Disruption of a gene encoding a putative γ-butyrolactone-binding protein in Streptomyces tendae affects nikkomycin production

Applied Microbiology and Biotechnology

Volumn 56, Issue 3-4, 2001, Pages 414-419

  Engel, P ^a   Scharfenstein, L L ^a   Dyer, J M ^a   Cary, J W ^a  

^a SOUTHERN REGIONAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; ERYTHROMYCIN; GAMMA BUTYROLACTONE; HELIX LOOP HELIX PROTEIN; NIKKOMYCIN;

BIOTECHNOLOGY;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM MUTANT; GENE DISRUPTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR CLONING; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PROTEIN SYNTHESIS; SEQUENCE HOMOLOGY; SOUTHERN BLOTTING; STREPTOMYCES; STREPTOMYCES TENDAE; TRANSPOSON;

4-BUTYROLACTONE; AMINO ACID SEQUENCE; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; DEOXYRIBONUCLEASE BAMHI; DNA TRANSPOSABLE ELEMENTS; DNA-BINDING PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; SEQUENCE ANALYSIS, DNA; STREPTOMYCES;

EID: 0034888604     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002530100621     Document Type: Article

References (14)

1. Molecular characterization of co-transcribed genes from Streptomyces tendae Tü901 involved in the biosynthesis of the peptidyl moiety of the peptidyl nucleoside antibiotic nikkomycin
2. Plasmid transformation of Streptomyces tendae after heat attenuation of restriction
3. Use of Tn4560 to generate nikkomycin non-producing mutants of Streptomyces tendae
4. Partial deletion of transposon Tn4560 integrated into the genome of Streptomyces tendae
5. Gene disruption and gene replacement in Streptomyces via single stranded DNA transformation of integration vectors
6. FramePlot: A new implementation of the Frame analysis for predicting protein-coding regions in bacterial DNA with a high G+C content
7. Characterization of binding sequences for butyrolactone autoregulator receptors in streptomycetes
8. In vitro analysis of the butyrolactone autoregulator receptor protein (FarA) of Streptomyces lavendulae FRI-5 reveals that FarA acts as a DNA-binding transcriptional regulator that controls its own synthesis
9. The A-factor-binding protein of Streptomyces griseus negatively controls streptomycin production and sporulation
10. Gene replacement analysis of Streptomyces virginiae barA gene encoding the butyrolactone autoregulator receptor reveals that BarA acts as a repressor in virginiamycin biosynthesis
11. Denaturation of circular or linear DNA facilitates targeted integrative transformation of Streptomyces coelicolor A3(2): Possible relevance to other organisms
12. Nucleotide sequence of Streptomyces fradiae transposable element Tn4556: A class-II transposon related to Tn3
13. Cloning and characterization of the gene (farA) encoding the receptor for an extracellular regulatory factor (IM-2) from Streptomyces sp. strain FRI-5