Distinct differences in association of MHC class I with endoplasmic reticulum proteins in wild-type, and β2-microglobulin- and TAP-deficient cell lines

International Immunology

Volumn 13, Issue 8, 2001, Pages 1063-1073

  Paulsson, Kajsa M ^a   Wang, Ping ^a,b   Anderson, Per O ^a   Chen, Shangwu ^a   Pettersson, Ralf F ^c   Li, Suling ^a,d  

^a LUND UNIVERSITY   (Sweden)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^d BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

Assembly; Chaperones; MHC class I; 2 microglobulin

Indexed keywords

ANTIBODY; BETA 2 MICROGLOBULIN; BINDING PROTEIN; CALNEXIN; CALRETICULIN; CHAPERONE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; TAPASIN;

ARTICLE; CELL LINE; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION FUNCTION; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; KINETICS; MODEL; PRECIPITATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN STABILITY; STAGING;

EID: 0034864986     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/13.8.1063     Document Type: Article

References (55)

1. Generation, translocation, and presentation of MHC class I-restricted peptides
2. Structure, function, and diversity of class I major histocompatibility complex molecules
3. Class I MHC molecules: Assembly and antigen presentation
4. Folding and assembly of major histocompatibility complex class I heterodimers in the endoplasmic reticulum of intact cells precedes the binding of peptide
5. Assembly and maturation of HLA-A and HLA-B antigens in vivo
6. Cloning and functional characterization of a subunit of the transporter associated with antigen processing
7. Role of beta 2-microglobulin in the intracellular transport and surface expression of murine class I histocompatibility molecules
8. Peptide-bound major histocompatibility complex class I molecules associate with tapasin before dissociation from transporter associated with antigen processing
9. b-specific peptides to TAP and major histocompatibility complex class I in microsomes from wild-type, TAP1, and beta2-microglobulin mutant mice
10. Association of class I major histocompatibility heavy and light chains induced by viral peptides
11. Empty MHC class I molecules come out in the cold
12. Defective presentation of endogenous antigen by a cell line expressing class I molecules
13. Peptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains
14. Calnexin: A membrane-bound chaperone of the endoplasmic reticulum
15. The molecular chaperone calnexin facilitates folding and assembly of class I histocompatibility molecules
16. Chaperone selection during glycoprotein translocation into the endoplasmic reticulum
17. Functional relationship between calreticulin, calnexin, and the endoplasmic reticulum luminal domain of calnexin
18. A role for calnexin in the assembly of the MHC class I loading complex in the endoplasmic reticulum
19. Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP
20. Participation of a novel 88-kDa protein in the biogenesis of murine class I histocompatibility molecules
21. An unstable beta 2-microglobulin:major histocompatibility complex class I heavy chain intermediate dissociates from calnexin and then is stabilized by binding peptide
22. Species-specific differences in chaperone interaction of human and mouse major histocompatibility complex class I molecules
23. Calreticulin and calnexin interact with different protein and glycan determinants during the assembly of MHC class I
24. MHC class I/beta 2-microglobulin complexes associate with TAP transporters before peptide binding
25. Interaction with newly synthesized and retained proteins in the endoplasmic reticulum suggests a chaperone function for human integral membrane protein IP90 (calnexin)
26. Interaction of MHC class I molecules with the transporter associated with antigen processing
27. Tapasin is required for efficient peptide binding to transporter associated with antigen processing
28. Association of folding intermediates of glycoproteins with calnexin during protein maturation
29. Retention of unassembled components of integral membrane proteins by calnexin
30. Calnexin discriminates between protein conformational states and functions as a molecular chaperone in vitro
31. Conformation-independent binding of monoglucosylated ribonuclease B to calnexin
32. N-linked oligosaccharides are necessary and sufficient for association of glycosylated forms of bovine RNase with calnexin and calreticulin
33. Glucose trimming and reglucosylation determine glycoprotein association with calnexin in the endoplasmic reticulum
34. How N-linked oligosaccharides affect glycoprotein folding in the endoplasmic reticulum
35. Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality control
36. Identification of the region on the class I histocompatibility molecule that interacts with the molecular chaperone, p88 (calnexin, IP90)
37. Regulation of MHC class I transport by the molecular chaperone, calnexin (p88, IP90)
38. Calnexin retains unassembled major histocompatibility complex class I free heavy chains in the endoplasmic reticulum
39. Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP
40. Peptide-binding specificity of the molecular chaperone BiP
41. Protein maturation in the endoplasmic reticulum
42. Structure, function, and regulation of the endoplasmic reticulum chaperone, BiP
43. Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis
44. ATP is required for in vitro assembly of MHC class I antigens but not for transfer of peptides across the ER membrane
45. Monoclonal antibodies to the human multicatalytic proteinase (proteasome)
46. 2-microglobulin mRNA in human Daudi cells has a mutated initiation codon but is still inducible by interferon
47. Induction of HLA expression in Daudi cells after cell fusion
48. Rescue of Daudi cell HLA expression by transfection of the mouse beta 2-microglobulin gene
49. Biosynthesis of HLA-C heavy chains in melanoma cells with multiple defects in the expression of HLA-A, -B, -C molecules
50. Regulation of MHC class I heterodimer stability and interaction with TAP by tapasin
51. The amino acid sequence and gene organization of the heavy chain of the HLA-DR antigen: Homology to immunoglobulins
52. Folding of VSV G protein: Sequential interaction with BiP and calnexin
53. Calnexin and BiP act as sequential molecular chaperones during thyroglobulin folding in the endoplasmic reticulum
54. A recycling pathway between the endoplasmic reticulum and the Golgi apparatus for retention of unassembled MHC class I molecules
55. Hepatitis B surface antigen assembles in a post-ER, pre-Golgi compartment