Enoximone in contrast to dobutamine improves hepatosplanchnic function in fluid-optimized septic shock patients

Critical Care Medicine

Volumn 29, Issue 8, 2001, Pages 1519-1525

  Kern, Hartmut ^a   Schröder, Torsten ^a   Kaulfuss, Marco ^a   Martin, Michael ^a   Kox, Wolfgang J ^a   Spies, Claudia D ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Cardiac index; Dobutamine; Enoximone; Hepatic function; Liver blood flow; Monoethylglycinexylidide; Septic shock; Tumor necrosis factor

Indexed keywords

DEETHYLLIDOCAINE; DOBUTAMINE; ENOXIMONE; FENTANYL; FLUNITRAZEPAM; LIDOCAINE; NORADRENALIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG METABOLISM; FLUID THERAPY; HIGH RISK PATIENT; HUMAN; INFLAMMATION; INTENSIVE CARE UNIT; LIVER BLOOD FLOW; LIVER ISCHEMIA; LIVER PERFUSION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REPERFUSION INJURY; SEPTIC SHOCK; SPLANCHNIC BLOOD FLOW; UNIVERSITY HOSPITAL;

EID: 0034883587     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200108000-00004     Document Type: Article

References (53)

1. Gastrointestinal mucosal injury in experimental models of shock, trauma, and sepsis
2. The role of gut mucosal hypoperfusion in the pathogenesis of post-operative organ dysfunction
3. Effect of dobutamine on oxygen consumption and gastric mucosal pH in septic patients
4. Estimation of splanchnic blood flow by the Fick principle in man and problems in the use of indocyanine green
5. Indocyanine green: Its use as an early indicator of hepatic dysfunction following injury in man
6. Cytokines and adhesion molecules in elective and accidental trauma-related ischemia/reperfusion
7. The prognostic value of immune modulating parameters on the progression from peritonitis to septic shock
8. Time course and prognostic significance of hemostatic changes in sepsis: Relation of tumor necrosis factor-alpha
9. Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma
10. Regional effects of dobutamine in endotoxic shock
11. A dobutamine test can disclose hepato-splanchnic hypoperfusion in septic patients
12. Could anti-inflammatory actions of catecholamines explain the possible beneficial effects of supranormal oxygen delivery in critically ill surgical patients?
13. Influence of enoximone on systemic and splanchnic oxygen utilization and endotoxin release following cardiopulmonary bypass
14. Milrinone modulates endotoxemia, systemic inflammation and subsequent acute phase response after cardiopulmonary bypass
15. Vesnarinone and amrinone reduce the systemic inflammatory response syndrome
16. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
17. Regional blood flow and oxygen transport in patients with low cardiac output syndrome after cardiac surgery
18. Determination of monoethylglycinexylidide by fluorescence polarization immunoassay in highly icteric serum samples: Modified precipitation procedure and HPLC compared
19. Monoethylglycinexylidide (MEGX) as an early predictor of liver dysfunction in severe sepsis
20. Measuring lignocaine metabolite monoethylglycinexylidide as a quantitative index of hepatic function in adults with chronic hepatitis and cirrhosis
21. Spontaneous variability of cardiac output in ventilated critically ill patients
22. 2 dependency exist in critically ill septic patients
23. N-acetylcysteine improves indocyanine green extraction and oxygen transport during hepatic dysfunction
24. Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients
25. Reducing the risk of major elective surgery: Randomised controlled trial of preoperative optimisation of oxygen delivery
26. Effect of maximizing oxygen delivery on morbidity and mortality rates in critically ill patients: A prospective, randomized, controlled study
27. A randomized and controlled trial of the effect of treatment aimed at maximizing oxygen delivery in patients with severe sepsis or septic shock
28. Elevation of systemic oxygen delivery in the treatment of critically ill patients
29. A trial of goal-oriented hemodynamic therapy in critically ill patients
30. Splanchnic blood flow is greater in septic shock treated with norepinephrine than in severe sepsis
31. The estimation of hepatic flow in man
32. Estimation of hepatic blood flow with indocyanine green
33. Effects of hemodilution on splanchnic perfusion and hepatorenal function. I. Splanchnic perfusion
34. Effects of hemodilution on splanchnic perfusion and hepatorenal function. II. Renal perfusion and hepatorenal function
35. Variations of surgical reconstruction in liver transplantation depending on vasculature
36. Abnormalities of gastric mucosal oxygenation in septic shock
37. Monitoring the hepato-splanchnic region in the critically ill patient: Measurement techniques and clinical relevance
38. Lignocaine metabolism in human liver microsomes by cytochrome P450IIIA4
39. Clinical pharmacokinetics of lignocaine
40. The lignocaine metabolite (MEGX) liver function test and P-450 induction in humans
41. Effect of erythromycin and itraconazole on the pharmacokinetics of oral lignocaine
42. Lignocaine metabolite formation as a measure of pre-transplant liver function
43. Monoethylglicinexylidide test: A prognostic indicator of survival in cirrhosis
44. N-Acetylcysteine increases liver blood flow and improves liver function in septic shock patients: Results of a prospective, randomized, double-blind study
45. Impact of exogenous beta-adrenergic receptor stimulation on hepato-splanchnic oxygen kinetics and metabolic activity in septic shock
46. Enhancement of hepatic glucose release and bile flow by the phosphodiesterase-III-inhibitor enoximone in the perfused rat liver
47. Effects of selective phosphodiesterase 3 inhibition in the perfused liver of the rat after endotoxin treatment
48. Enoximone inhibits hepatic mitochondrial long-chain acyl-CoA synthetase
49. Serum cardiac troponin T as a prognostic marker in early sepsis
50. Endotoxin and tumor necrosis factor alpha exert a similar proinflammatory effect in neonatal rat cardiomyocytes, but have different cardiodepressant profiles
51. LPS-induced TNF-α release from and apostosis in rat cardiomyocytes: Obligatory role for CD14 in mediating the LPS response
52. Effect of amrinone on tumor necrosis factor production in endotoxic shock
53. Dobutamine restores intestinal mucosal blood flow in a porcine model of intra-abdominal hyperpressure