Retinal axon growth cones respond to EphB extracellular domains as inhibitory axon guidance cues

Development

Volumn 128, Issue 15, 2001, Pages 3041-3048

  Birgbauer, E ^a   Oster, S F ^a   Severin, C G ^a   Sretavan, D W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Axon pathfinding; Ephrins; Extracellular domains; Mouse; Retinal axons; Reverse signaling

Indexed keywords

LIGAND; PROTEIN TYROSINE KINASE;

ANIMAL TISSUE; ARTICLE; ASSAY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DATA ANALYSIS; ENVIRONMENT; ENZYME ACTIVITY; GROWTH CONE; MICROPIPETTE; MICROSCOPY; MODEL; MOUSE; MOUSE MUTANT; NERVE FIBER; NONHUMAN; OPTIC DISK; PRIORITY JOURNAL; PROTEIN DOMAIN; RETINA; RETINA GANGLION CELL; SIGNAL TRANSDUCTION;

ANIMALS; CELL MOVEMENT; LAMININ; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; NEURITES; OPTIC DISK; PROTEIN STRUCTURE, TERTIARY; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPHB4; RECEPTORS, EPH FAMILY; RECOMBINANT FUSION PROTEINS; RETINA; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0034890255     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina
2. Violation of cell lineage restriction compartments in the chick hindbrain
3. Graded and lamina-specific distributions of ligands of EphB receptor tyrosine kinases in the developing retinotectal system
4. Unique changes of ganglion cell growth cone behavior following cell adhesion molecule perturbations: A time-lapse study of the living retina
5. Topographic mapping from the retina to the midbrain is controlled by relative but not absolute levels of EphA receptor signaling
6. Tyrosine phosphorylation of transmembrane ligands for Eph receptors
7. Cloning, characterization, and differential expression of MDK2 and MDK5, two novel receptor tyrosine kinases of the eck/eph family
8. The role of laminin and the laminin/fibronectin receptor complex in the outgrowth of retinal ganglion cell axons
9. Expression and tyrosine phosphorylation of Eph receptors suggest multiple mechanisms in patterning of the visual system
10. Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion
11. Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner
12. Tuming of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC
13. Netrin-1 and DCC mediate axon guidance locally at the optic disc: Loss of function leads to optic nerve hypoplasia
14. Unified nomenclature for Eph family receptors and their ligands, the ephrins
15. Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping
16. Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions
17. Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis
18. Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis
19. Nuk controls pathfinding of commissural axons in the mammalian central nervous system
20. Polarized expression of the receptor protein tyrosine kinase Cek5 in the developing avian visual system
21. Reciprocal expression of the Eph receptor Cek5 and its ligand(s) in the early retina
22. Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands
23. Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1
24. Modulation of EphA receptor function by coexpressed ephrinA ligands on retinal ganglion cell axons
25. An ephrin-A-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein
26. A role for the EphA family in the topographic targeting of vomeronasal axons
27. Is astrocyte laminin involved in axon guidance in the mammalian CNS?
28. Eph family receptors and their ligands distribute in opposing gradients in the developing mouse retina
29. Eph receptors and ephrins restrict cell intermingling and communication
30. cAMP-dependent growth cone guidance by netrin-1
31. Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation
32. Neurolin, the goldfish homolog of DM-GRASP, is involved in retinal axon pathfinding to the optic disk
33. The enrichment of a neuronal growth cone collapsing activity from embryonic chick brain
34. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands
35. Topographic mapping: Organising by repulsion and competition?
36. In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins
37. Turning of nerve growth cones induced by neurotransmitters