependent cell spreading
16. A metalloprotease-disintegrin, MDC9/meltrinγ/ADAM9 and PKCδ are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor
17. Cell surface proteoglycan of mouse mammary epithelial cells is shed by cleavage of its matrix-binding ectodomain from membrane-associated domain
18. The myeloma cell antigen syndecan-1 is lost by apoptotic myeloma cells
19. Ligand-affinity cloning and structure of a cell surface heparan sulphate proteoglycan that binds basic fibroblast growth factor
20. Heparan sulphate proteoglycans from mouse mammary epithelial cells. Cell surface proteoglycan is a receptor for interstitial collagens
21. Expression of syndecan-1 inhibits cell invasion into type I collagen
22. Regulation of tumour-necrosis factor-α processing by a metalloproteinase inhibitor
23. Cloning of a novel membrane-linked metalloproteinase from human myeloma cells
24. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α
25. Metalloproteinase-mediated regulation of L-selectin levels on leukocytes
26. Cell surface proteoglycan of mammary epithelial cells. Protease releases a heparan sulphate-rich ectodomain from a putative membrane-anchored domain
27. Expression of syndecan-1 regulates human myeloma plasma cell adhesion to type I collagen
28. Lymphocytes - B express lose syndecan as specific stages of differentiation
29. Adhesion of B lymphoid (MPC-11) cells to type I collagen is mediated by the integral membrane proteoglycan, syndecan
30. Cell surface proteoglycan binds mouse mammary epithelial cells to fibronectin and behaves as a receptor for interstitial matrix
31. Serum syndecan-1: A new independent prognostic marker in multiple myeloma
32. Drosophila syndecan conservation of a cell-surface heparan-sulphate proteoglycan
33. The cell surface proteoglycan of mouse mammary epithelial cells. The extracellular domain contains the N-terminus and a peptide sequence present in a conditioned medium proteoglycan
34. A plasmocyte selective monoclonal antibody (B-B4) recognizes syndecan-1
35. Syndecans: Synergistic activators of cell adhesion