Structures of an unliganded neurophysin and its vasopressin complex: Implications for binding and allosteric mechanisms

Protein Science

Volumn 10, Issue 9, 2001, Pages 1869-1880

  Wu, Chia Kuei ^a   Hu, Bing ^a   Rose, John P ^a   Liu, Zhi Jie ^a   Nguyen, Tam L ^b   Zheng, Changsheng ^b,c   Breslow, Esther ^b   Wang, Bi Cheng ^a  

^a University of Georgia ^*  (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c DUPONT COMPANY   (United States)

Author keywords

Crystal structures; Neurophysin; Unliganded state; Vasopressin complex

Indexed keywords

ALPHA AMINO ACID; NEUROPHYSIN; OXYTOCIN; VASOPRESSIN;

ALLOSTERISM; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; HYDROGEN BOND; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; THERMODYNAMICS;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; CATTLE; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; LIGANDS; LYSINE VASOPRESSIN; MODELS, MOLECULAR; NEUROPHYSINS; OXYTOCIN; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; VASOPRESSINS;

BOVINAE;

EID: 0034842483     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.10601     Document Type: Article

References (40)

1. Evaluation of direct and cooperative contributions towards the strength of buried hydrogen bonds and salt bridges
2. The protein data bank: A computer-based archival file for macromolecular structures
3. 13C in the glycinamide-9 and half-cystine-1 positions
4. Molecular, thermodynamic and biological aspects of recognition and function in neurophysin-hormone systems: A model system for the analysis of protein-peptide interactions
5. Binding properties of bovine neurophysins I and II: An equilibrium dialysis study
6. Physical and chemical properties of the bovine neurophysins
7. Small peptides as analogs of oxytocin and vasopressin in their interactions with bovine neurophysin-II
8. Binding and fluorescence studies of the relationship between neurophysin-peptide interaction and neurophysin self-association: An allosteric system exhibiting minimal cooperativity
9. NMR behavior of the aromatic protons of bovine neurophysin-I and its peptide complexes: Implications for solution structure and for function
10. Structural basis of neurophysin hormone specificity: Geometry, polarity and polarizability in aromatic ring interactions
11. Free R value-A novel statistical quantity for assessing the accuracy of crystal structures
12. Crystallographic refinement by simulated annealing-Application to crambin
13. Complete assignment of neurophysin disulfides indicates pairing in two separate domains
14. Identification of human neurophysins: Complete amino acid sequences of MSEL- and VLDV-neurophysins
15. Crystal structure of a bovine neurophysin II dipeptide complex at 2.8 Å determined from the single-wavelength anomalous scattering signal of an incorporated iodine atom
16. Accurate bond and angle parameters for X-ray protein structure refinement
17. The Midas display system
18. Do salt bridges stabilize proteins? A continuum electrostatic analysis
19. Cryocrystallography of biological molecules: A generally applicable method
20. The use of an imaging proportional counter in macromolecular crystallography
21. High resolution crystals of bovine neurophysin II complexed with vasopressin
22. Improved methods for binding protein models in electron density maps and the location of errors in these models
23. Molecular properties of the oxytocin/bovine neurophysin biosynthetic precursor
24. Structure of pressinoic acid: The cyclic moiety of vasopressin
25. Procheck-A program to check the stereochemical quality of protein structures
26. Traitment statistique des erreurs dans la determinations des structures cristallines
27. AMoRe: An automated package for molecular replacement
28. Importance of neurophysin dimer and of tyrosine-49 in the binding of neurohypophyseal peptides
29. Bovine neurophysin dimerization and neurohypophyseal hormone binding
30. Processing of X-ray diffraction data collected in oscillation mode
31. Interaction of bovine neurophysin with oxytocin and vasopressin measured by temperature-jump relaxation
32. Binding of neurophypophyseal peptides to neurophysin dimer promotes formation of compact and spherical complexes
33. Crystal structure of the neurophysin-oxytocin complex
34. Detection of sub-units within crystallographic asymmetric unit
35. Mounting of crystals for macromolecular crystallography in a freestanding thin film
36. i1-H'''O = C hydrogen bond?
37. Crystals of ligand-free bovine neurophysin II
38. Protein binding versus protein folding: The role of hydrophilic bridges in protein associations
39. The behavior of the active site salt bridge of bovine neurophysins as monitored by 15N NMR spectroscopy and chemical substitution. Relationship to biochemical properties
40. Modulation of dimerization by residues distant from the interface in bovine neurophysin-II