Effect of verapamil enantiomers and metabolites on cardiac K + channels expressed in Xenopus oocytes

Cellular Physiology and Biochemistry

Volumn 9, Issue 2, 1999, Pages 81-89

  Waldegger, S ^a   Niemeyer, G ^a   Morike K ^a   Wagner, C A ^a   Suessbrich, H ^a   Busch, A E ^a   Lang, F ^a   Eichelbaum, M ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

Author keywords

Calcium blockers; Cardiac arrhythmias; Cardiac repolarization; HERG; IsK; KvLQT1; Long Q T syndrome

Indexed keywords

5 [N [2 (3,4 DIMETHOXYPHENYL)ETHYL] N METHYLAMINO] 2 (4 HYDROXY 3 METHOXYPHENYL) 2 ISOPROPYLVALERONITRILE; DEALKYLNORVERAPAMIL; DEALKYLVERAPAMIL; NORVERAPAMIL; POTASSIUM CHANNEL; UNCLASSIFIED DRUG; VERAPAMIL; VERAPAMIL DERIVATIVE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENANTIOMER; HEART MUSCLE POTENTIAL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; VOLTAGE CLAMP; XENOPUS;

ANIMALIA;

EID: 0032773157     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000016304     Document Type: Article

References (36)

1. Endicott JA, Ling V: The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu Rev Biochem 1989;58:137-171.
2. Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y: Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res 1981; 41:1967-1972.
3. Pastan I, Gottesman MM: Multiple drug resistance in cancer. N Engl J Med 1987;316:1388-1393.
4. Benson AB III, Trump DL, Koeller JM, Egorin MI, Olman EA, Witte RS, Davis TE, Tormey DC: Phase I study of vinblastine and verapamil given by concurrent i.v. infusion. Cancer Treat Rep 1985;69:795-799.
5. Curtis MJ, Walkerm MJA: The mechanism of action of the optical enantiomers of verapamil against ischaemia-induced arrhythmias in the conscious rat. Br J Pharmacol 1986;89:137-147.
6. Echizen H, Manz M, Eichelbaum M: Electrophysiologic effects of dextro- and levoverapamil on sinus node and AV node function in humans. J Cardiovasc Pharmacol 1988;12:543-546.
7. Haeussermann K, Benz B, Gekeler V, Schumacher K, Eichelbaum M: Effects of verapamil enantiomers and major metabolites on the cytotoxicity of vincristine and daunomycin in human lymphoma cell lines. Eur J Clin Pharmacol 1991;40:53-59.
8. Schumacher K, Ladda E, Bühl K, Weimer A, Eser C, Traugott U, Roller E, Löffler B, Eichelbaum M: Reversal of multidrug resistance by R-verapamil; in Eichelbaum M, Hirth H-P, Schumacher K, Traugott U (eds): Dexverapamil - Circumventor of Multidrug Resistance. Dordrecht, Kluwer, 1993, pp 57-64.
9. Paulmichl M, Nasmith P, Hellmiss R, Boyle A, Nerbonne JM, Peralata EG, Clapham DE: Cloning and expression of a rat delayed rectifier potassium channel. Proc Natl Acad Sci USA 1991;88:7892-7895.
10. + channels; in Zipes D, Jalife J (eds): Cardiac Electrophysiology: From Cell to Bedside. Philadelphia, Saunders, 1994, pp 21-31.
11. Kr potassium channel. Cell 1995;81:299-307.
12. Curran ME, Splawski I, Timothy KW, Vincent GM, Gree ED, Keating M: A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 1995;80: 795-803.
13. chS in guinea pig cardiac myocytes. Biochem Biophys Res Commun 1994;202:265-270.
14. Wang Z, Fermini B, Nattel S: Rapid and slow components of delayed rectifier current in human and atrial myocytes. Cardiovasc Res 1994;28: 1540-1546.
15. KS potassium channel. Nature 1996;384:80-83.
16. Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, van Raay TJ, Shen J, Timothy KW, Vincent GM, de Jager T, Schwartz PJ, Towbin JA, Moss AJ, Atkinson DL, Landes GM, Connors TD, Keating MT: Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 1996;12:17-23.
17. + current in human ventricular myocytes. Circ Res 1996;78:689-696.
18. + current. J Gen Physiol 1990;96:195-215.
19. + channels in Xenopus oocytes. J Physiol 1996;491:735-741.
20. Warmke JW, Ganetzky B: A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci USA 1994;91: 3438-3442.
21. Murai T, Kakizuka A, Takumi T, Ohkubo H, Nakanishi S: Molecular cloning and sequence analysis of human genomic DNA encoding a novel membrane protein which exhibits a slowly activating potassium channel activity. Biochem Biophys Res Commun 1989;161:176-181.
22. Stuehmer W, Stocker M, Sakmann B, Seeburg P, Baumann A, Grupe A, Pongs O: Potassium channels expressed from rat brain cDNA have delayed rectifier properties. FEBS Lett 1988;242:199-206.
23. Kamb A, Weir M, Rudy B, Vermus H, Kenyon C: Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification. Proc Natl Acad Sci USA 1989;86: 4372-4376.
24. + channels are independently regulated by protein kinases and ATP-hydrolysis. Neuron 1994;13:1413-1420.
25. Kr channel. J Gen Physiol 1996; 107:611-619.
26. Suessbrich H, Waldegger S, Lang F, Busch AE: Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole. FEBS Lett 1996;385:77-80.
27. Suessbrich H, Schoenherr R, Heinemann SH, Attali B, Lang F, Busch AE: The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes. Br J Pharmacol 1997;120:968-974.
28. + channel cloned from human heart. Mol Pharmacol 1993;44:642-648.
29. + channels Kv1.2 and Kv1.4. Eur J Pharmacol 1995;281:151-159.
30. KS cardiac potassium current. Nature 1996;384: 78-80.
31. Amos GJ, Wettwer E, Li Q, Himmel HM, Ravens U: Differences in outward currents of human atrial and ventricular myocytes. Circulation 1994;4(suppl 1):1-581.
32. + channels involved in long QT syndromes, are targets for calcium channel blockers. Mol Pharmacol 1998;54:695-703.
33. 14 C]verapamil in man. Drug Metab Dispos 1979;7: 145-148.
34. Bril A, Gout B, Bonhomme M, Landais L, Faivre JF, Linee P, Poyser RH, Ruffolo RR Jr: Combined potassium and calcium channel blocking activities as a basis for antiarrhythmic efficacy with low proarrhythmic risk: Experimental profile of BRL-32872. J Pharmacol Exp Ther 1996;276:637-646.
35. Hollifield JW, Heusner JJ, DesChamps M, Gray J, Spyker DA, Peace KE, Dickson B: Comparison of equal-weight oral dosages of verapamil hydrochloride and diltiazem hydrochloride in patients with mild to moderate hypertension. Clin Pharmacol 1988;7:129-134.
36. Theisen K, Scheininger M: Electrophysiological effects of quinidine alone and of the combination quinidine-verapamil on AV conduction in humans. Clin Cardiol 1983;6: 405-411.