Urinary apo(a) discriminates coronary artery disease patients from controls

Atherosclerosis

Volumn 129, Issue 1, 1997, Pages 103-110

  Kostner, Karam M ^a   Huber, Kurt ^a   Stefenelli, Thomas ^a   Rinner, Heinrich ^b   Maurer, Gerald ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

atherosclerosis; plasma Lp(a); risk factor; ROC plot

Indexed keywords

LIPOPROTEIN A;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; HUMAN; IMMUNOASSAY; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; URINE LEVEL;

APOLIPOPROTEINS A; BLOTTING, WESTERN; CORONARY ANGIOGRAPHY; CORONARY DISEASE; CREATININE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HUMANS; IMMUNOASSAY; LIPOPROTEIN(A); MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; RISK FACTORS;

EID: 0031052470     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(96)06011-X     Document Type: Article

References (47)

1. Morrisett JD, Gaubath JW, Knapp RD, Guevara JG. Structural properties of apo(a): a major apoprotein of human lipoprotein(a). In: Scanu AM (ed). Lipoprotein(a), San Diego, NY: Academic Press, 1990;53-74.
2. Mc Lean JW, Tomlinson JE, Kuang WJ, Eaton DL, Chen EY, Fless GM, Scanu AM, Lawn RM. cDNA sequence of human apolipoprotein(a) in homologous to plasminogen. Nature 1987;330:132-137.
3. Utermann G, Menzel HJ, Kraft HG, Duba HC, Kemmler HG, Seitz C. Lp(a) glycoprotein phenotypes: inheritance and relation to Lp(a)-lipoprotein. J Clin Invest 1987;80:458-465.
4. Lackner C, Boerwinkle E, Leffert CC, Rahnig T, Hobbs HH. Molecular basis of apolipoprotein(a) isoform heterogeneity as resolved by pulsed-field gel electrophoresis. J Clin Invest 1991;87:2153-2161.
5. Boerwinkle E, Leffert CC, Lin J, Lackner C, Chiesa G, Hobbs HH. Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J Clin Invest 1992;90:52-60.
6. Smith EB, Cochran S. Factors influencing the accumulation in fibrous plaques of lipid, derived from low-density lipoproteins: preferential immobilisation of Lp(a). Atherosclerosis 1990;84:173-181.
7. Graininger DJ, Kirchenloke HL, Metcalfe JC, Weissberg PL, Wade DP, Lawn RM. Proliferation of human smooth muscle cells promoted by Lp(a). Science 1993;260:1655-1658.
8. Bihari-Vaga M, Gruber R, Rotheneder M, Zechner R, Kostner GM. Interaction of Lp(a) and LDL with glycosamino glycans and proteoglycans from human aorta. Arteriosclerosis 1988;8:851-857
9. Salonen EM, Jauhiainen M, Zardil F, Vohevi A, Ehnholm C. Lp(a) binds to fibronectin and has serine protease activity, capable of cleaving it. EMBO J 1984;8:4035-4040.
10. Bottalico LA, Keesla GA, Fless GM, Tobas I. Chosesterol loading of macrophages leads to marked enhancement of native Lp(a) and apo(a) internalization and degradation. J Biol Chem 1993;268:8569-8573.
11. Miles LA, Plow EF. Lp(a): an interloper into the fibrinolytic system? Thromb and Haemostasis 1990;63(3):331-335.
12. Kostner GM, Avogaro P, Cazzolato G, Marth E, Bittolo Bon G. Lipoprotein (Lp(a)) and the risk for myocardial infarction. Atherosclerosis 1981;38:51-61.
13. Haynes RB. How to read clinical journals II: to learn about a diagnostic test. CMA J. 1981;124:703-710.
14. Armstrong VW, Cremer P, Eberle E, Manke A, Schulze F, Wieland H, Kreuzer H, Seidel D. The association between serum Lp(a) concentrations and angiographically assessed coronary atherosclerosis. Atherosclerosis 1986;62:249-257.
15. Rhoads GG, Dahlen G, Berg K, Morton NE, Dannenberg, AL. Lp(a) lipoprotein as a risk factor for myocardial infarction. JAMA 1986;256:2540-2544.
16. Sandholzer C, Saha N, Kark JD, Ress A, Jaross W, Dieplinger H, Hoppichler F, Boerwinkle E, Utermann G. Apo(a) isoforms predict risk for coronary heart disease. Arterioscler Thromb 1992;12:1214-1226.
17. Marquez A, Mendoza S, Carrasco H, Hamer T, Glueck CJ. High lipoprotein(a) in children from kindreds with parental premature myocardial infarction. Pediatr Res 1993;34:670-674.
18. Schaefer EJ, Lamon-Fava S, Jenner JL, McNamara JR, Ordovas JM, Davis E, Abolafia JM, Lippel K, Levy RI. Lipoprotein(a) levels and risk of coronary heart disease in men. JAMA 1994;271:999-1003.
19. Gotoh T, Kuroda T, Yamasawa M, Nishinaga M, Mitsuhashi T, Seino Y, Nagoh N, Kayaba K, Yamada S, Matsuo H, Hosoe M, Itoh Y, Kawai T, Igarashi M, Shimada K. Correlation between lipoprotein(a) and aortic valve sclerosis assessed by echocardiography (the JMS cardiac echo and cohort study). Am J Cardiol 1995;76:928-932.
20. Zenker G, Költringer P, Boné G, Niederkorn K, Pfeiffer K, Jürgens G. Lipoprotein(a) as a strong indicator for cerebrovascular disease. Stroke 1986;17:942-945.
21. Ridker PM, Hennekens CH, Stampfer MJ. A prospective study of lipoprotein(a) and the risk of myocardial infarction. JAMA 1993;270:2195-2199.
22. Cremer P, Nagel D, Labrot B, Mann H, Muche R, Elster H, Seidel D. Lipoprotein Lp(a) as predictor of myocardial infarction in comparison to fibrinogen, LDL cholesterol and other risk factors: results from the prospective göttingen risk incidence and prevalence study (GRIPS). Eur J Clin Invest 1994;24:444-453.
23. Alfthan G, Pekkanen J, Jauhiainen M, Pitkäniemi J, Karvonen M, Tuomilehto J, Salonen JT, Ehnholm C. Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study. Atherosclerosis 1994;106:9-19.
24. Moliterno DJ, Jokinen EV, Miserez AR, Lange RA, Willard JE, Boerwinkle E, Hillis D, Hobbs HH. No association between plasma lipoprotein(a) concentrations and the presence or absence of coronary atherosclerosis in African-Americans. Arterioscler Thromb Vasc Biol 1995;15:850-855.
25. Mooser V, Seabra MC, Abedin M, Landschulz KT, Marcovina S, Hobbs HH. Apolipoprotein(a) kringle 4-containing fragments in human urine. J Clin Invest 1996;97:858-864.
26. Frank S, Krasznai K, Durovic S, Lobentanz E-M, Dieplinger H, Wagner E, Zatloukal K, Cotten M, Utermann G, Kostner GM, Zechner R. High level expression of various apolipoprotein(a) isoforms by 'transferrinfection': the role of kringle-IV sequences in the extracellular association with low density lipoprotein. Biochemistry 1994;33:12329-12339.
27. Frank S, Durovic S, Kostner GM. Structural requirements of Apo(a) for the Lp(a) assembly. Biochem J 1994;304:27-30.
28. Dieplinger HD, Gruber G, Krasznai K, Reschauer S, Seidel C, Burns G, Müller HJ, Csaszar A, Vogel W, Robenek H, Utermann G. Kringle 4 of human apolipoprotein (a) shares a linear antigenic site with human catalase. J Lipid Res 1995;36:813-822.
29. Steyrer E, Durovic S, Frank S, Gießauf W, Burger A, Dieplinger H, Zechner R, Kostner GM. The role of lecithin: cholesterol acyltransferase for lipoprotein(a) assembly. Structural integrity of low density lipoproteins is a prerequisite for Lp(a) formation in human plasma. J Clin Invest 1994;94:2330-2340.
30. Beck JR, Schultz EK. The use of relative operating characteristic (ROC) curves in test performance evaluation. Arch Pathol Lab Med 1986;110:13-20.
31. Zweig MH, Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 1993;39:561-577.
32. White AL, Rainwater DL, Lanford RF. Intracellular maturation of apoprotein(a) and assembly of lipoprotein(a) in primary baboon hepatocytes. J Lipid Res 1993;34:509-517.
33. Ernst A, Helmhold M, Brunner C, Pethö-Schramm A, Armstrong WV, Müller HJ. Indentification of two functionally distinct lysine-binding sites in kringle 37 and kringle 32-37 of human apolipoprotein(a). J Biol Chem 1995;270:6227-6234.
34. Linton MF, Farese RV Jr, Chiesa G, Gross DS, Chin P, Hammer RE, Hobbs HH, Young SG. Transgenic mice expressing high plasma concentration of human apolipoprotein B-100 and lipoprotein(a). J Clin Invest 1993;92:3029-3037.
35. White AL, Hixon JE, Rainwater DL, Lanford RE. Molecular basis for 'null' lipoprotein(a) phenotypes and the influence of apolipoprotein(a) size on plasma lipoprotein(a) level in the baboon. J Biol Chem 1994;269:9060-9066.
36. White AL, Lanford RE. Cell surface assembly of lipoprotein(a) in primary cultures of baboon hepatocytes. J Biol Chem 1994;269:28 716-28 723.
37. Trieu VN, McConathy WJ. A two-step model for lipoprotein(a) formation. J Biol Chem 1995;270:15 471-15 474.
38. Armstrong VW, Harrach B, Robenek H, Helmhold M, Walli AK, Seidel D. Heterogenity of human lipoprotein Lp(a): cytochemical and biochemical studies on the interaction of two Lp(a) species with the LDL receptor. J Lipid Res 1990;31:429-441.
39. Steyrer E, Kostner GM. The interaction of lipoprotein Lp(a) with the B/E receptor. J Lipid Res 1990;31:1247-1253.
40. Krempler F, Kostner GM, Roscher A, Sandhofer F. Studies on the role of specific cell surface receptors on the removal of Lp(a) in man. J Clin Invest 1983;71:1431-1441.
41. Kostner GM, Gavish D, Leopold B, Bolzano K, Weintraub MS, Breslow JL. HMG CoA reductase inhibitors lower LDL cholesterol without reducing Lp(a) levels. Circulation 1989;80:1313-1319.
42. Kostner GM, Grillhofer H. Lipoprotein(a) mediates high affinity low density lipoprotein association to receptor negative fibroblasts. J Biol Chem 1991;266:21 287-21 292.
43. Kostner GM. Interaction of Lp(a) and of apo(a) with liver cells. Arterioscler Thromb 1993;13:1101-1109.
44. Liu R, Saku K, Kostner GM, Hirata K, Zhang B, Shiom M, Arakawa K. In vivo kinetics of lipoprotein(a) in homozygous Watanabe heritable hyperlipidaemic rabbits. Eur J Clin Invest 1993;23:561-565.
45. Hofman SL, Eaton DL, Brown MS, McConnathy WJ, Goldstein JL, Hammer RE. Overexpression of human LDL-receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice. J Clin Invest 1990;85:1542-1547.
46. Kostner GM. The physiological role of Lp(a) In: Scanu AM (ed). Lipoprotein(a). Inc. Harcourt Brace Javanovich, Academic Press, Publishers 1990;183-204.
47. Oida K, Takai H, Maeda H, Takahashi S, Shimada A, Suzuki J, Tamai T, Nakai T, Miyabo S. Apolipoprotein(a) is present in urine and its excretion is decreased in patients with renal failure. Clin Chem 1992;38/11:2244-2248.