Structural biology and its applications to the health sciences

Croatian Medical Journal

Volumn 42, Issue 4, 2001, Pages 375-378

  Oakley, A J ^a   Ketterman, A ^a   Wilce, M C J ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Anopheles; Crystallography, X ray; Drug design; Glutathione transferase; Insect vectors; Magnetic resonance spectroscopy; Malaria

Indexed keywords

2 DEOXY 2,3 DIDEHYDRO DEXTRO N ACETYLNEURAMINIC ACID; GELDANAMYCIN; GENE PRODUCT; GLUTATHIONE TRANSFERASE; HEAT SHOCK PROTEIN 90; INDINAVIR; N ACETYLNEURAMINIC ACID DERIVATIVE; NELFINAVIR; PESTICIDE; PROTEINASE; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS SIALIDASE; ZANAMIVIR;

ANOPHELES; BIOLOGY; DRUG DESIGN; HEALTH SCIENCE; INSECTICIDE RESISTANCE; MALARIA; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARASITE VECTOR; PROTEIN STRUCTURE; REVIEW; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; ANOPHELES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; GENES; GLUTATHIONE TRANSFERASE; HUMANS; INSECT VECTORS; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION;

EID: 0034858452     PISSN: 03539504     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (22)

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2. A structure of deoxyribose nucleic acid
3. Gene mutation in human haemoglobin: The chemical difference between normal and sickle cell haemoglobin
4. Analysis of the intermolecular contacts within sickle hemoglobin fibers: Effect of site-specific substitutions, fiber pitch, and double-strand disorder
5. Macromolecular crystallography as a tool for investigating drug, enzyme and receptor interactions
6. Structure determination of biological macromolecules in solution using nuclear magnetic resonance spectroscopy
7. Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution
8. Rational design of potent sialidase-based inhibitors of influenza virus replication
9. Complete nucleotide sequence of the aids virus HTLV-III
10. Human immuno-deficiency virus has an aspartic-type protease that can be inhibited by pepstatin A
11. X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology amongst retroviral enzymes
12. Inhibitors of HIV-1 protease: A major success of structure assisted drug design
13. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
14. Crystal structure of an Hsp90- geldanamycin complex: Targeting of a protein chaperone by an antitumor agent
15. Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
16. The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance
17. Isoenzymes of glutathione S-transferase from the mosquito Anopheles dirus species B: The purification, partial characterization and interaction with various insecticides
18. Partial purification and characterization of glutathione S-transferases involved in DDT resistance from the mosquito Anopheles gambiae
19. DDT-resistance in Anopheles gambiae Giles from Zanzibar Tanzania based on increased DDT-dehydrochlorinase activity of glutathione S-transferases
20. Genomic organization and putative promoters of highly conserved glutathione S-transferases originating by alternative splicing in Anopheles dirus
21. Heterologous expression and characterization of alternatively spliced glutathione S-transferases from a single Anopheles gene
22. Crystal structure of a theta-class glutathione transferase