Altered plasma and brain disposition and pharmacodynamics of methadone in abstinent rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 288, Issue 1, 1999, Pages 179-187

  Garrido, María J ^a   Valle, Marta ^a   Calvo, Rosario ^a   Trocóniz, Iñaki F ^b  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

METHADONE; MORPHINE DERIVATIVE;

ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BOLUS INJECTION; BRAIN; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG CLEARANCE; DRUG DISPOSITION; HOSTILITY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT; TAIL FLICK TEST; TISSUE DISTRIBUTION;

EID: 0032961540     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Adams JU and Holtzman SG (1990) Tolerance and dependence after continuous morphine infusion from osmotic pumps measured by operant responding in rats. Psychopharmacology 100:451-458.
2. Beal SL and Sheiner LB (1992) NONMEM Users Guides. NONMEM Project Group. University of California, San Francisco, CA.
3. Bhargava H and Gulati A (1990) Down-regulation of brain and spinal cord μ-opiate receptors in morphine tolerant-dependents rats. Eur J Pharmacol 190:21-26.
4. Bhargava HN, Villar VM, Rahmani NH and Larsen AK (1992) Studies on the possible role of pharmacokinetics in the development of tolerance to morphine in rat. Gen Pharmacol 23:1199-1204.
5. Bläsig J, Herz A, Reinhold K, Zieglgansberger S (1973) Development of physical dependence on morphine in respect to time and dosage and quantification of the precipited withdrawal syndrome in rats. Physhopharmacology 33:19-38.
6. Boeckmann AJ, Sheiner LB and Beal SL (1992) NONMEM Users Guides-Part V. NONMEM Project Group. University of California, San Francisco, CA.
7. Brase DA (1986) Unequal opiate cross-tolerance to morphine in the locomotor-activation model in the mouse. Neuropharmacology 25:297-304.
8. Chen HSG and Gross JF (1979) Estimation of tissue-to-plasma partition coefficients used in physiological pharmacokinetic models. J Pharmacokin Biopharm 7:117-125.
9. Craft RM and Dykstra LA (1990) Differential cross-tolerance to opioids in squirrel monkeys responding under a shock titration schedule. J Pharmacol Exp Ther 252:945-952.
10. D'Amour FE and Smith DL (1941) A method for determining loss of pain sensation. J Pharmacol Exp Ther 72:74-79.
11. Dhawan BN, Cesselin F, Raghubir R, Reisine T, Bradley PB, Portoghese PS and Hamon M (1996) International union of pharmacology. XII. Classification of opioid receptors. Pharmacol Rev 48:567-592.
12. Dfaz A, Ruiz F, Flórez J, Hurlé MA and Pazos A (1995) μ-opioid receptor regulation during opioid tolerance and supersensitivity in rat central nervous system. J Pharmacol Exp Ther 274:1545-1551.
13. Ekblom M, Hammarlund-Udenaes M and Paalzow L (1993) Tolerance development and rebound effects of morphine in relation to different administrations in rats. J Pharmacol Exp Ther 266:244-252.
14. Gårdmark M, Ekblom M, Bouw R and Hammarlund-Udenaes M (1993) Quantification of effect delay and acute tolerance development to morphine in the rat. J Pharmacol Exp Ther 267:1061-1067.
15. Garrido M. J, Jiménez R, Gómez E and Calvo R (1996) Influence of plasma protein binding on analgesic effect on methadone in rats with spontaneous withdrawal. J Pharm Pharmacol 48:281-284.
16. Gómez E, Martínez-Jordá R, Suárez E, Garrido MJ and Calvo R (1995) Altered methadone analgesia due to changes in plasma protein binding: Role of the route of administration. Gen Pharmacol 26:1273-1276.
17. Goode PG (1971) An implanted reservoir of morphine solution for rapid induction of physical dependence in rats. Br J Pharmacol 41:558-566.
18. Grabrielsson JL, Johansson P, Bondesson U and Paalzow LK (1985) Analysis of methadone disposition in the pregnant rat by means of a physiological flow model. J Pharmacokinet Biopharm 13:355-372.
19. Inturrisi CE, Colburn WA, Kaiko RF, Houde RW and Foley KM (1987) Pharmacokinetic and pharmacodynamics of methadone in patients with chronic pain. Clin Pharmacol Ther 41:392-401.
20. Kissin I, Brown PT, Robinson A and Bradley E L (1991) Acute tolerance in morphine analgesia: Continuous infusion and single injection in rats. Anesthesiology 74: 166-171.
21. Kramer TH, Bartosz-Bechowski H, Davis P, Hruby VJ and Porreca F (1997) Extraordinary potency of a novel delta opioid receptor agonist is due in part to increased efficacy. Life Sci 61:129-135.
22. Kristiensen K, Blemmer T, Angelo HR, Christrup LL, Drenk NE, Rasmussen SN and Sjogren P (1996) Stereoselective pharmacokinetics of methadone in chronic pain patients. Ther Drug Monitor 18:221-227.
23. Ling GSF, Umans JG and Inturrisi CE (1981) Methadone: Radioimmunoassay and pharmacokinetics in the rat. J Pharmacol Exp Ther 217:147-151.
24. Liu SJ, Roerig DL and Wang RIH (1983) Brain and plasma levels of methadone and their relationship to analgesic activity of methadone in rats. Drug Metab Dispos 11:335-338.
25. Magnan J, Paterson SJ, Tavani A and Kosterlitz HW (1982) The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties. Naunyn Schmiedebergs Arch Pharmacol 319:197-205.
26. Mandema JM and Wada DR (1995) Pharmacodynamic model for acute tolerance development to the electroencephalographic effects of alfentanil in the rat. J Pharmacol Exp Ther 275:1185-1194.
27. Marathe PH, Shen DD, Artru AA and Bowdle A (1991) Effect of serum protein binding on the entry of lidocaine into brain and cerebrospinal fluid in dogs. Anesthesiology 75:804-812.
28. March C and Blanke RV (1985) Determination of free valproic acid concentrations using the Amicon Micropartition MPS-1 ultrafiltration system. Ther Drug Monitor 7:115-120.
29. Ohtani M, Kotaki H, Sawada Y and Iga T (1994) Comparative analysis of buprenorphine and norbuprenorphine induced analgesic effects based on pharmacokinetic-pharmacodynamic modelling. J Pharmacol Exp Ther 272:505-510.
30. Oullet DM-C and Pollack GM (1995) A pharmacokinetic-pharmacodynamic model of tolerance to morphine analgesia during infusion in rats. J Pharmacokin Biopharm 23:531-549.
31. Ouellet DM-C and Pollack GM (1997). Pharmacodynamics and tolerance development during multiple intravenous bolus morphine administration in rats. J Pharmacol Exp Ther 287:713-720.
32. Paronis CA and Holtzman SG (1992) Development of tolerance to the analgesic activity of μ-agonists after continuous infusion of morphine, meperidine or fentanyl in rats. J Pharmacol Exp Ther 262:1-9.
33. Pierce TL, Hope W and Raper C (1996) The induction and quantitation of methadone dependence in the rat. J Pharmacol Toxicol Meth 36:137-146.
34. Quin M, Nilsson M and Oie S (1994) Decreased elimination of drug in the presence of α1-acid glycoprotein is related to a reduced hepatocyte uptake. J Pharmacol Exp Ther 269:1176-1181.
35. Rowland M and Tozer TN (1995a) Physiologic concepts and kinetics: Distribution, in Clinical Pharmacokinetics. Concepts and applications, 3rd ed. (Rowland M and Tozer TN eds) pp 137-155, William & Wilkins, Media, PA.
36. Rowland M and Tozer TN (1995b) Physiologic concepts and kinetics: Distribution, in Clinical Pharmacokinetics. Concepts and applications, 3rd ed. (Rowland M and Tozer TN eds) pp 156-183, William & Wilkins, Media, PA.
37. Sheiner LB, Stanski DR, Vozeh S, Miller RD and Ham J (1979) Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocuranine. Clin Pharmacol Ther 25:358-371.
38. Thaw PA and Albutt EC (1980) A critical evaluation of a serum seromucoid assay and its replacement by a serum α1-glycoprotein assay. Ann Clin Biochem 17:140-143.
39. 2-adrenoceptor and μ-opioid receptor densities during morphine dependence and spontaneous withdrawal in rats. Naunyn Schmiedebergs Arch Pharmacol 336: 530-537.
40. Verotta D and Sheiner LB (1987) Simultaneous modeling of pharmacokinetics and pharmacodynamics: An improved algorithm. Comput Appl Biosc (CABIOS) 3:345-349.
41. Vozeh S, Schmidlin O and Taeschner W (1989) Pharmacokinetic drug data, in Drug data handbook (Clinical Pharmacokinetics ed) pp 1-38, ADIS Press Limited, Auckland.
42. Wolff K, Sanderson M, Hay AWM and Raistrick D (1991) Methadone concentrations in plasma and their relationship to drug dosage. Clin Chem 37:205-209.