Role of proteinase 3 in activation of endothelium

Springer Seminars in Immunopathology

Volumn 23, Issue 3, 2001, Pages 299-314

  Taekema Roelvink, M E J ^a   Van Kooten, C ^a   Verburgh, C A ^a   Daha, M R ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN G; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; LEUKOCYTE ELASTASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOBLASTIN; MYELOPEROXIDASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PADGEM PROTEIN; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

APOPTOSIS; CELL DAMAGE; CHURG STRAUSS SYNDROME; ENDOTHELIUM CELL; GLOMERULONEPHRITIS; HISTOPATHOLOGY; HUMAN; NECROTIZING ARTERITIS; PRIORITY JOURNAL; REVIEW; SYSTEMIC VASCULITIS; VASCULAR ENDOTHELIUM; VASCULITIS; WEGENER GRANULOMATOSIS;

CHURG-STRAUSS SYNDROME; ENDOTHELIUM, VASCULAR; MODELS, IMMUNOLOGICAL; MYELOBLASTIN; SERINE ENDOPEPTIDASES; VASCULITIS; WEGENER GRANULOMATOSIS;

EID: 0034864279     PISSN: 03444325     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002810100078     Document Type: Review

References (90)

1. Detachment and cytolysis of human endothelial cells by proteinase 3
2. Proteinase 3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro
3. The role of antineutrophil cytoplasm antibodies, anticardiolipin antibodies, von Willebrand factor antigen, and fibronectin for the diagnosis of systemic vasculitis
4. Clinical relevance of elevated serum thrombomodulin and soluble E-selectin in patients with Wegener's granulomatosis and other systemic vasculitides
5. IL-1β production by human polymorphonuclear leucocytes stimulated by anti-neutrophil cytoplasmic autoantibodies: Relevance to systemic vasculitis
6. IgG anti-endothelial cell autoantibodies from patients with systemic lupus erythematosus or systemic vasculitis stimulate the release of two endothelial cell-derived mediators, which enhance adhesion molecule expression and leukocyte adhesion in an autocrine manner
7. Clinical significance of anti-endothelial cell antibodies in systemic vasculitis: A longitudinal study comparing anti-endothelial cell antibodies and anti-neutrophil cytoplasm antibodies
8. Antibodies against granule proteins activate neutrophils in vitro
9. Interleukin-8: A pathogenetic role in antineutrophil cytoplasmic autoantibody-associated glomerulonephritis
10. In situ analysis of C-C chemokine mRNA in human glomerulonephritis
11. Converting enzyme-independent release of tumor necrosis factor-α and IL-1β from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3
12. Association between active Wegener's granulomatosis and anticytoplasmic antibodies
13. Dynamic pattern of endothelial cell adhesion molecule expression in muscle and perineural vessels from patients with classic polyarteritis nodosa
14. Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo
15. Proteolytically activated receptor-3. A member of an emerging gene family of protease receptors expressed on vascular endothelial cells and platelets
16. Idiopathic microscopic polyarteritis nodosa: Ultrastructural observations on the renal vascular and glomerular lesions
17. Lymphocyte activation markers and von Willebrand factor antigen in Wegener's granulomatosis: Potential markers for disease activity
18. Anti-proteinase-3 (PR3) antibodies (c-ANCA) recognize various targets on the human umbilical vein endothelial cell (HUVEC) membrane
19. Antibodies to proteinase-3 mediate expression of intercellular adhesion molecule-1 (ICAM-1, CD 54)
20. Induction of interleukin-1 and subsequent tissue factor expression by anti-proteinase 3 antibodies in human umbilical vein endothelial cells
21. Enhanced expression of the tumour necrosis factor/cachectin gene in peripheral blood mononuclear cells from patients with systemic vasculitis
22. Characterizatiorn of the endothelial surface proteins recognized by anti-endothelial antibodies in primary and secondary autoimmune vasculitis
23. Anti-endothelial cell IgG antibodies from patients with Wegener's granulomatosis bind to human endothelial cells in vitro and induce adhesion molecule expression and cytokine secretion
24. Antibodies to endothelial cells in primary vasculitides mediate in vitro endothelial cytotoxicity in the presence of normal peripheral blood mononuclear cells
25. Anti-neutrophil cytoplasmic antibodies and anti-endothelial cell antibodies
26. The endothelial cell protein C receptor
27. Anti-myeloperoxidase antibodies stimulate neutrophils to damage human endothelial cells
28. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro
29. Anti-endothelial cell antibodies in patients with Wegener's granulomatosis and micropolyarteritis
30. Autoantibodies to endothelial cells and neutrophil cytoplasmic antigens in systemic vasculitis
31. Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor
32. Anti-neutrophil cytoplasmic antibodies and disease activity during long-term follow-up of 70 patients with systemic vasculitis
33. The pathologic spectrum of pulmonary lesions in patients with anti-neutrophil cytoplasmic autoantibodies specific for anti-proteinase 3 and anti-myeloperoxidase
34. Wegener's granulomatosis. Pathology and review of the literature
35. Disease activity and autoantibodies to endothelial cells in patients with Wegener's granulomatosis
36. Serum cytokine changes in systemic vasculitis
37. Neutrophil-mediated endothelial injury in vitro. Mechanisms of cell detachment
38. Elevated levels of markers of endothelial cell damage and markers of activated coagulation in patients with systemic necrotizing vasculitis
39. Fibronectin controls capillary endothelial cell growth by modulating cell shape
40. Antineutrophil cytoplasmic autoantibody-associated diseases: A pathologist's perspective
41. The pathology of vasculitis involving the kidney
42. Nomenclature of systemic vasculitides: Proposal of an international consensus conference
43. Activation of normal neutrophils by anti-neutrophil cytoplasm antibodies
44. Endothelial cells and renal epithelial cells do not express the Wegener's autoantigen, proteinase 3
45. Antineutrophil cytoplasmic antibodies preferentially engage FcγRIIIb on human neutrophils
46. The soluble endothelial protein C receptor binds to activated neutrophils: Involvement of proteinase-3 and CD11b/CD18
47. E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro
48. Human endothelial cells express proteinase 3, the target antigen of anticytoplasmic antibodies in Wegener's granulomatosis
49. Antibodies to proteinase 3 increase adhesion of neutrophils to human endothelial cells
50. Anti-PR-3 antibodies induce endothelial IL-8 release
51. Cytotoxic effects of antibodies to proteinase 3 (c-ANCA) on human endothelial cells
52. Antibodies to proteinase 3 mediate expression of vascular cell adhesion molecule-1 (VCAM-1)
53. Proteolysis of the human platelet and endothelial cell thrombin receptor by neutrophil-derived cathepsin G
54. Circulating adhesion molecules ICAM-1 and VCAM-1 and E-selectin in systemic vasculitis: Marked differences between Wegener's granulomatosis and systemic lupus erythematosus
55. Leukocyte membrane expression of proteinase 3 correlates with disease activity in patients with Wegener's granulomatosis
56. Are circulating neutrophils intravascularly activated in patients with anti-neutrophil cytoplasmic (ANCA)-associated vasculitides?
57. Anticytoplasmic autoantibodies: Their immunodiagnostic value in Wegener granulomatosis
58. In situ production of TNF-α, IL-1β and IL-2R in ANCA-positive glomerulonephritis
59. The acute vasculitis of Wegener's granulomatosis in renal biopsies
60. Plasma thrombomodulin in Wegener's granulomatosis as an indicator of vascular injuries
61. Glomerular vascular cell adhesion molecule-1 expression in renal vasculitis
62. Adhesion molecules in human crescentic glomerulonephritis
63. ANCA antigens, proteinase 3 and myeloperoxidase, are not expressed in endothelial cells
64. Proteolytically inactive C-terminal death domain of proteinase 3
65. Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells
66. Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via FcγRIIa
67. Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells
68. Specific inhibition of thrombin-induced cell activation by the neutrophil proteinases elastase, cathepsin G and proteinase 3: Evidence for distinct cleavage sites within the amino-terminal domain of the thrombin receptor
69. Effect of tumor necrosis factor-induced integrin activation on Fcγ receptor II-mediated signal transduction: Relevance for activation of neutrophils by anti-proteinase 3 or anti-myeloperoxidase antibodies
70. Vascular damage in Wegener's granulomatosis and microscopic polyarteritis: Presence of anti-endothelial cell antibodies and their relation to anti-neutrophil cytoplasm antibodies
71. Myeloperoxidase binds to vascular endothelial cells, is recognized by ANCA and can enhance complement dependent cytotoxicity
72. Autoantibodies developing to myeloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity toward cultured endothelial cells
73. In situ expression and soluble form of P-selectin in human glomerulonephritis
74. Wegener's granulomatosis: Anti-proteinase 3 antibodies are potent inductors of human endothelial cell signaling and leakage response
75. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex
76. Serum levels of soluble adhesion molecules intercellular adhesion molecule 1, vascular cell adhesion molecule 1, and E-selectin in patients with Wegener's granulomatosis. Relationship to disease activity and relevance during followup
77. Proteinase 3 interacts with a 111-kD membrane molecule of human umbilical vein endothelial cells
78. Effect of anti-neutrophil cytoplasmic antibodies on proteinase 3-induced apoptosis of human endothelial cells
79. Renal biopsy findings in Wegener's granulomatosis: Segmental necrotizing glomerulonephritis with glomerular thrombosis
80. Elastase-mediated fibrinogenolysis by chemoattractant-stimulated neutrophils occurs in the presence of physiologic concentrations of antiproteinases
81. Neutrophil-mediated damage to human vascular endothelium. Role of cytokine activation
82. Epitopes on proteinase-3 recognized by antibodies from patients with Wegene's granulomatosis
83. A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis
84. Phagocytosing macrophages exclude proteins from the zones of contact with opsonized targets
85. Tumor necrosis factor decreases thrombin receptor expression in endothelial cells
86. Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase
87. Internalization of PR3 and MPO is concomitant with endothelial cell damage
88. Granulomatous glomerulonephritis in Wegener's granulomatosis
89. Pulmonary lesions in Wegener's granulomatosis: A clinicopathologic study of 22 autopsy cases
90. Signal transduction pathways modulated by proteinase 3 treatment