Probing opioid receptor-ligand interactions by employment of indolizidin-9-one amino acid as a constrained Gly2-Gly3 surrogate in a leucine-enkephalin mimic

Journal of Peptide Research

Volumn 57, Issue 4, 2001, Pages 337-344

  Gosselin, F ^a   Lubell, W D ^a   Tourwe D ^b   Ceusters, M ^c   Meert, T ^c   Heylen, L ^c   Jurzak, M ^c  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^c JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

Azabicyclo X.Y.0 alkane amino acids; Biological activity; Conformational analysis; Indolizidinone amino acid; Leu enkephalin; Peptide mimics

Indexed keywords

[9 OXO 8 N (BUTYLOXYCARBONYL)AMINO 1 AZABICYCLO[4.3.0]NONANE 2 CARBOXYLIC ACID] 2,3 LEUCINE ENKEPHALIN; AMIDE; INDOLIZIDIN 9 ONE AMINO ACID; INDOLIZIDINE DERIVATIVE; LEUCINE ENKEPHALIN[2 GLYCINE 3 GLYCINE]; OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CIRCULAR DICHROISM; CONFORMATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; IN VITRO STUDY; LIGAND BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; RAT; SPINAL ANESTHESIA; STRUCTURE ACTIVITY RELATION; TEMPERATURE;

AMINO ACIDS; ANALGESIA; ANIMALS; CIRCULAR DICHROISM; DIPEPTIDES; ENKEPHALIN, LEUCINE; HUMANS; INDOLIZINES; LIGANDS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; RATS; RECEPTORS, OPIOID;

ANIMALIA;

EID: 0034883263     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1397-002X.2000.00812.x     Document Type: Article

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