The effect of handling techniques on electrostatic charge on spacer devices: A correlation with in vitro particle size analysis

International Journal of Pharmaceutics

Volumn 137, Issue 2, 1996, Pages 261-264

  Dewsbury, N J ^a   Kenyon, C J ^a   Newman, S P ^a  

^a PHARMACEUTICAL PROFILES LTD   (United Kingdom)

Author keywords

Handling techniques; Respirable fraction; Spacers; Static charge

Indexed keywords

BRONCHODILATING AGENT; SALBUTAMOL;

AEROSOL; ARTICLE; DRUG DELIVERY SYSTEM; ELECTRICITY; IN VITRO STUDY; INHALATIONAL DRUG ADMINISTRATION; PARTICLE SIZE; PRIORITY JOURNAL; TECHNIQUE;

EID: 0030604708     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(96)04500-0     Document Type: Article

References (5)

1. Barry, P.W. and O'Callaghan, C., Poor output salbutamol from a spacer device: effect of spacer static charge and multiple actuations. Thorax, 49 (1994) 402.
2. Newman, S.P., Aerosol generators and delivery systems. Respir. Care, 36 (1991) 939-951.
3. Newman, S.P., Millar, A.B., Lennard-Jones, T.R., Moren, F. and Clarke, S.W., Improvement of pressurised aerosol deposition with Nebuhaler spacer device. Thorax, 39 (1984) 935-941.
4. O'Callaghan, C., Lynch, J., Cant, M. and Robertson, C., Improvement in sodium cromoglycate delivery from a spacer device by use of an antistatic lining, immediate inhalation, and avoiding multiple actuations of drug. Thorax, 48 (1993) 603-606.
5. US Pharmacopeia, Multistage liquid impinger. US Pharmacopeia, 19 (May-June 1993) 5463.