Deoxythioguanosine triphosphate impairs HIV replication: A new mechanism for an old drug

FASEB Journal

Volumn 15, Issue 11, 2001, Pages 1902-1908

  Krynetskaia, Natalia F ^a   Feng, Joy Y ^b   Krynetski, Eugene Y ^a   Garcia, J Victor ^c   Panetta, John C ^a   Anderson, Karen S ^b   Evans, William E ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Thioguanylated DNA; Thiopurines; Viral RNase H

Indexed keywords

ANTIRETROVIRUS AGENT; DEOXYTHIOGUANOSINE; DEOXYTHIOGUANOSINE TRIPHOSPHATE; DRUG METABOLITE; GUANOSINE DERIVATIVE; MERCAPTOPURINE; PROTEINASE; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE; TIOGUANINE; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS RNA; ZIDOVUDINE;

ARTICLE; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE CULTURE; PRIORITY JOURNAL; VIRUS REPLICATION;

6-MERCAPTOPURINE; ANTI-HIV AGENTS; BASE SEQUENCE; CELLS, CULTURED; DEOXYGUANINE NUCLEOTIDES; DNA; HELA CELLS; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID HETERODUPLEXES; NUCLEIC ACID SYNTHESIS INHIBITORS; POLYMERS; RIBONUCLEASE H, CALF THYMUS; RNA; THIOGUANINE; THIONUCLEOTIDES; VIRUS REPLICATION;

DNA VIRUSES; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0034848315     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.01-0124com     Document Type: Article

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