Potent antitumor effects of CD154 transduced tumor cells in experimental bladder cancer

Journal of Urology

Volumn 166, Issue 3, 2001, Pages 1093-1097

  Loskog, Angelica ^b   Björkland, Anna ^b   Brown, Michael P ^a   Korsgren, Olle ^b   Malmström, Per Uno ^b   Tötterman, Thomas H ^b  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

^b NONE

Author keywords

Adenoviridae; Bladder; Bladder neoplasms; Immunotherapy; Mice

Indexed keywords

ANTIGEN; B7 ANTIGEN; BCG VACCINE; CD4 ANTIGEN; CD40 LIGAND; CD8 ANTIGEN; IMMUNOSTIMULATING AGENT; INTERLEUKIN 12; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLADDER CANCER; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CANCER TRANSPLANTATION; CARCINOGENICITY; CONTROLLED STUDY; GENETIC TRANSDUCTION; HIGH RISK PATIENT; IMMUNOLOGICAL MEMORY; IMMUNOSTIMULATION; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENE; TUMOR CELL; VACCINATION;

EID: 0034889255     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)65928-9     Document Type: Article

References (29)

1. Biology and management of bladder cancer
2. BCG immunotherapy of bladder cancer: 20 years on
3. T-cell subsets required for intravesical BCG immunotherapy for bladder cancer
4. Five-year follow-up of a randomized prospective study comparing mitomycin-C and bacillus Calmette-Guérin in patients with superficial bladder carcinoma
5. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity
6. Regression of bladder tumors in mice treated with interleukin-2 gene-modified tumor cells
7. Immunotherapy of bladder cancer with cytokine gene modified tumor vaccines
8. + T lymphocytes by B7, a natural ligand for CD28, can be used to treat established mouse melanoma
9. Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector
10. CD40 ligand induces an antileukemia immune response in vivo
11. Antitumor responses induced by transgenic expression of CD40 ligand
12. Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells
13. Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression
14. A double recombinant adenovirus expressing the costimulatory molecule B7-1 (murine) and human IL-2 induces complete tumor regression in a murine breast adenocarcinoma model
15. Antitumor effect of CD40 ligand: Elicitation of local and systematic antitumor responses by IL-12 and B7
16. Gene transfer of CD40 ligand induces autologous immune recognition of chronic lymphocytic leukemia B-cells
17. Anti-tumor immunity induced by in vivo adenovirus vector-mediated expression of CD40L in tumor cells
18. A reassessment of the role of B7-1 expression in tumor rejection
19. Expression of B7-1 by highly metastatic mouse T lymphomas induces optimal natural killer cell-mediated cytotoxicity
20. Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for the IL-12 heterodimer and its inhibition by the IL-12 p4 subunit homodimer
21. Synergistic antitumor effects of interleukin-12 gene transfer and systemic administration of interleukin-18 in a mouse bladder cancer model
22. Effects of donor age on neoplastic transformation of adult mouse bladder epithelium in vitro
23. High-efficiency transduction of freshly isolated human tumor cells using adenoviral interleukin-2 vectors
24. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes
25. + T cells responses
26. Induction of IL-12 p40 messenger RNA expression and IL-12 production of macrophages via CD40-CD40 ligand interaction
27. + T cell responses in antitumor immunity
28. CD40 and epithelial cells: Across the great divide