Cytotoxic T cells infiltrating a glioma express an aberrant phenotype that is associated with decreased function and apoptosis

Cancer Immunology, Immunotherapy

Volumn 50, Issue 6, 2001, Pages 285-292

  Prins, Robert M ^a   Graf, Martin R ^a   Merchant, Randall E ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; CTL; Glioma; Tumor immunity

Indexed keywords

CASPASE INHIBITOR; CD45 ANTIGEN; LIPOCORTIN 5; MONOCLONAL ANTIBODY CD3; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; GLIOMA; IMMUNOHISTOCHEMISTRY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SPLEEN CELL; TUMOR IMMUNITY;

ANIMALS; ANNEXIN A5; ANTIGENS, CD45; ANTIGENS, CD8; APOPTOSIS; BRAIN NEOPLASMS; DOWN-REGULATION; FEMALE; GLIOMA; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; LYMPHOCYTES, TUMOR-INFILTRATING; RATS; RATS, INBRED F344; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0034892067     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620100202     Document Type: Article

References (42)

1. Tumor antigens recognized by T cells
2. Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction
3. Inhibition of established pancreatic cancers following specific active immunotherapy with interleukin-2 gene-transduced tumor cells
4. Sequential development of structural and functional alterations in T cells from tumor-bearing mice
5. Interactions between lymphocytes, macrophages, and central nervous system cells
6. Immune defects observed in patients with primary malignant brain tumors
7. Development of systemic immunity to glioblastoma multiforme using tumor cells genetically engineered to express the membrane-associated isoform of macrophage colony-stimulating factor
8. Interleukin-6 transduction of a rat T9 glioma clone results in attenuated tumorigenicity and induces glioma immunity in Fischer F344 rats
9. Eradication of established tumors by CD8 T cell adoptive immunotherapy
10. Lymphocyte Traffic to the Brain
11. Gene therapy of metastatic cancer by in vivo retroviral gene targeting
12. Upregulation of surface markers on dying thymocytes
13. Immunobiology of malignant astrocytomas
14. Tumor antigens in astrocytic gliomas
15. Clinical significance of decreased zeta chain expression in peripheral blood lymphocytes of patients with head and neck cancer
16. Patterns of relapse and response to retreatment in patients with metastatic melanoma or renal cell carcinoma who responded to interleukin-2-based immunotherapy
17. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
18. Treatment of intracranial gliomas with bone marrow-derived dendritic cells pulsed with tumor antigens
19. Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption
20. Tumor escape from immune recognition: Loss of HLA-A2 melanoma cell surface expression is associated with a complex rearrangement of the short arm of chromosome 6
21. Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice
22. Apoptotic elimination of peripheral T lymphocytes in patients with primary intracranial tumors
23. T cell receptor-mediated signaling is defective in T cells obtained from patients with primary intracranial tumors
24. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells
25. Immune surveillance against a solid tumor fails because of immunological ignorance
26. Lymphocyte apoptosis induced by Fas ligand- expressing ovarian carcinoma cells. Implications for altered expression of T cell receptor in tumor-associated lymphocytes
27. Absent or low expression of the zeta chain in T cells at the tumor site correlates with poor survival in patients with oral carcinoma
28. Expression of B220 on activated T cell blasts precedes apoptosis
29. Modulation of T-cell function by gliomas
30. + T lymphocytes in peripheral blood of patients with advanced melanoma
31. Spontaneous ex vivo apoptosis of peripheral blood mononuclear cells in patients with head and neck cancer
32. Molecular characterization of defective antigen processing in human prostate cancer
33. Antigen-processing machinery breakdown and tumor growth
34. The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice
35. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
36. Regression of orthotopic brain tumors by cytokine-assisted tumor vaccines primed in the brain
37. Mechanisms of apoptosis in T cells from patients with renal cell carcinoma
38. T cells infiltrating non-Hodgkin's B cell lymphomas show altered tyrosine phosphorylation pattern even though T cell receptor/CD3-associated kinases are present
39. Immune cells in the tumor microenvironment. Mechanisms responsible for functional and signaling defects
40. Cancer therapy using a self-replicating RNA vaccine
41. Fas-mediated suicide of tumor-reactive T cells following activation by specific tumor: Selective rescue by caspase inhibition
42. Induction of apoptosis in mature T cells by tumour necrosis factor