Excretion into gastrointestinal tract of irinotecan lactone and carboxylate forms and their pharmacodynamics in rodents

Pharmaceutical Research

Volumn 18, Issue 6, 2001, Pages 814-822

  Arimori, Kazuhiko ^a   Kuroki, Noriaki ^b   Kumamoto, Ayumi ^b   Tanoue, Naomi ^b   Nakano, Masahiro ^b   Kumazawa, Eiji ^c   Tohgo, Akiko ^c   Kikuchi, Masahiko ^c  

^a UNIVERSITY OF MIYAZAKI   (Japan)

^b KUMAMOTO UNIVERSITY HOSPITAL   (Japan)

^c DAIICHI SANKYO CO   (Japan)

Author keywords

Antitumor activity; Carboxylate; Irinotecan; Lactone; Pharmacokinetics

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; CARBOXYLIC ACID DERIVATIVE; DRUG METABOLITE; IRINOTECAN; LACTONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIARRHEA; DRUG ABSORPTION; DRUG ELIMINATION; DRUG EXCRETION; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR VOLUME;

ANIMALS; CAMPTOTHECIN; DIARRHEA; DIGESTIVE SYSTEM; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; INCIDENCE; MALE; MICE; MICE, INBRED BALB C; RATS; RATS, WISTAR; SARCOMA, EXPERIMENTAL; TISSUE DISTRIBUTION;

EID: 0034872427     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011040529881     Document Type: Article

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