Synthesis and evaluation of 5-halo 2',3'-didehydro-2',3'- dideoxynucleosides and their blocked phosphoramidates as potential anti-human immunodeficiency virus agents: An example of 'kinase bypass'

Antiviral Chemistry and Chemotherapy

Volumn 8, Issue 6, 1997, Pages 519-527

  McGuigan, C ^a   Velazquez S ^a,b   De Clercq, E ^c   Balzarini, J ^c  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

d4T nucleoside analogues; HIV nucleoside analogues; Phosphoramidates; Stereoselective glycosidation kinase bypass

Indexed keywords

2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; ANTIVIRUS AGENT; NUCLEOSIDE ANALOG; PHOSPHORAMIDIC ACID DERIVATIVE; PHOSPHOTRANSFERASE; STAVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL;

EID: 1842367969     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632029700800605     Document Type: Article

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