Receptors and transmission in the brain-gut axis: Potential for novel therapies IV. GABAB receptors in the brain-gastroesophageal axis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 281, Issue 2 44-2, 2001, Pages

  Blackshaw, L Ashley ^a,b  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

^b Matthew Roberts Laboratory   (Australia)

Author keywords

Gastroesophageal reflux; Mechanoreceptors; Transient lower esophageal relaxations; Vagal afferents

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; ACETYLCHOLINE; BRAIN RECEPTOR; G PROTEIN COUPLED RECEPTOR;

BRAIN; BRAIN STEM; ESOPHAGUS; GASTROESOPHAGEAL REFLUX; HUMAN; MECHANORECEPTOR; MOTONEURON; NEUROTRANSMITTER RELEASE; PREGANGLIONIC NERVE; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; REVIEW; SENSORY NERVE; STOMACH; VAGUS NERVE;

EID: 0034880437     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2001.281.2.g311     Document Type: Review

References (30)

1. Modulation of the vagal drive to the intramural cholinergic and non-cholinergic neurones in the ferret stomach by baclofen
2. B receptors: Drugs meet clones
3. GABA(B) receptor isoforms GBR1a and GBR1b, appear to be associated with pre- and post-synaptic elements respectively in rat and human cerebellum
4. B receptors - Peripheral and central targets for controlling gastro-oesophageal reflux
5. GABA(B) receptor-mediated effects on vagal pathways to the lower oesophageal sphincter and heart
6. Inhibition of transient LES relaxations and reflux in ferrets by GABA receptor agonists
7. Peripheral and central sites of action of GABA-B agonists to inhibit the cough reflex in the cat and guinea pig
8. B receptors that mediate inhibition of GABA and glutamate release in human neocortex
9. Cholecystokinin and nitric oxide in transient lower esophageal sphincter relaxation to gastric distention in dogs
10. The actions of baclofen on neurones and synaptic transmission in the nucleus tractus solitarii of the rat in vitro
11. The expression of GABA(B1) and GABA(B2) receptor subunits in the cNS differs from that in peripheral tissues
12. Cholinergic blockade inhibits gastro-oesophageal reflux and transient lower oesophageal sphincter relaxation through a central mechanism
13. 3H-GABA bind to bicuculline-insensitive GABA B sites in rat brain
14. GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2
15. Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors
16. b receptor inhibits transient lower esophageal sphincter relaxations in dogs
17. Control of transient lower esophageal sphincter relaxations and reflux by the GABA(B) agonist baclofen in normal subjects
18. Immunohistochemical localization of GABA(B) receptors in the rat central nervous system
19. Effect of atropine on the frequency of reflux and transient lower esophageal sphincter relaxation in normal subjects
20. Transient lower esophageal sphincter relaxation
21. B receptor directly interacts with the activating transcription factor 4
22. GABA(B) receptors inhibit mechanosensitivity of primary afferent endings
23. Roles of central glutamate, acetylcholine and CGRP receptors in afferent inputs to vagal preganglionic neurones
24. GABA(B) receptors on vagal afferent pathways: Peripheral and central inhibition
25. Effect of morphine on gastroesophageal reflux and transient lower esophageal sphincter relaxation
26. 3 receptors in the control by cholecystokinin of transient relaxations of the inferior esophageal sphincter in dogs
27. 2+ currents in rat nodose ganglion neurons
28. Vagal neurotransmission to the ferret lower oesophageal sphincter: Inhibition via GABA(B) receptors
29. Triggering of transient LES relaxations in ferrets: Role of sympathetic pathways and effects of baclofen
30. B receptors are present at pre- and postsynaptic sites within the rat dorsolateral septal nucleus