Retroviral transduction model of mixed lineage leukemia fused to CREB binding protein

Current Opinion in Hematology

Volumn 8, Issue 4, 2001, Pages 218-223

  Liedman, Donna ^a   Zeleznik Le, Nancy ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; HISTONE ACETYLTRANSFERASE; HYBRID PROTEIN; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; AMINO TERMINAL SEQUENCE; CANCER RESEARCH; CHROMOSOME TRANSLOCATION 11; CHROMOSOME TRANSLOCATION 16; GENETIC TRANSDUCTION; LEUKEMOGENESIS; METHODOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RETROVIRUS; REVIEW; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE;

ANIMALS; ARTIFICIAL GENE FUSION; CREB-BINDING PROTEIN; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; LEUKEMIA, MYELOID; MICE; MYELOID-LYMPHOID LEUKEMIA PROTEIN; MYELOPROLIFERATIVE DISORDERS; NUCLEAR PROTEINS; PROTO-ONCOGENES; RETROVIRIDAE; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSDUCTION, GENETIC;

EID: 0034886441     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-200107000-00007     Document Type: Review

References (34)

1. A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias
2. Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: Identification of 11q23 translocation breakpoints with a yeast artificial chromosome
3. Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA- topoisomerase II
4. The critical role of chromosome translocations in human leukemias
5. Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations
6. Myelodysplastic syndromes associated with 11q23 abnormalities. European 11q23 Workshop participants
7. MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis
8. 11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene
9. Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein
10. Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells
11. The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex
12. Self-association of the SET domains of human ALL-1 and of Drosophila TRITHORAX and ASH1 proteins
13. MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)
14. Novel MLL-CBP fusion transcript in therapy-related chronic myelomonocytic leukemia with a t(11;16)(q23;p13) chromosome translocation
15. The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene
16. Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13)
17. Transcriptional coregulators in development
18. The CBP co-activator is a histone acetyltransferase
19. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
20. Conjunction dysfunction: CBP/p300 in human disease
21. Abnormal skeletal patterning in embryos lacking a single Cbp allele: A partial similarity with Rubinstein-Taybi syndrome
22. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP
23. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300
24. E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators
25. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein
26. Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13)
27. All patients with the t(11,16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders
28. Secondary leukemia or myelodysplastic syndrome after treatment with epipodophyllotoxins
29. Immortalization and leukemic transfermation of a myelomonocytic precursor by retrovirally transduced HRX-ENL
30. Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia
31. Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice
32. Structure and ligand of a histone acetyltransferase bromodomain
33. The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX
34. HATs off: Selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF