Tissue inhibitor of metalloproteinase-3 is a basement membrane-associated protein that is significantly decreased in human colorectal cancer

Diseases of the Colon and Rectum

Volumn 44, Issue 9, 2001, Pages 1290-1296

  Neumayer, Leigh ^a,b   Mastin, Mary ^a,b   Vanderhoof, Lana ^a,b   Hinson, Douglas ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Colorectal cancer; Matrix metalloproteinases; Tissue inhibitor of metalloproteinase

Indexed keywords

MEMBRANE PROTEIN; STROMELYSIN INHIBITOR;

ADENOMA; ADULT; ADVANCED CANCER; ANGIOGENESIS; ARTICLE; BASEMENT MEMBRANE; CANCER INVASION; CANCER STAGING; CARCINOGENIC ACTIVITY; CLINICAL ARTICLE; COLORECTAL CANCER; CORRELATION FUNCTION; HUMAN; HUMAN TISSUE; METASTASIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; BASEMENT MEMBRANE; BLOTTING, NORTHERN; BLOTTING, WESTERN; COLORECTAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; PROTEASE INHIBITORS; TISSUE INHIBITOR OF METALLOPROTEINASE-3;

EID: 0034854897     PISSN: 00123706     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02234786     Document Type: Article

References (41)

1. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
2. A matrix metalloproteinase expressed on the surface of invasive tumour cells
3. An inhibitor of collagenase from human amniotic fluid: Purification, characterization and action on metalloproteinases
4. Tissue inhibitor of metalloproteinase (TIMP-2): A new member of the metalloproteinase inhibitor family
5. A new inhibitor of metalloproteinases from chicken: ChIMP-3. A third member of the TIMP family
6. Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4
7. Molecular characterization and expression of the gene encoding human erythroid-potentiating activity
8. Inhibition of stimulated bone resorption in vitro by TIMP-1 and TIMP-2
9. Alpha 2-macroglobulin and tissue inhibitor of metalloproteinases: Collagenase inhibitors in human preovulatory ovaries
10. Mechanism of control of trophoblast invasion in situ
11. Elevated metalloproteinase and tissue inhibitor of metalloproteinase mRNA in human osteoarthritic synovia
12. Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells
13. Tumor cell invasion inhibited by TIMP-2
14. Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line
15. Inhibition of collagenolytic activity and metastasis of tumor cells by a recombinant human tissue inhibitor of metalloproteinases
16. Growth-promoting activity of tissue inhibitor of metalloproteinases-1 (TIMP-1) for a wide range of cells: A possible new growth factor in serum
17. Tissue inhibitor of metalloproteinase-2 (TIMP-2) has erythroid-potentiating activity
18. Proteinase expression in early mouse embryos is regulated by leukaemia inhibitory factor and epidermal growth factor
19. Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP-3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10
20. Human TIMP-3 is expressed during fetal development, hair growth cycle, and cancer progression
21. Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22
22. Structure of the human TIMP-3 gene and its cell cycle-regulated promoter
23. Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: One is homologous to human tissue inhibitor of metalloproteinases-3
24. Suppression of in vivo tumor growth and induction of suspension cell death by tissue inhibitor of metalloproteinases (TIMP)-3
25. A review of tissue inhibitor of metalloproteinases-3 (TIMP-3) and experimental analysis of its effect on primary tumor growth
26. Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family
27. The tissue inhibitor of metalloproteinases-3 gene in breast carcinoma: Identification of multiple polyadenylation sites and a stromal pattern of expression
28. TIMP-3 mRNA expression is regionally increased in moderately and poorly differentiated colorectal adenocarcinoma
29. Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells
30. The prognostic significance of direct extension of carcinoma of the colon and rectum
31. Molecular cloning of mouse tissue inhibitor of metalloproteinases-3 and its promoter: Specific lack of expression in neoplastic JB6 cells may reflect altered gene methylation
32. Distinct pattern of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 mRNA expression in human colorectal cancer and liver metastases
33. Colocalisation of matrix metalloproteinase-9-mRNA and protein in human colorectal cancer stromal cells
34. Molecular insights into cancer invasion: Strategies for prevention and intervention
35. Loss of basement membrane type IV collagen is associated with increased expression of metalloproteinases 2 and 9 (MMP-2 and MMP-9) during human colorectal tumorigenesis
36. Differential functional significance of AP-1 binding sites in the promoter of the gene encoding mouse tissue inhibitor of metalloproteinases-3
37. Post-transcriptional regulation of extracellular matrix metalloproteinase in human heart end-stage failure secondary to ischemic cardiomyopathy
38. Unique activation of matrix metalloproteinase-9 within human liver metastasis from colorectal cancer
39. Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3
40. Role of the 21-kDa protein TIMP-3 in oncogenic transformation of cultured chicken embryo fibroblasts
41. Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro: TIMP-3 promotes apoptosis