Susceptibility to cytomegalovirus infection may be dependent on the cytokine response to the virus

Journal of Investigative Medicine

Volumn 49, Issue 5, 2001, Pages 434-441

  Geist, L J ^a   Hinde, S L ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Cytomegalovirus; Genetic susceptibility; Interleukin 10; Viral infection

Indexed keywords

CYTOKINE; INTERLEUKIN 10; VIRUS DNA; GAMMA INTERFERON; INTERLEUKIN 12P35; INTERLEUKIN 12P40; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 9; MACROPHAGE INFLAMMATORY PROTEIN 2; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOMEGALOVIRUS INFECTION; GENETIC SUSCEPTIBILITY; HUMORAL IMMUNITY; INFECTION SENSITIVITY; LUNG LAVAGE; LYMPHOCYTE COUNT; MOUSE; NONHUMAN; PHENOTYPE; TH2 CELL; VIRUS LOAD; ANIMAL TISSUE; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; LUNG PARENCHYMA; MALE; VIRUS IMMUNITY;

EID: 0034888572     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.2310/6650.2001.33788     Document Type: Article

References (46)

1. Sequelae of cytomegalovirus pulmonary infections in lung allograft recipients
2. Post-transplant obliterative bronchiolitis and other late lung sequelae in human heart-lung transplantation
3. Long-term sequelae after recovery from cytomegalovirus pneumonia in allogeneic bone marrow transplant recipients
4. Interstitial pneumonitis during murine cytomegalovirus infection and graft-versus-host reaction: Effect of ganciclovir therapy
5. Cytomegalovirus infection after bone marrow transplantation: An association with acute graft-v-host disease
6. IL-6: Insights into novel biological activities
7. B-cell activation following murine cytomegalovirus infection: Implications for autoimmunity
8. Antibodies are not essential for the resolution of primary cytomegalovirus infection but limit dissemination of recurrent virus
9. Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration
10. Characterization of early IL-12, IFNalphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection
11. Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones
12. Participation of endogenous tumour necrosis factor alpha in host resistance to cytomegalovirus infection
13. T-lymphocyte effects on murine cytomegalovirus pulmonary infection
14. + T cells contribute to the exacerbation of class I MHC disparate graft-vs-host reaction by concurrent murine cytomegalovirus infection
15. Suppression of normal human hematopoiesis by cytomegalovirus in vitro
16. + lymphocyte depletion on acute murine cytomegalovirus infection
17. Murine cytomegalovirus replication in the lungs of athymic BALB/c nude mice
18. Cellular basis for susceptibility to mouse cytomegalovirus: Evidence from tracheal organ culture
19. Genetically determined resistance to lethal murine cytomegalovirus infection is mediated by interferon-dependent and -independent restriction of virus replication
20. Pathogenesis of acute murine cytomegalovirus infection in resistant and susceptible strains of mice
21. Highresolution linkage map in the proximity of the host resistance locus Cmv 1
22. Genetic mapping of Cmv 1 in the region of mouse chromosome 6 encoding the NK gene complex-associated loci Ly49 and musNKR-P1
23. Murine cytomegalovirus-associated pneumonitis in the lungs free of the virus
24. The immediate early genes of human cytomegalovirus upregulate tumor necrosis factor-alpha gene expression
25. Cytomegalovirus modulates interleukin-6 gene expression
26. The immediate early genes of human cytomegalovirus upregulate expression of the interleukin-2 and interleukin-2 receptor genes
27. Functional characterization of human IL-10
28. Interleukin-10
29. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
30. IL-10 inhibits cytokine production by activated macrophages
31. Interleukin-10 controls interferon- gamma and tumor necrosis factor production during experimental endotoxemia
32. Protective effects of IL-4 and IL-10 against immune complex-induced lung injury
33. IL-10 attenuates excessive inflammation in chronic pseudomonas infection in mice
34. High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells
35. Interleukin-4 and interleukin-10 inhibit nitric oxide-dependent macrophage killing of Candida albicans
36. Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis
37. Human IL- 10 is produced by both type I helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production
38. Interleukin- 10 inhibits apoptotic cell death in infectious mononucleosis T cells
39. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: Homology to Epstein-Barr virus open reading frame BCRFI
40. Epstein-Barr virus recombinants with specifically mutated BCRF1 genes
41. Induction of interleukin- 10 by human immunodeficiency virus type I and its gpl20 protein in human monocytes/macrophages
42. Respiratory syncytial virus induces interleukin-10 by human alveolar macrophages: Suppression of early cytokine production and implications for incomplete immunity
43. Human major group rhinoviruses downmodulate the accessory function of monocytes by inducing IL-10
44. IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2
45. Murine cytomegalovirus infection down-regulates MHC class II expression on macrophages by induction of IL-10
46. Human cytomegalovirus harbors its own unique IL- 10 homolog (cmvIL-10)