A novel mutation in islet amyloid polypeptide (IAPP) gene promoter is associated with type II diabetes mellitus [2]

Diabetologia

Volumn 44, Issue 8, 2001, Pages 1064-1065

  Novials, A ^a   Rojas, I ^a   Franco, C ^a   Casamitjana, R ^a   Usac, E F ^a   Gomis, R ^a  

^a HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN;

ADULT; AGED; AMINO ACID SUBSTITUTION; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENE MUTATION; GENOTYPE; GLUCOSE METABOLISM; HETEROZYGOTE; HUMAN; LETTER; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SINGLE STRAND CONFORMATION POLYMORPHISM;

AGED; AMYLOID; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; MALE; MIDDLE AGED; MUTATION; PROMOTER REGIONS (GENETICS);

EID: 0034883323     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250100599     Document Type: Letter

References (8)

1. Islet amyloid polypeptide: A new -cell secretory product related to islet amyloid deposits
2. Islet amyloid: A long recognized but underappreciated pathological feature of type 2 diabetes
3. Missense mutation of amylin gene (S20G) in Japanese NIDDM patients
4. S20G mutant amylin exhibits increased in vitro amyloidogenicity and increased intracellular cytotoxicity compared to wild type amylin
5. Regulation of islet amyloid polypeptide in human pancreatic islets
6. Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide
7. Spontaneous diabetes mellitus in transgenic mice expressing human amyloid polypetide
8. Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic -cells