In vitro analysis of the butyrolactone autoregulator receptor protein (FarA) of Streptomyces lavendulae FRI-5 reveals that FarA acts as a DNA- binding transcriptional regulator that controls its own synthesis

Journal of Bacteriology

Volumn 181, Issue 16, 1999, Pages 5081-5084

  Kitani, Shigeru ^a   Kinoshita, Hiroshi ^a   Nihira, Takuya ^a   Yamada, Yasuhiro ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (HYDROXYBUTYL) 3 (HYDROXYMETHYL)BUTANOLIDE; BUTYROLACTONE; DEOXYRIBONUCLEASE I; DNA BINDING PROTEIN; LACTONE DERIVATIVE; NUCLEASE S1; PROTEIN FARA; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CONTROLLED STUDY; ESCHERICHIA COLI; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; STREPTOMYCES LAVENDULAE; TRANSCRIPTION REGULATION; TRANSLATION INITIATION;

STREPTOMYCES LAVENDULAE;

EID: 0032864203     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.181.16.5081-5084.1999     Document Type: Article

References (28)

1. Bourn, W., and B. Babb. 1995. Computer assisted identification and classification of Streptomyces promoters. Nucleic Acids Res. 23:3696-3703.
2. Gräfe, U., F. Reinhardt, W. Schade, I. Eritt, W. F. Fleck, and L. Radics. 1983. Interspecific inducers of cytodifferentiation and anthracycline biosynthesis from Streptomyces bikiniensis and S. cyaneofuscatus. Biotechnol. Lett. 5:591-596.
3. Gräfe, U., W. Schade, I. Eritt, W. F. Fleck, and L. Radics. 1982. A new inducer of anthracycline biosynthesis from Streptomyces viridochromogenes. J. Antibiot. 35:1722-1723.
4. Guilfoile, P. G., and C. R. Hutchinson. 1992. The Streptomyces glaucescens TcmR protein represses transcription of the divergently oriented tcmR and tcmA genes by binding to an intergenic operator region. J. Bacteriol. 174: 3659-3666.
5. Hashimoto, K., T. Nihira, S. Sakuda, and Y. Yamada. 1992. IM-2, a butyrolactone autoregulator, induces production of several antibiotics in Streptomyces sp. FRI-5. J. Ferment. Bioeng. 73:449-455.
6. Hopwood, D. A., M. J. Bibb, K. F. Chater, T. Kieser, C. J. Bruton, H. M. Kieser, D. J. Lydiate, C. P. Smith, J. M. Ward, and H. Schrempf. 1985. Genetic manipulation of Streptomyces: a laboratory manual. The John Innes Foundation, Norwich, United Kingdom.
7. Janssen, G. R., J. M. Ward, and M. J. Bibb. 1989. Unusual transcriptional and translational features of the aminoglycoside phosphotransferase gene (aph) from Streptomyces fradiae. Genes Dev. 3:415-429.
8. Khokhlow, A. S. 1980. Problems of studies of specific cell autoregulators (on the example of substances produced by some actinomycetes, p. 201-210. In S. N. Ananchenko (ed.), Frontiers of bioorganic chemistry and molecular biology. Pergamon Press, Oxford, United Kingdom.
9. Kinoshita, H., H. Ipposhi, S. Okamoto, H. Nakano, T. Nihira, and Y. Yamada. 1997. Butyrolactone autoregulator receptor protein (BarA) as a transcriptional regulator in Streptomyces virginiae. J. Bacteriol. 179:6986-6993.
10. Kleiner, E. M., S. A. Pliner, V. S. Soifer, V. V. Onoprienko, T. A. Blashova, B. V. Rosynov, and A. S. Khokhlov. 1976. The structure of A-factor, a bioregulator from Streptomyces griseus. Bioorg. Khim. 2:1142-1147.
11. Kondo, K., Y. Higuchi, S. Sakuda, T. Nihira, and Y. Yamada. 1989. New virginiae butanolides from Streptomyces virginiae. J. Antibiot. 42:1873-1876.
12. Miyake, K., S. Horinouchi, M. Yoshida, N. Chiba, K. Mori, N. Nogawa, N. Morikawa, and T. Beppu. 1989. Detection and properties of A-factor-binding protein from Streptomyces griseus. J. Bacteriol. 171:4298-4302.
13. Mizuno, K., S. Sakuda, T. Nihira, and Y. Yamada. 1994. Enzymatic resolution of 2-acyl-3-hydroxymethyl-4-butanolide and preparation of optically active IM-2, the autoregulator from Streptomyces sp. FRI-5. Tetrahedron 50: 10849-10858.
14. Mori, K. 1983. Revision of the absolute configuration A-factor. Tetrahedron 39:3107-3109.
15. Murray, M. G. 1986. Use of sodium trichloroacetate and mung bean nuclease to increase sensitivity and precision during transcript mapping. Anal. Biochem. 158:165-170.
16. Nihira, T., Y. Shimizu, H. S. Kim, and Y. Yamada. 1988. Structure-activity relationship of virginiae butanolide C, an inducer of virginiamycin production in Streptomyces virginiae. J. Antibiot. 41:1828-1837.
17. Okamoto, S., K. Nakamura, T. Nihira, and Y. Yamada. 1995. Virginiae butanolide binding protein from Streptomyces virginiae: evidence that VbrA is not the virginiae butanolide binding protein and reidentification of the true binding protein. J. Biol. Chem. 270:12319-12326.
18. Onaka, H., N. Ando, T. Nihira, Y. Yamada, T. Beppu, and S. Horinouchi. 1995. Cloning and characterization of the A-factor receptor gene from Streptomyces griseus. J. Bacteriol. 177:6083-6092.
19. Onaka, H., and S. Horinouchi. 1997. DNA-binding activity of the A-factor receptor protein and its recognition DNA sequences. Mol. Microbiol. 24: 991-1000.
20. Retzlaff, L., and J. Distler. 1995. The regulator of streptomycin gene expression, StrR, of Streptomyces griseus is a DNA binding activator protein with multiple recognition sites. Mol. Microbiol. 18:151-162.
21. Ruengjitchatchawalya, M., T. Nihira, and Y. Yamada. 1995. Purification and characterization of the IM-2-binding protein from Streptomyces sp. strain FRI-5. J. Bacteriol. 177:551-557.
22. Sakuda, S., and Y. Yamada. 1991. Streochemistry of butyrolactone autoregulators from Streptomyces. Tetrahedron Lett. 32:1817-1820.
23. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
24. Sato, K., T. Nihira, S. Sakuda, M. Yanagimoto, and Y. Yamada. 1989. Isolation and structure of a new butyrolactone autoregulator from Streptomyces sp. FRI-5. J. Ferment. Bioeng. 68:170-173.
25. Waki, M., T. Nihira, and Y. Yamada. 1997. Cloning and characterization of the gene (farA) encoding the receptor for an extracellular regulatory factor (IM-2) from Streptomyces sp. strain FRI-5. J. Bacteriol. 179:5131-5137.
26. White, J., and M. J. Bibb. 1997. bldA dependence of undecylprodigiosin production in Streptomyces coelicolor A3(2) involves a pathway-specific regulatory cascade. J. Bacteriol. 179:627-633.
27. Yamada, Y., K. Sugamura, K. Kondo, M. Yanagimoto, and H. Okada. 1987. The structure of inducing factors for virginiamycin production in Streptomyces virginiae. J. Antibiot. 40:496-504.
28. Yanagimoto, M., and T. Enatsu. 1983. Regulation of a blue pigment production by γ-nonalactone in Streptomyces sp. J. Ferment. Technol. 61:545-550.