Effects of ecstasy (MDMA) on the brain in abstinent users: Initial observations with diffusion and perfusion MR imaging

Radiology

Volumn 220, Issue 3, 2001, Pages 611-617

  Reneman, L ^a   Majoie, C B L M ^a   Habraken, J B A ^a   Den Heeten, G J ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

14.12144; Abuse; Brain; Diffusion study; Drugs; Effects of drugs on; Magnetic resonance (MR); Perfusion study

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE;

ARTICLE; BRAIN MAPPING; BRAIN SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DIFFUSION COEFFICIENT; GLOBUS PALLIDUS; HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

EID: 0034875966     PISSN: 00338419     EISSN: None     Source Type: Journal    
DOI: 10.1148/radiol.2202001602     Document Type: Article

References (52)

1. Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine
2. The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain
3. 3,4-methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: Quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites
4. (+/-)3,4-Methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates
5. Lasting effects of (+-)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: Neurochemical observations
6. Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: Immunocytochemical evidence for neurotoxicity
7. Distinct morphologic classes of serotonergic axons in primates exhibit differential vulnerability to the psychotropic drug 3,4-methylenedioxymethamphetamine
8. Positron emission tomographic evidence of toxic effect of MDMA ("ecstasy") on brain serotonin neurons in human beings
9. Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA ('ecstasy') users
10. In vivo detection of short- and long-term MDMA neurotoxicity: A positron emission tomography study in the living baboon brain
11. MDMA (ecstasy) neurotoxicity: Assessing and communicating the risks
12. Serotonin in the regulation of brain microcirculation
13. 5-HT receptors in human and animal cerebrovasculature
14. Death after ecstasy ingestion: Neuropathological findings
15. A pure amnestic syndrome after MDMA ("ecstasy") ingestion
16. Subarachnoid haemorrhage associated with MDMA abuse
17. Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")
18. Ecstasy and the dance of death
19. Diffusion MR imaging: Clinical applications
20. Diffusion-weighted MR imaging of acute stroke: Correlation with T2-weighted and magnetic susceptibility-enhanced MR imaging in cats
21. Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI
22. Diffusion MRI: Precision, accuracy and flow effects
23. Diffusion tensor MR imaging of the human brain
24. Water diffusion and acute stroke
25. Diffusion magnetic resonance imaging in multiple sclerosis
26. In vivo magnetic resonance diffusion measurement in the brain of patients with multiple sclerosis
27. Apparent diffusion coefficient on rat brain and nerves intoxicated with methylmercury
28. Perfusion imaging by nuclear magnetic resonance
29. High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. I. Mathematical approach and statistical analysis
30. Cerebral blood volume maps of gliomas: Comparison with tumor grade and histologic findings
31. Echo-planar MR cerebral blood volume mapping of gliomas: Clinical utility
32. Fast magnetic resonance diffusion-weighted imaging of acute human stroke
33. Determinants of anisotropic water diffusion in nerves
34. Neurotoxicity of MDMA and related compounds: Anatomic studies
35. Altered serotonin innervation patterns in the forebrain of monkeys treated with (+/-)3,4-methylenedioxymethamphetamine seven years previously: Factors influencing abnormal recovery
36. Increased water self-diffusion in chronic plaques and in apparently normal white matter in patients with multiple sclerosis
37. Demyelinating plaques in relapsing-remitting and secondary-progressive multiple sclerosis: Assessment with diffusion MR imaging
38. Assessment of cerebrovascular reactivity by dynamic susceptibility contrast-enhanced MR imaging
39. Magnetic resonance imaging assessment of cerebral hemodynamics during spreading depression in rats
40. Cocaine decreases relative cerebral blood volume in humans: A dynamic susceptibility contrast magnetic resonance imaging study
41. Cerebrovascular and functional consequences of 5-HT1A receptor activation
42. MDMA-induced neurotoxicity: Parameters of degeneration and recovery of brain serotonin neurons
43. Serotonergic recovery after (+/-)3,4-(methylenedioxy) methamphetamine injury: Observations in rats
44. Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. I. Synaptosomal uptake and tissue concentrations
45. Serotonin neurotoxicity after (+/-)3,4-methylenedioxymethamphetamine (MDMA; "ecstasy"): A controlled study in humans
46. Mono-amine metabolites in the cerebrospinal fluid of recreational users of 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy")
47. 5-hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of non-human primates
48. MDMA ("ecstasy") and its association with cerebrovascular accidents: Preliminary findings
49. Effect of ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] on cerebral blood flow: A co-registered SPECT and MRI study
50. MR diffusion imaging of cerebral infarction in humans