Asymmetric distribution of phosphatidylcholine and sphingomyelin between micellar and vesicular phases': Potential implications for canalicular bile formation

Journal of Lipid Research

Volumn 40, Issue 11, 1999, Pages 2022-2033

  Eckhardt, Erik R M ^a   Moschetta, Antonio ^a   Renooij, Willem ^a   Goerdayal, Soenita S ^a   Van Berge Henegouwen, Gerard P ^a   Van Erpecum, Karel J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Bile sails; Canalicular membrane; Cholesterol; Differential scanning calorimetry; Intermixed micellar vesicular bile salt concentration; Micelles; Phosphatidylcholine; Phospholipids; Quasi elastic light scattering spectroscopy; Sphingomyelin; Vesicles

Indexed keywords

BILE SALT; CHOLESTEROL; DETERGENT; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; SATURATED FATTY ACID; SPHINGOMYELIN; TAUROCHOLIC ACID;

ARTICLE; BILE SECRETION; EGG YOLK; INTRAHEPATIC BILE DUCT; LIPID COMPOSITION; MICELLE; PHASE TRANSITION; PHOSPHOLIPID SYNTHESIS; PHOSPHOLIPID VESICLE; PRIORITY JOURNAL; SOLUBILIZATION; SUPERNATANT; ULTRACENTRIFUGATION; ULTRAFILTRATION;

ANIMALS; BILE ACIDS AND SALTS; BILE CANALICULI; CALORIMETRY, DIFFERENTIAL SCANNING; CHOLESTEROL; EGG YOLK; GELS; LIPOSOMES; MICELLES; MILK; MODELS, MOLECULAR; PHOSPHATIDYLCHOLINES; SPHINGOMYELINS; TAUROCHOLIC ACID; TEMPERATURE; THERMODYNAMICS;

EID: 0032719116     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Schachter, D. 1988. The hepatocyte plasma membrane: organization and differentiation. In The Liver: Biology and Pathobiology. I. M. Arias, W. B. Jakoby, H. Popper, D. Schachter, and D. A. Shafritz, editors. Raven Press, Ltd., New York, NY. 131-140.
2. Smit, J. J., A. H. Schinkel, R. P. J. Oude Elferink, A. K. Groen, E. Wagenaar, I., van Deemter, C. A. Mol, R. Ottenhoff, N. M. van der Lugt, and M. A. van Roon. 1993. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell. 75: 451-462.
3. Gerloff, T., B. Stieger, B. Hagenbuch, J. Madon, L. Landmann, J. Roth, A. F. Hofmann, and P. J. Meier. 1998. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J. Biol. Chem. 273: 10046-10050.
4. Crawford, J. M., G. M. Mockel, A. R. Crawford, S. J. Hagen, V. C. Hatch, S. Barnes, J. J. Godleski, and M. C. Carey. 1995. Imaging biliary lipid secretion in the rat: ultrastructural evidence for vesiculation of the hepatocyte canalicular membrane. J. Lipid Res. 36: 2147-2163.
5. Higgins, J. A., and W. H. Evans. 1978. Transverse organization of phospholipids across the bilayer of plasma membrane subfractions of rat hepatocytes. Biochem. J. 174: 563-567.
6. Alvaro, D., A. Cantafora, A. F. Attili, C. S. Ginanni, C. De Luca, G. Minervini, A. Di Biase, and M. Angelico. 1986. Relationships between bile salts hydrophilicity and phospholipid composition in bile of various animal species. Comp. Biochem. Physiol. [B.]. 83: 551-554.
7. Hay, D. W., M. J. Cahalane, N. Timofeyeva, and M. C. Carey. 1993. Molecular species of lecithins in human gallbladder bile. J. Lipid Res. 34: 759-768.
8. Nibbering, C. P., and M. C. Carey. 1999. Sphingomyelins of rat liver: biliary enrichment with molecular species containing 16:0 fatty acids as compared to canalicular-enriched plasma membranes. J. Membr. Biol. 167: 165-171.
9. van Hoeven, R. P., P. Emmelot, J. H. Krol, and E. P. M. Oomen-Meulemans. 1975. Studies on plasma membranes. XXII. Fatty acid profiles of lipid classes in plasma membranes of rat and mouse livers and hepatomas. Biochim. Biophys. Acta. 380: 1-11.
10. Kremmer, T., M. H. Wisher, and W. H. Evans. 1976. The lipid composition of plasma membrane subfractions originating from the three major functional domains of the rat hepatocyte cell surface. Biochim. Biophys. Acta. 455: 655-664.
11. Lund-Katz, S., H. M. Laboda, L. R. McLean, and M. C. Phillips. 1988. Influence of molecular packing and phospholipid type on rates of cholesterol exchange. Biochemistry. 27: 3416-3423.
12. Lange, Y., J. S. D'Alessandro, and D. M. Small. 1979. The affinity of cholesterol for phosphatidylcholine and sphingomyelin. Biochim. Biophys. Acta. 556: 388-398.
13. Slotte, J. P. 1992. Enzyme-catalyzed oxidation of cholesterol in mixed phospholipid monolayers reveals the stoichiometry at which free cholesterol clusters disappear. Biochemistry. 31: 5472-5477.
14. Demel, R. A., J. W. C. M. Jansen, P. W. M. Van Dijck, and L. L. M. Van Deenen. 1977. The preferential interaction of cholesterol with different classes of phospholipids. Biochim. Biophys. Acta. 465: 1-10.
15. Bar, L. K., Y. Barenholz, and T. E. Thompson. 1987. Dependence on phospholipid composition of the fraction of cholesterol undergoing spontaneous exchange between small unilamellar vesicles. Biochemistry. 26: 5460-5465.
16. Yeagle, P. L., and J. E. Young. 1986. Factors contributing to the distribution of cholesterol among phospholipid vesicles. J. Biol. Chem. 261: 8175-8181.
17. Fugler, L., S. Clejan, and R. Bittman. 1985. Movement of cholesterol between vesicles prepared with different phospholipids or sizes. J. Biol. Chem. 260: 4098-4102.
18. Mattjus, P., R. Bittman, C. Vilcheze, and J. P. Slotte. 1995. Lateral domain formation in cholesterol/phospholipid monolayers as affected by the sterol side chain conformation. Biochim. Biophys. Acta. 1240: 237-247.
19. Hakomori, S. 1983. Chemistry of Glycosphingolipids. In Handbook of Lipid Research. D. J. Hanahan, editor. Plenum Press, New York. 37-39.
20. van Erpecum, K. J., and M. C. Carey. 1997. Influence of bile salts on molecular interactions between sphingomyelin and cholesterol: relevance to bile formation and stability. Biochim. Biophys. Acta. 1345: 269-282.
21. Renooij, W., P. J. van Gaal, K. J. van Erpecum, B. J. M. van de Heijning, and G. P. van Berge-Henegouwen. 1996. Quantifying vesicle/mixed micelle partitioning of phosphatidylcholine in model bile by using radiolabeled phosphatidylcholine species. J. Lab. Clin. Med. 128: 561-567.
22. Turley, S. D., and J. M. Dietschy. 1978. Reevaluation of the 3α-hydroxysteroid dehydrogenase assay for total bile acids in bile. J. Lipid Res. 19: 924-928.
23. Cohen, D. E., M. Angelico, and M. C. Carey. 1989. Quasielastic light scattering evidence for vesicular secretion of biliary lipids. Am. J. Physiol. 257: G1-G8.
24. Rouser, G., S. Fleischer, and A. Yamamoto. 1970. Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids. 5: 494-496.
25. Rossi, S. S., J. L. Converse, and A. F. Hofmann. 1987. High pressure liquid chromatographic analysis of conjugated bile acids in human bile: simultaneous resolution of sulfated and unsulfated litocholyl amidates and the common conjugated bile acids. J. Lipid Res. 28: 589-595.
26. Bligh, E. G., and W. J. Dyer. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37: 911-917.
27. Donovan, J. M., N. Timofeyeva, and M. C. Carey. 1991. Influence of total lipid concentration, bile salt:lecithin ratio, and cholesterol content on inter-mixed micellar/vesicular (non-lecithin-associated) bile salt concentrations in model bile. J. Lipid Res. 32: 1501-1512.
28. Donovan, J. M., and A. A. Jackson. 1993. Rapid determination by centrifugal ultrafiltration of inter-mixed micellar/vesicular (non-lecithin-associated) bile salt concentrations in model bile: influence of Donnan equilibrium effects. J. Lipid Res. 34: 1121-1129.
29. Eckhardt, E. R. M., B. J. M. van de Heijning, K. J. van Erpecum, W. Renooij, and G. P. vanBerge-Henegouwen. 1998. Quantitation of cholesterol-carrying particles in human gallbladder bile. J. Lipid Res. 39: 594-603.
30. Wang, D. Q. H., and M. C. Carey. 1996. Complete mapping of crystallization pathways during cholesterol precipitation from model bile: influence of physical-chemical variables of pathophysiologic relevance and identification of a stable liquid crystalline state in cold, dilute and hydrophilic bile salt-containing systems. J. Lipid Res. 37: 606-630.
31. Carey, M. C. 1988. Lipid solubilisation in bile. In Bile Acids in Health and Disease. T. C. Northfield, R. P. Jazrawi, and P. Zentler-Munro, editors. Kluwer Acad Publishers, London, 61-82.
32. Schroeder, R. J., E. London, and D. A. Brown. 1994. Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinoshol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior. Proc. Natl. Acad. Sci. USA. 91: 12130-12134.
33. Luk, A. S., E. W. Kaler, and S. P. Lee. 1997. Structural mechanisms of bile salt-induced growth of small unilamellar cholesterol-lecithin vesicles. Biochemistry. 36: 5633-5644.
34. Yousef, I. M., and M. M. Fisher. 1976. In vitro effect of free bile acids on the bile canalicular membrane phospholipids in the rat. Can. J. Biochem. 54: 1040-1046.
35. Gerloff, T., P. J. Meier, and B. Stieger. 1998. Taurocholate induces preferential release of phosphatidylcholine from rat liver canalicular vesicles. Liver. 18: 306-312.
36. Billington, D., R. Coleman, and Y. A. Lusak. 1977. Topographical dissection of sheep erythrocyte membrane phospholipids by taurocholale and glycocholate. Biochim. Biophys. Acta. 466: 526-530.
37. Cohen, D. E., and M. C. Carey. 1991. Acyl chain unsaturation modulates distribution of lecithin molecular species between mixed micelles and vesicles in model bile. Implications for particle structure and metastable cholesterol solubilities. J. Lipid Res. 32: 1291-1302.
38. Epand, R. M. 1998. Lipid polymorphism and protein-lipid interactions. Biochim. Biophys. Acta. 1376: 353-368.
39. Koynova, R., and M. Caffrey. 1995. Phases and phase transitions of the sphingolipids. Biochim. Biophys. Acta. 1255: 213-236.
40. Xiang, T. X., and B. D. Anderson. 1998. Phase structures of binary lipid bilayers as revealed by permeability of small molecules. Biochim. Biophys. Acta. 1370: 64-76.
41. Ahmed, S. N., D. A. Brown, and E. London. 1997. On the origin of Sphingolipid/Cholesterol-rich detergent-insoluble cell membranes: physiological concentrations of cholesterol and sphingolipid induce formation of a detergent-insoluble, liquid-ordered lipid phase in model membranes. Biochemistry. 36: 10944-10953.
42. Schroeder, R. J., S. N. Ahmed, Y. Zhu, E. London, and D. A. Brown. 1998. Cholesterol and sphingolipid enhance the triton X-100 insolubility of glycosylphosphatidylinositol-anchored proteins by promoting the formation of detergent-insoluble ordered membrane domains. J. Biol. Chem. 273: 1150-1157.
43. Donovan, J. M., A. A. Jackson, and M. C. Carey. 1993. Molecular species composition of inter-mixed micellar/vesicular bile salt concentrations in model bile: dependence upon hydrophilic-hydrophobic balance. J. Lipid Res. 34: 1131-1140.
44. Mazer, N. A., G. B. Benedek, and M. C. Carey. 1980. Quasielastic light-scattering studies of aqueous biliary lipid systems. Mixed micelle formation in bile salt-lecithin solutions. Biochemistry. 19:601-615.
45. Cohen, D. E., M. Angelico, and M. C. Carey. 1990. Structural alterations in lecithin-cholesterol vesicles following interactions with monomeric and micellar bile salts: physical-chemical basis for subselection of biliary lecithin species and aggregative states of biliary lipids during bile formation. J. Lipid Res. 31: 55-70.
46. Schubert, R., and K-H. Schmidt. 1988. Structural changes in vesicle membranes and mixed micelles of various lipid compositions after binding of different bile salts. Biochemistry. 27: 8787-8794.
47. McLean, L. R., and M. C. Phillips. 1984. Cholesterol transfer from small and large unilamellar vesicles. Biochim. Acta. 776: 21-26.
48. Phillips, M. C., W. J. Johnson, and G. H. Rothblat. 1987. Mechanisms and consequences of cellular cholesterol exchange and transfer. Biochim. Acta. 906: 223-275.
49. Simons, K., and G. van Meer. 1988. Lipid sorting in epithelial cells. Biochemistry. 27: 6197-6202.
50. Oude Elferink, R. P. J., R. Ottenhoff, M. van Wijland, C. M. Frijters, C. van Nieuwkerk, and A. K. Groen. 1996. Uncoupling of biliary phospholipid and cholesterol secretion in mice with reduced expression of mdr2 P-glycoprotein. J. Lipid Res. 37: 1065-1075.
51. Oude Elferink, R. P. J., G. N. J. Tytgat, and A. K. Groen. 1997. The role of mdr2 P-glycoprotein in hepatobiliary lipid transport. FASEB J. 11: 19-28.
52. Smith, A. J., J. M. de Vree, R. Ottenhoff, R. P. Oude Elferink, A. H. Schinkel, and P. Borst. 1998. Hepatocyte-specific expression of the human MDR3 P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent in Mdr2 (-/-) mice. Hepatology. 28: 530-536.