Renal handling of human apolipoprotein(a) and its fragments in the rat

American Journal of Kidney Diseases

Volumn 38, Issue 3, 2001, Pages 619-630

  Reblin, Tjark ^a,b   Donarski, Nicolette ^c   Fineder, Linda ^c   Brsen, Jan H ^c   Dieplinger, Hans ^c   Thaiss, Friedrich ^c   Stahl, Rolf A K ^c   Beisiegel, Ulrike ^c   Wolf, Gunter ^c  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF INNSBRUCK   (Austria)

^c NONE

Author keywords

Apolipoprotein (a) apo(a) ; Apolipoprotein B (apo B); Lipoprotein(a) Lp(a) ; Megalin; Wistar rat

Indexed keywords

APOLIPOPROTEIN A; APOLIPOPROTEIN B; LIPOPROTEIN A;

ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GLOMERULUS; HALF LIFE TIME; IMMUNOHISTOCHEMISTRY; KIDNEY METABOLISM; KIDNEY TUBULE; LIPID STORAGE; LIPOLYSIS; LIPOPROTEIN METABOLISM; MALE; NONHUMAN; PLASMA CLEARANCE; RAT; URINE LEVEL;

EID: 0034877816     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/ajkd.2001.26889     Document Type: Article

References (45)

1. Turnover of lipoprotein(a) in man
2. Changes of genetic apolipoprotein phenotypes caused by liver transplantation: Implications for apolipoprotein synthesis
3. Oleate stimulates the formation of triglyceride-rich particles containing apoB100-apo(a) in long-term primary cultures of human hepatocytes
4. Variation in lipoprotein(a) concentrations among individuals with the same apolipoprotein(a) isoform is determined by the rate of lipoprotein(a) production
5. The inverse association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform size is not due to differences in Lp(a) catabolism but to differences in production rate
6. Studies on the role of specific cell surface receptors in the removal of lipoprotein(a) in man
7. Heterogeneity of human lipoprotein Lp[a]: Cytochemical and biochemical studies on the interaction of two Lp[a] species with the LDL receptor
8. Malondialdehyde modification of lipoprotein(a) produces avid uptake by human monocyte-macrophages
9. Lp(a) lipoprotein enters cultured fibroblasts independently of the plasma membrane low density receptor
10. The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans
11. Heterogeneous lipoprotein (a) size isoforms differ by their interaction with the low density lipoprotein receptor and the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor
12. Interaction of a recombinant form of apolipoprotein(a) with human fibroblasts and with the human hepatoma cell line HepG2
13. Cellular uptake of lipoprotein(a) by mouse embryonic fibroblasts via the LDL receptor and the LDL receptor-related protein
14. Lp(a) lipoprotein in patients with chronic renal failure treated by hemodialysis
15. Elevated plasma concentrations of lipoprotein(a) in patients with end-stage renal disease are not related to the size polymorphism of apolipoprotein(a)
16. Elevated plasma lipoprotein(a) in patients with the nephrotic syndrome
17. Apolipoprotein(a) phenotype-associated decrease in lipoprotein(a) plasma concentrations after renal transplantation
18. Increased serum lipoprotein(a) levels in patients with early renal failure
19. Decreased urinary apolipoprotein(a) excretion in patients with impaired renal function
20. Evidence for increased synthesis of lipoprotein(a) in the nephrotic syndrome
21. Increased plasma concentrations of LDL-unbound apo(a) in patients with end-stage renal disease
22. Apolipoprotein(a) kringle 4-containing fragments in human urine: Relationship to plasma levels of lipoprotein(a)
23. Urinary excretion of apo(a) fragments: Role in apo(a) catabolism
24. High plasma levels of apo(a) fragments in Caucasians and African-Americans with end-stage renal disease: Implications for plasma Lp(a) assay
25. Kringle-containing fragments of apolipoprotein(a) circulate in human plasma and are excreted into the urine
26. Urinary apo(a) discriminates coronary artery disease patients from controls
27. Urinary excretion of apolipoprotein(a) fragments in type 1 diabetes mellitus patients
28. Polymorphonuclear cells isolated from human peripheral blood cleave lipoprotein(a) and apolipoprotein(a) at multiple interkringle sites via the enzyme elastase: Generation of mini-Lp(a) particles and apo(a) fragments
29. Renovascular arteriovenous differences in Lp(a) plasma concentrations suggest removal of Lp(a) from the renal circulation
30. Localization of apolipoprotein(a) and B-100 in various renal diseases
31. Interaction of native and oxidized lipoprotein(a) with human mesangial cells and matrix
32. Interaction of lipoprotein Lp(a) and low density lipoprotein with glycosaminoglycans from human aorta
33. Lipoprotein(a) binds to fibronectin and has serine proteinase activity capable of cleaving it
34. Interaction of Lp(a) with plasminogen binding sites on cells
35. Apolipoproteins and lipoprotein receptors in glomeruli in human kidney diseases
36. Abetalipoproteinemia with an ApoB-100-lipoprotein(a) glyco-protein complex in plasma
37. Genetic architecture of the atherogenic lipoprotein(a)
38. Correlation of apolipoprotein(a) isoproteins with Lp(a) density and distribution in fasting plasma
39. Molecular weight determination of protein dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system
40. Proteinblotting
41. Kringle 4 of human apolipoprotein (A) shares a linear antigenic site with human catalase
42. LDL-apheresis significantly reduces urinary apo(a) excretion
43. The Heymann nephritis antigenic complex: Megalin (gp330) and RAP
44. Identification of megalin/gp330 as a receptor for lipoprotein(a) in vitro
45. Structural and functional features of protein handling in the kidney proximal tubule