Synthesis and analysis of Leu-enkephalin analogues containing reverse turn peptidomimetics

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 4, 1996, Pages 485-490

  Claridge, Timothy D W ^a   Hulme, Christopher ^a   Kelly, Richard J ^a   Lee, Victor ^a   Nash, Ian A ^a   Schofield, Christopher J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENKEPHALIN DERIVATIVE; LEUCINE ENKEPHALIN;

ARTICLE; CHIRALITY; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE;

EID: 0029936675     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00055-8     Document Type: Article

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35. Modelling studies suggest that a close approach of the Gly2 CO and Leu5 NH of (20) occurs if an ideal β-turn is formed, hence distortion would be anticipated to relieve this conflict. For extensive modelling studies on reverse rurn analogues including species containing bicyclic lactams [including (1) and (2)] see Marshall et al., ref. 5.