Novel aryl substituted bicyclic furo nucleosides as extremely potent and selective anti-VZV agents

Nucleosides, Nucleotides and Nucleic Acids

Volumn 20, Issue 4-7, 2001, Pages 287-296

  McGuigan, C ^a   Barucki, H ^a   Carangio, A ^a   Blewett, S ^a   Srinivasan, S ^a   Andrei, G ^a   Snoeck, R ^a   De Clercq, E ^a   Balzarini, J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2' DEOXY BETA DEXTRO RIBOFURANOSYL) 6 (4 N BUTYLPHENYL) 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2 ONE; 3 (2' DEOXY BETA DEXTRO RIBOFURANOSYL) 6 (4 N ETHYLPHENYL) 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2 ONE; 3 (2' DEOXY BETA DEXTRO RIBOFURANOSYL) 6 (4 N METHYLPHENYL) 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2 ONE; 3 (2' DEOXY BETA DEXTRO RIBOFURANOSYL) 6 (4 N PENTYLPHENYL) 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2 ONE; 3 (2' DEOXY BETA DEXTRO RIBOFURANOSYL) 6 (4 N PROPYLPHENYL) 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2 ONE; DEOXYURIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; CONFERENCE PAPER; DRUG STRUCTURE; DRUG SYNTHESIS; LIPOPHILICITY; VARICELLA ZOSTER VIRUS;

ANTIVIRAL AGENTS; ARABINONUCLEOSIDES; BICYCLO COMPOUNDS, HETEROCYCLIC; CELLS, CULTURED; FIBROBLASTS; HERPESVIRUS 3, HUMAN; HUMANS; PYRIMIDINE NUCLEOSIDES;

HUMAN HERPESVIRUS 3;

EID: 0034844894     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-100002299     Document Type: Conference Paper

References (19)

1. Design, synthesis and biological evaluation of novel nucleotide prodrugs as inhibitors of HIV replication
2. Mechanism of anti-HIV action of masked alaninyl d4TMP derivatives
3. Conversion of 2′,3′-dideoxyadenosine (ddA) and 2′,3′-didehydro-2′,3′-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus
4. Certain phosphoramidate derivatives of dideoxy uridine [ddU] are active against HIV and successfully by-pass thymidine kinase
5. Synthesis and evaluation of 5-halo 2′,3′-didehydro-2′,3′-dideoxy nucleosides and their blocked phosphoramidates as potential anti-HIV agents: An example of kinase bypass
6. Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base
7. Nucleic-acid related-compounds .39. Efficient conversion of 5-iodo to 5-alkynyl and derived 5-substituted uracil bases and nucleosides
8. Nucleic-acid related-compounds .31. Smooth and efficient palladium copper catalyzed coupling of terminal alkynes with 5-iodouracil nucleosides
9. Palladium-catalyzed coupling of terminal alkynes with 5-(trifluoromethanesulfonyloxy)pyrimidine nucleosides
10. Synthesis and biological evaluation of 5-(1-alkoxy-2-haloethyl)-2′-deoxyuridines and related uracil analogs
11. Steric fixation of bromovinyluracil-synthesis of furo [2,3-D]pyrimidine nucleosides
12. Synthesis of 5-(1-azidovinyl) and 5-[2-(1-azirinyl)] analogs of 2′-deoxyuridine
13. Synthesis of dodecadeoxyribonucleotides containing a pyrrolo[2,3-D]pyrimidine nucleoside and their base-pairing ability
14. Oxidative addition of unsaturated acid-esters to 1,3-dimethyluracil and pyrimidine nucleosides
15. Bicyclic nucleoside inhibitors of varicella-zoster virus (VZV): The effect of a terminal halogen substitution in the side chain
16. Exquisitely potent and selective inhibition of varicella-zoster virus (VZV) by bicyclic furo pyrimidine nucleosides bearing an aryl side-chain
17. Comparative efficacy of antiherpes drugs against various strains of varicella-zoster virus
18. Novel mouse models for the investigation of experimental drugs with activity against human varicella-zoster virus