Comment: The long, hard road: Drug metabolism in the lifetime of the DMDG

Xenobiotica

Volumn 31, Issue 8-9, 2001, Pages 459-467

  Smith, D A ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIARRHYTHMIC AGENT; ANTIHISTAMINIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CISAPRIDE; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; GLYCOPROTEIN P; HALOPERIDOL; PRODRUG; QUINIDINE; TERFENADINE; VERAPAMIL; DRUG;

CARDIOTOXICITY; DRUG ABSORPTION; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG INDUSTRY; DRUG METABOLISM; DRUG RESEARCH; DRUG TRANSPORT; HUMAN; LIPOPHILICITY; NOTE; ORGANIZATION; PHARMACODYNAMICS; STRUCTURE ACTIVITY RELATION; TECHNOLOGY; ANIMAL; ARTICLE; BIOTECHNOLOGY; DRUG EFFECT; DRUG INTERACTION; EUROPE; HEALTH CARE ORGANIZATION; HEART; METABOLISM; PHARMACOKINETICS;

ANIMALS; BIOTECHNOLOGY; DRUG DESIGN; DRUG INDUSTRY; DRUG INTERACTIONS; EUROPE; HEART; HUMANS; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; SOCIETIES, SCIENTIFIC;

EID: 0034836980     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/00498250110052742     Document Type: Note

References (16)

1. Comment: Twenty years on: A review of the current practice of drug metabolism and pharmacokinetic studies in the pharmaceutical industry
2. In vivo pharmacokinetic screening in cassette dosing experiments, the use of on-line prospekt liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry technology in drug discovery
3. Pharmacokinetics of verapimil and its metabolites in elderly and young volunteers
4. The state of the art: A commentary on the current practice of metabolism and pharmacokinetic studies in the pharmaceutical industry
5. Reduced dimension HPLC columns as a preclinical tool for rapid separations in drug discovery
6. Success rates for new drugs entering clinical testing in the United States
7. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
8. Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985)
9. HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine
10. Pharmacokinetics and metabolism in early drug discovery
11. + channels expressed in Zenous
12. Structure-toxicity relationship of acrylates and methacrylates
13. A proposed approach to study the toxicology of complex mixtures of petroleum products: The integrated use of QSAR, lumping analysis and PBPK/PD modeling
14. Effects of inhaled acrylic acid derivates in rats
15. Approaches to developing alternative and predictive toxicology based on PBPK/PD and QSAR modeling