Synovial sarcoma specific translocation associated with both epithelial and spindle cell components

International Journal of Cancer

Volumn 82, Issue 4, 1999, Pages 605-608

  Birdsall, Sandra ^a   Osin, Pinchas ^a   Lu, Yong Jie ^a   Fisher, Cyril ^b   Shipley, Janet ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CHROMOSOME 18; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; CLONOGENESIS; EPITHELIUM CELL; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; SPINDLE CELL; SYNOVIAL SARCOMA; X CHROMOSOME;

ADULT; AGED; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 18; HUMANS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; REPRESSOR PROTEINS; SARCOMA, SYNOVIAL; TRANSLOCATION, GENETIC; X CHROMOSOME;

EID: 0032817116     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990812)82:4<605::AID-IJC22>3.0.CO;2-H     Document Type: Article

References (21)

1. BOVEE, J., VAN DEN BROEK, L., DE BOER, W. and HOGENDOORN, P., Expression of growth factors and their receptors in adamantinoma of long bones and the implication for its histogenesis. J. Pathol., 184, 24-30 (1998).
2. CLARK, J., ROCQUES, P., CREW, A.J., GILL, S., SHIPLEY, J., CHAN, A., GUSTERSON, B.A. and COOPER, C.S., Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in synovial sarcoma. Nature (Genet.), 7, 502-508 (1994).
3. CREW, J., CLARK, J., FISHER, C., GILL, S., GRIMER, R., CHAND, A., SHIPLEY, J., GUSTERSON, B. and COOPER, C., Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. EMBO J., 14, 2333-2340 (1995).
4. DE LEEUW, B., SUIJKERBUIJK, R., OLDE WEGHUIS, D., MELONI, A., STENMAN, G., KINDBLOM, L., BALEMANS, M., VAN DEN BERG, E., MOLENAAR, W., SANDBERG, A.A. and GEURTS VAN KESSEL, A., Distinct Xp11.2 breakpoint regions in synovial sarcoma revealed by metaphase and interphase FISH: relationship to histologie subtypes. Cancer Genet. Cytogenet., 73, 89-94 (1994).
5. DIETRICH, C., PANDIS, N., RIZUO, H., PETERSSON, C., BARDI, G., QVIST, H., APOSTOLIKAS, N., BOHLER, P., ANDERSEN, J., IDVALL, I., MITELMAN, F. and HEIM, S., Cytogenetic findings in phyllodes tumors of the breast: karyotypic complexity differentiates between malignant and benign tumors. Hum. Pathol., 28, 1379-1382 (1997).
6. ENZINGER, F.M. and WEISS, S.W., Soft tissue tumors (3rd ed), pp. 757-786, CV Mosby, St Louis, MO (1995).
7. FISHER, C., Synovial sarcoma: ultrastructural and immunohistochemical features of epithelial differentiation in monophasic and biphasic tumors. Hum. Pathol., 17, 996-1008 (1986).
8. FISHER, C., Synovial sarcoma. Ann. Diagn. Pathol. 2, 401-421 (1998).
9. FLETCHER, J., PINKUS, G., WEIDNER, N. and MORTON, C., Lineage-restricted clonality in biphasic solid tumors. Amer. J. Pathol., 138, 1199-1207 (1991).
10. HALL, P. and LEVISON, D., Biphasic tumours: clues to possible histogenesis in developmental processes. J. Pathol., 159, 1-2 (1989).
11. HIRAGA, H., NOJIMA, T., ABE, S., SAWA, H., YAMASHIRO, K., YAMAWAKI, S., KANEDA, K. and NAGASHIMA, K., Diagnosis of synovial sarcoma with reverse transcriptase-polymerase chain reaction: analysis of 84 soft tissue and bone tumors. Diagn. mol. Pathol., 7, 102-110 (1998).
12. KAWAI, A., WOODRUFF, J., HEALEY, J., BRENNAN, M., ANTONESCU, C. and LADANYI, M., SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N. Engl. J. Med., 338, 153-160 (1998).
13. KOUNELIS, S., JONES, M., PAPADAKI, H., BAKKER, A., SWALSKY, P. and FINKELSTAIN, S., Carcinosarcomas (malignant mixed mullerian tumors) of the female genital tract: comparative molecular analysis of epithelial and mesenchymal components. Hum. Pathol., 29, 82-87 (1998).
14. LU, Y.-J., BIRDSALL, S., SUMMERSGILL, B., SMEDLEY, D., OSIN, P., FISHER, C. and SHIPLEY, J., Dual colour fluorescence in situ hybridisation to paraffin embedded samples to deduce the presence of the der(X)(t(X;18)(p11,2; q11.2) and involvement of either the SSX1 or the SSX2 gene: a diagnostic and prognostic aid for synovial sarcoma. J. Pathol., 187, 490-496 (1999).
15. MITELMAN, F., CATALOG OF CHROMOSOME ABERRATIONS IN CANCER [CD-ROM]. WILEY-LISS, NEW YORK (1998).
16. NOGUCHI, S., MOTOMURA, K., INAJI, H., IMAOKA, S. and KOYAMA, H., Clonal analysis of fibroadenoma and phyllodes tumor of the breast. Cancer Res., 53, 4071-4074 (1993).
17. RENWICK, P., REEVES, B., DAL CIN, P., FLETCHER, C., HEMPSKI, H., SCIOT, R., KAZMIERCZAK, B., JANI, K., SONOBE, H. and KNIGHT, J., Two categories of synovial sarcoma defined by divergent chromosome translocation breakpoints in Xp11.2, with implications for the histologic sub-classification of synovial sarcoma. Cytogenet. Cell Genet., 70, 58-63 (1995).
18. SHIPLEY, J., CREW, J., BIRDSALL, S., GILL, S., CLARK, J., FISHER, C., KELSEY, A., NOJIMA, T., SONOBE, H., COOPER, C. and GUSTERSON, B., Interphase fluorescence in situ hybridization and reverse transcription polymerase chain reaction as a diagnostic aid for synovial sarcoma. Amer. J. Pathol., 148, 559-567 (1996).
19. SHIPLEY, J.M., CLARK, J., CREW, A.J., BIRDSALL, S., ROQUES, P.J., GILL, S., CHELLY, J., MONACO, A.P., ABE, S., GUSTERSON, B.A. and COOPER, C.S., The t(X;18)(p11.2;q11.2) translocation found in synovial sarcomas involves two distinct loci on the X chromosome. Oncogene, 9, 1447-1453 (1994).
20. TEIXEIRA, M., QVIST, H., BOHLER, P., PANDIS, N. and HEIM, S., Cytogenetic analysis shows that carcinosarcomas of the breast are of monoclonal origin. Genes Chromosomes Cancer, 22, 145-151 (1998).
21. TSUJI, S., HISAOKA, M., HASHIMOTO, H., SHIMAJIRI, S., KOMIYA, S., USHIJIMA, M. and NAKAMURA, T., Detection of SYT-SSX fusion transcripts in synovial sarcoma by reverse transcription-polymerase chain reaction using archival paraffin embedded tissues. Amer. J. Pathol., 153, 1807-1812 (1998).