Synthesis, antiplatelet-activity, and cytotoxic evaluation of certain phenyldicoumarol derivatives

Chinese Pharmaceutical Journal

Volumn 53, Issue 2, 2001, Pages 85-95

  Chen, Y L ^a   Chen, I L ^a   Chung, C H ^a   Chen, P H ^a   Tzeng, C C ^a   Teng, C M ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

4 Hydroxycoumarin; Antiplatelet aggregation; Cytotoxicity; Renal cancer

Indexed keywords

AGGLOMERATION; CELLS; CONDENSATION; DERIVATIVES; EVALUATION;

CYTOTOXICITY;

SYNTHESIS (CHEMICAL);

3,3' (4 AMINOBENZYLIDENE) 4,4' EPOXYCOUMARIN; 3,3' (4 AMINOBENZYLIDENE) BIS 4 HYDROXYCOUMARIN; 3,3' (4 FLUOROBENZYLIDENE) BIS 4 HYDROXYCOUMARIN; 3,3' [4 (2 OXO 2 PHENYLETHOXY)BENZYLIDENE] BIS 4 HYDROXYCOUMARIN; 3,3' [4 (2 OXOPROPOXY)BENZYLIDENE] BIS 4 HYDROXYCOUMARIN; 4 HYDROXYCOUMARIN DERIVATIVE; BENZALDEHYDE; DICOUMAROL DERIVATIVE; PHENYLDICOUMAROL; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; POLYMERIZATION; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION;

EID: 0034845667     PISSN: 10161015     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Use of medium-sized cycloalkyl rings to enhance secondary binding: Discovery of a new class of human immunodeficiency virus (HIV) protease inhibitors
2. Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease
3. Coumarin-based inhibitors of HIV-1 integrase
4. Synthesis of coumarin derivatives as inhibitors of platelet aggregation
5. Synthesis and evaluation of coumarin α-methylene-γ-butyrolactones: A new class of platelet aggregation inhibitors
6. α-methylene-γ-butyrolactones: Synthesis and vasorelaxing activity assay of coumarin, naphthalene, and quinoline derivatives
7. Synthesis and cytotoxicity evaluation of certain α-methylidene-γ-butyrolactones bearing coumarin, flavone, xanthone, carbazole, and dibenzofuran moieties
8. Synthesis, toxicological, and pharmacological assessment of some oximes and aldehyde condensation products of 4-hydroxycoumarin
9. Comparison of the platelet aggregation induced by three thrombin-like enzymes of snake venoms and thrombin
10. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
11. Platelet aggregation II, some results from a new method of study