Tolerance to the protective effect of salmeterol on allergen challenge can be partially restored by the withdrawal of salmeterol regular treatment

Chest

Volumn 119, Issue 6, 2001, Pages 1671-1675

  Giannini, D ^a   Di Franco, A ^a   Bacci, E ^a   Dente, F L ^a   Bartoli, M L ^a   Vagaggini, B ^a   Paggiaro, P ^a  

^a CISANELLO HOSPITAL   (Italy)

Author keywords

Allergen challenge; Asthma; Tolerance; 2 agonist

Indexed keywords

ALLERGEN; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; METHACHOLINE; SALMETEROL;

ADULT; ALLERGIC ASTHMA; ALLERGY TEST; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG TOLERANCE; DRUG WITHDRAWAL; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INHALATION TEST; MALE; PATIENT SELECTION; PRIORITY JOURNAL; PROTECTION; SINGLE BLIND PROCEDURE;

EID: 0034886307     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.119.6.1671     Document Type: Article

References (29)

1. Tolerance to the bronchoprotective effect of salmeterol on allergen challenge
2. Rapid onset of tolerance to the protective effect of salmeterol
3. Inhaled corticosteroids do not prevent the development of tolerance to the bronchoprotective effect of salmeterol
4. Desensitization of the adrenoceptor of lymphocytes from normal and asthmatic patients in vitro
5. In vitro desensitization of β-adrenergic receptors in human neutrophils: Attenuation by corticosteroids
6. Reversal of human lymphocyte β-adrenoceptor desensitization by glucocorticosteroids
7. 2-sensitivity in alveolar macrophages despite corticosteroid treatment
8. The β-adrenoreceptor
9. 2-adrenoreceptors: Accelerated restoration of β-adrenoreceptor responsiveness by prednisone and ketotifen
10. 2-agonist and inhaled corticosteroid on airway responsiveness to allergen and methacholine
11. 2-agonist
12. Inhaled beclomethasone dipropionate reverts tolerance to the protective effect of salmeterol on allergen challenge
13. 2-adrenoceptor down-regulation after regular inhaled formoterol
14. Pattern of airway response to allergen extract of phleum pratensis in asthmatic patients during and outside the pollen season
15. Determining equivalence of inhaled medications
16. Decreased β-adrenergic receptors on polymorphonuclear leukocytes after adrenergic therapy
17. Decreased mononuclear cell β-adrenergic receptors in bronchial asthma: Parallel studies of lymphocyte and granulocyte desensitization
18. Regular inhaled β-agonist treatment in bronchial asthma
19. Regular inhaled β-agonist in asthma: Effects on exacerbations and lung function
20. Tolerance to β-agonists during acute bronchoconstriction
21. A high dose of albuterol does not overcome bronchoprotective subsensitivity in asthmatic subjects receiving regular salmeterol or formoterol
22. Effects of long-acting and short-acting β-agonists on methacholine dose-response curves in asthmatics
23. 2-adrenoceptor agonist, salmeterol, on airway hyperresponsiveness in patients with mild asthma
24. Tolerance to the nonbronchodilator effects of inhaled β-agonists in asthma
25. Regular inhaled salbutamol and airway responsiveness to allergen
26. Reduced protection against exercise induced bronchoconstriction after chronic dosing with salmeterol