Identification of syt-ssx fusion transcripts in both epithelial and spindle cell components of biphasic synovial sarcoma in small tissue samples isolated by membrane-based laser microdissection

Virchows Archiv

Volumn 439, Issue 2, 2001, Pages 152-157

  Nishio, Jun ^a   Iwasaki, Hiroshi ^a   Ishiguro, Masako ^a   Ohjimi, Yuko ^a   Isayama, Teruto ^a   Naito, Masatoshi ^a   Kikuchi, Masahiro ^a  

^a FUKUOKA UNIVERSITY   (Japan)

Author keywords

Biphasic synovial sarcoma; Cold photolysis; Microbeam microdissection of membrane mounted native tissue (MOMeNT); SYT SSX fusion transcript

Indexed keywords

GENE PRODUCT; HYBRID PROTEIN; PROTEIN SSX; PROTEIN SYT; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISSECTION; EPITHELIUM CELL; FEMALE; GENE FUSION; HUMAN; HUMAN TISSUE; LASER; MALE; MICROBEAM MICRODISSECTION OF MEMBRANE MOUNTED NATIVE TISSUE TECHNIQUE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SPINDLE CELL; SYNOVIAL SARCOMA;

ADULT; AGED; AMELOBLASTOMA; BONE NEOPLASMS; DISSECTION; EPITHELIAL CELLS; FEASIBILITY STUDIES; GENE EXPRESSION PROFILING; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION, FLUORESCENCE; LASERS; MALE; MEMBRANES, ARTIFICIAL; MICROMANIPULATION; MIDDLE AGED; ONCOGENE PROTEINS, FUSION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; SARCOMA, SYNOVIAL; SOFT TISSUE NEOPLASMS; TRANSCRIPTION, GENETIC; TUMOR MARKERS, BIOLOGICAL;

EID: 0034879412     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004280100428     Document Type: Article

References (24)

1. Synovial sarcoma specific translocation associated with both epithelial and spindle cell components
2. Microbeam MOMeNT. Non-contact laser microdissection of membrane-mounted native tissue
3. Membrane-based laser microdissection in molecular oncology
4. Translocation t(X;18) in orofacial synovial sarcoma
5. Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in synovial sarcoma
6. Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma
7. Synovial sarcoma. Inter-relationship of the biphasic and monophasic subtypes
8. Distinct Xp11.2 breakpoint regions in synovial sarcoma revealed by metaphase and interphase FISH: Relationship to histologic subtypes
9. Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript
10. Diagnosis of synovial sarcoma with reverse transcriptase-polymerase chain reaction: Analysis of 84 soft tissue and bone tumors
11. Synovial sarcoma of the prostate with t(X;18)(p11.2;q11.2)
12. Detection of SYT-SSX fusion transcripts in both epithelial and spindle cell areas of biphasic synovial sarcoma using laser capture microdissection
13. In situ reverse-transcriptase polymerase chain reaction demonstration of the EWS/FLI-1 fusion transcript in Ewing's sarcomas and peripheral primitive neuroectodermai tumors
14. The emerging molecular genetics of sarcoma translocations
15. Detection of the SYT-SSX fusion transcripts in formaldehyde-fixed, paraffin-embedded tissue: A reverse transcription polymerase chain reaction amplification assay useful in the diagnosis of synovial sarcoma
16. Synovial sarcoma. A misnomer
17. Intravascular synovial sarcoma
18. Coexpression of hepatocyte growth factor and c-Met proto-oncogene product in synovial sarcoma
19. Primary synovial sarcoma of the middle ear
20. Two categories of synovial sarcoma defined by divergent chromosome translocation breakpoints in Xp11.2, with implications for the histologic sub-classification of synovial sarcoma
21. Synovial sarcoma
22. Interphase fluorescence in site hybridization and reverse transcription polymerase chain reaction as a diagnostic aid for synovial sarcoma
23. Detection of SYT-SSX fusion transcripts in synovial sarcoma by reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues
24. Translocation X;18 in synovial sarcoma [letter]